Analysis of the periodontal microbiota in childhood-type hypophosphatasia

Valenza, Giuseppe; Burgemeister, Stefan; Girschick, Hermann; Schoen, Christoph; Veihelmann, Simone; Moter, Annette; Haban, Vesna; Vogel, Ulrich; Schlagenhauf, Ulrich

doi:10.1016/j.ijmm.2006.05.002

Cited by 11 publications

(10 citation statements)

References 39 publications

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“…sequences with at least 99% identity, per clone library and patient (Table 2). In agreement with our previous findings (Hutter et al, 2003;Valenza et al, 2006), clone library 27f/519r harbored many sequences belonging to the phyla Fusobacteria and Bacteroidetes/Chlorobi, whereas 66% of all sequences of library 515f/1525r were assigned to the group of Firmicutes (Table 3). Therefore, the use of 2 different clone libraries resulted in improvement of the representation of the real distribution of phylotypes in comparison to the use of each primer pair alone.…”

Section: Changes Of the Subgingival Microbiota Following Periodontal supporting

confidence: 92%

Microbial changes in periodontitis successfully treated by mechanical plaque removal and systemic amoxicillin and metronidazole

Valenza

Veihelmann

Peplies

et al. 2009

International Journal of Medical Microbiology

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Section: Changes Of the Subgingival Microbiota Following Periodontal supporting

confidence: 92%

Microbial changes in periodontitis successfully treated by mechanical plaque removal and systemic amoxicillin and metronidazole

Valenza

Veihelmann

Peplies

et al. 2009

International Journal of Medical Microbiology

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“…According to the literature, loss of attachment affects up to 19% of the adult population between 35 and 64 years, 2.6% of males and 1.5% of females between 35 and 45 years (Bouchard et al, 2006) and periodontitis is the most frequent cause of tooth extraction for people over 40 years of age (Reich & Hiller, 1993). In addition the association between HP and periodontitis is documented (Baab et al, 1986; Watanabe et al, 1993; Plagmann et al, 1994; Watanabe et al, 1999) although still controversial (Machtei et al, 1994; Valenza et al, 2006; Reibel et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

A Molecular‐Based Estimation of the Prevalence of Hypophosphatasia in the European Population

Mornet

Yvard

Taillandier

et al. 2011

Annals of Human Genetics

193

150

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SummaryThe prevalence of hypophosphatasia (HP), a rare metabolic disorder due to loss-of-function mutations in the ALPL gene, has never been estimated in the European population. Only one published study evaluated the incidence of severe HP at 1/100,000 in Canada 53 years ago. Moderate forms of hypophosphatasia (mHP), including HP with moderate bone features and the mildest form odontohypophosphatasia, reflect both recessive and dominant inheritance, and are therefore expected to be more frequent than severe forms of HP. Here we estimated both the prevalences of severe and mHP in European populations. The prevalence of severe HP was estimated at 1/300,000 on the basis of the number of cases tested in our laboratory and originating from France during the period 2000-2009. The prevalence of mHP was then estimated by using the proportion of dominant mutations among severe alleles and by estimating the penetrance of the disease in heterozygotes for dominant mutations. According to a genetic model with four alleles resulting in 10 distinct genotypes, the prevalence of dominant mHP in the European population was estimated to be 1/6370, pointing out that mHP is much more frequent than severe HP.

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“…described an association between HP and periodontitis [ 16 , 20 , 21 ], while Valenza et al . found no signicative differences in subgingival microbiota of healthy patients and patients suffering from HP [ 22 ]. Baab et al .…”

Section: Discussionmentioning

confidence: 99%

“…Attachment loss in HP may be the result of a cemental or alveolar bone defects rather than the outcome of inflammation induced by bacterial growth. Longitudinal studies will be of interest to follow changes of the microbiota over time [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Orodental phenotype and genotype findings in all subtypes of hypophosphatasia

Reibel

Manière

Clauss

et al. 2009

Orphanet J Rare Dis

104

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This work allowed us to compare orodental manifestations in all the clinical forms of HP within the patient's sample. According to the severity of the disorder, some dental defects were infrequent, while other were always present. The long term prognosis of the permanent teeth varies from a patient to another. As premature loss of primary teeth is often the first, and sometimes the only visible symptom of the milder forms, the paediatric dentist plays a critical role in the detection and diagnosis of the disease.

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Analysis of the periodontal microbiota in childhood-type hypophosphatasia

Cited by 11 publications

References 39 publications

Microbial changes in periodontitis successfully treated by mechanical plaque removal and systemic amoxicillin and metronidazole

Microbial changes in periodontitis successfully treated by mechanical plaque removal and systemic amoxicillin and metronidazole

A Molecular‐Based Estimation of the Prevalence of Hypophosphatasia in the European Population

Orodental phenotype and genotype findings in all subtypes of hypophosphatasia

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