Analysis of the population heterogeneity in Hungary using fifteen forensically informative STR markers

Egyed, Balázs; Füredi, S.; Angyal, M.; Balogh, István; Kalmár, Lajos; Pádár, Zsolt

doi:10.1016/j.forsciint.2005.07.004

Cited by 21 publications

(8 citation statements)

References 17 publications

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“…The same level of genetic divergence was observed between different breeds (German shepherd, beagle and greyhound) in a South Korean population (80). Compared to these, the overall F ST and R ST values in our beagle population were below 1% (0.001 and 0.008, respectively), which are also much lower than observed in human populations (81). The weak signal of population structure was confirmed by the Structure analysis.…”

Section: Discussionsupporting

confidence: 78%

Comparison of Behavior and Genetic Structure in Populations of Family and Kenneled Beagles

et al. 2020

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In dogs, the social and spatial restriction associated with living in a kennel environment could lead to chronic stress and the development of abnormal behaviors ("kennel-dog syndrome"). However, little is known about how kenneled dogs differ from their conspecifics living as pets in human families. In the current study, using a test battery exposing the dogs to novel stimuli, we compared the behavior of three groups of beagles: (1) kenneled dogs living in a restricted environment with limited human contact (N = 78), (2) family dogs living in human families as pets (N = 37), and (3) adopted dogs born in the kenneled population but raised in human families (N = 13). We found one factor comprising most of the test behaviors, labeled as Responsiveness. Family dogs and adopted dogs scored higher in Responsiveness than kenneled dogs. However, 23% of the kenneled dogs were comparable to family and adopted dogs based on a cluster analysis, indicating a similar (positive) reaction to novel stimuli, while 77% of the kenneled dogs were unresponsive (mostly immobile) in at least part of the test. To assess if the behavioral difference between the family and kenneled dogs could be due to genetic divergence of these two populations and/or to lower genetic diversity of the kenneled dogs, we analyzed their genetic structure using 11 microsatellite markers. We found no significant difference between the populations in their genetic diversity (i.e., heterozygosity, level of inbreeding), nor any evidence that the family and kenneled populations originated from different genetic pools. Thus, the behavior difference between the groups more likely reflects a G × E interaction, that is, the influence of specific genetic variants manifesting under specific environmental conditions (kennel life). Nevertheless, some kenneled individuals were (genetically) more resistant to social and environmental deprivation. Selecting for such animals could strongly improve the welfare of kenneled dog populations. Moreover, exploring the genetic background of their higher resilience could also help to better understand the genetics behind stress-and fear-related behaviors.

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Section: Discussionsupporting

confidence: 78%

Comparison of Behavior and Genetic Structure in Populations of Family and Kenneled Beagles

et al. 2020

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“…Our recent data show less substructuring effects than the experienced values in Hungary [1,2,11]. The observed genetic discrepancies between the population pairs are in good accordance with the G-statistic findings where the same autosomal loci showed significant differences in the allele frequency distribution.…”

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confidence: 88%

Population genetic study in two Transylvanian populations using forensically informative autosomal and Y-chromosomal STR markers

Egyed

Füredi

Pádár

2006

Forensic Science International

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“…The individual samples in this study were essentially the same as those in a report on nuclear short tandem repeats (STR) [10], with a few individuals more (Roma) or less (Budapest). Additional STR loci from a subset of the samples in this paper were published in Füredi et al [11] and Egyed et al [12].…”

Section: Dna Samples and Extractionmentioning

confidence: 99%

Hungarian mtDNA population databases from Budapest and the Baranya county Roma

et al. 2006

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To facilitate forensic mtDNA testing in Hungary, we have generated control region databases for two Hungarian populations: 211 individuals were sampled from the urban Budapest population and 208 individuals were sampled from a Romani ("gypsy") population in Baranya county. Sequences were generated using a highly redundant approach to minimize potential database errors. The Budapest population had high sequence diversity with 180 lineages, 183 polymorphic positions, and a random match probability of 1%. In contrast, the Romani population exhibited low sequence diversity, with only 56 lineages, 109 segregating sites, and a random match probability of 8.8%. The mtDNA haplogroup compositions of the two populations were also distinct, with the large proportion of haplogroup M samples (35%) in the Roma the most obvious difference between the two populations. These factors highlight the importance of considering population structure when generating reference databases for forensic testing purposes. Comparisons between our Romani population sample and other published data indicate the need for heightened caution when sampling and using mtDNA databases of small endogamous populations. The Romani populations that we compared showed significant departures from genetic uniformity.

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Analysis of the population heterogeneity in Hungary using fifteen forensically informative STR markers

Cited by 21 publications

References 17 publications

Comparison of Behavior and Genetic Structure in Populations of Family and Kenneled Beagles

Comparison of Behavior and Genetic Structure in Populations of Family and Kenneled Beagles

Population genetic study in two Transylvanian populations using forensically informative autosomal and Y-chromosomal STR markers

Hungarian mtDNA population databases from Budapest and the Baranya county Roma

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