Analysis of the relationship between MIR155HG variants and gastric Cancer susceptibility

Zou, Wenjing; Xu, Li; Li, Cheng; Liú, Dan; Lv, Yunyun; Ying, Yang; Ye, Nan; Guo, Dan; He, Shuixiang

doi:10.1186/s12876-020-1169-8

Cited by 11 publications

(8 citation statements)

References 32 publications

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“…MIR155HG is transcribed from a gene located on chromosome 21q21 and consists of three exons that span 1.5 Kb in length. 31,32 In this study, lentivirus transfection was used to obtain MSCs with sustained high MIR155HG expression. MIR155HG significantly 19 Some lncRNAs regulate the cell viability through increasing the transcription of pro-inflammatory cytokines by enhancing inflammatory signals, such as NF-κB signalling.…”

Section: Discussionmentioning

confidence: 99%

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Improved therapeutic effects on vascular intimal hyperplasia by mesenchymal stem cells expressing MIR155HG that function as a ceRNA for microRNA‐205

Bai,

Qi,

Cai

et al. 2024

J Cellular Molecular Medi

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Coronary artery bypass grafting (CABG) is an effective treatment for coronary heart disease, with vascular transplantation as the key procedure. Intimal hyperplasia (IH) gradually leads to vascular stenosis, seriously affecting the curative effect of CABG. Mesenchymal stem cells (MSCs) were used to alleviate IH, but the effect was not satisfactory. This work aimed to investigate whether lncRNA MIR155HG could improve the efficacy of MSCs in the treatment of IH and to elucidate the role of the competing endogenous RNA (ceRNA). The effect of MIR155HG on MSCs function was investigated, while the proteins involved were assessed. IH was detected by HE and Van Gieson staining. miRNAs as the target of lncRNA were selected by bioinformatics analysis. qRT‐PCR and dual‐luciferase reporter assay were performed to verify the binding sites of lncRNA‐miRNA. The apoptosis, Elisa and tube formation assay revealed the effect of ceRNA on the endothelial protection of MIR155HG‐MSCs. We observed that MIR155HG improved the effect of MSCs on IH by promoting viability and migration. MIR155HG worked as a sponge for miR‐205. MIR155HG/miR‐205 significantly improved the function of MSCs, avoiding apoptosis and inducing angiogenesis. The improved therapeutic effects of MSCs on IH might be due to the ceRNA role of MIR155HG/miR‐205.

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Section: Discussionmentioning

confidence: 99%

“…At present, most studies on MIR155HG involve tumour or immunity, but few of them involve vascular remodelling. MIR155HG is transcribed from a gene located on chromosome 21q21 and consists of three exons that span 1.5 Kb in length 31,32 …”

Section: Discussionmentioning

confidence: 99%

Improved therapeutic effects on vascular intimal hyperplasia by mesenchymal stem cells expressing MIR155HG that function as a ceRNA for microRNA‐205

Bai,

Qi,

Cai

et al. 2024

J Cellular Molecular Medi

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“…In one report about colorectal cancer, Wu et al [31] reported that MIR155HG (rs12482371 and rs1893650) increased CRC risk, whereas rs928883 was associated with a reduced CRC risk. Zou et al [32] also showed MIR155HG (rs4143370, rs1893650, and rs11911469) were linked to the risk of gastric cancer susceptibility in the Chinese population. However, the study of this lncRNA in ESCC has not been reported.…”

Section: Discussionmentioning

confidence: 99%

The Single Nucleotide Polymorphisms rs4143370 and rs34904192 in MIR155HG Were Associated with Esophageal Cancer Risk in the Chinese Han Population

Jia¹,

Zhou²,

Ji³

et al. 2023

Digestion

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Introduction: MIR155HG has been found to play an important role in malignant tumors, but little research has been done on its association with esophageal cancer (ESCC). The aim of this study was to investigate the relationship between MIR155HG polymorphisms and ESCC susceptibility in the Chinese Han population. Methods: 511 ESCC patients and 487 healthy controls were selected for this study. All subjects were genotyped using the Agena MassARRAY platform. We assessed the association between seven single nucleotide polymorphisms (SNPs) of the MIR155HG and ESCC risk by genetic model analysis. The false discovery rate (FDR) test and Bonferroni correction were usually used to detect false positives for the results. Meanwhile, the interaction between SNPs was analyzed by multifactor dimensionality reduction software to predict the ESCC risk. Results: The C allele of rs4143370 and the A allele of rs34904192 in MIR155HG can increase the risk of ESCC (odds ratio (OR) = 1.33, p = 0.024; OR = 1.30, p = 0.013). Furthermore, rs4143370 and rs34904192 were associated with an increased risk of ESCC. Stratified analysis showed that MIR155HG SNPs (rs4143370 and rs34904192) significantly increased ESCC risk in males. MIR155HG SNPs (rs4143370, rs34904192, and rs928883) were also strongly associated with an increased risk of ESCC in people aged >64 years. In addition, haplotype analysis of the seven SNPs of the MIR155HG showed that the CC haplotype was associated with ESCC risk (OR = 1.34, p = 0.024). Conclusion: This study revealed that MIR155HG SNPs were associated with an increased risk of ESCC. The results provided clues for clarifying the role of MIR155HG in ESCC.

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“…MicroRNAs (miRNAs) are small, single-stranded, endogenous noncoding RNAs with a length of 21–25 nucleotides. They play biological roles by inhibiting the expression of target proteins at the posttranscriptional level [ 1 , 29 , 38 ]. According to the conformation analysis, more than one third of human genes are regulated by miRNAs, which indicates that miRNAs play an important role in regulating gene expression [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…MiR-17 and miR-155 are transcripts of MIR17HG and MIR155HG , respectively. MiR-17 and miR-155 are both multifunctional miRNAs, that play a consequential role in the occurrence, development, and prognosis of tumors [ 28 , 38 ]. They also have important regulatory effects on bone metabolism.…”

Section: Introductionmentioning

confidence: 99%

Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China

et al. 2021

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Introduction Steroid-induced osteonecrosis of the femoral head (ONFH) is a disease of the bone. Metabolism and genetic factors are generally considered to play an important role. The purpose of this study was to investigate the relationship between single-nucleotide polymorphisms (SNPs) in MIR17HG and MIR155HG and the risk of steroid-induced ONFH in the population of northern China. Methods A total of 199 steroid-induced ONFH patients and 506 healthy controls were recruited for the study. Four SNPs of MIR17HG and seven SNPs of MIR155HG were genotyped by Sequenom MassARRAY. ORs and 95% CIs were used to evaluate the relationship between these SNPs and steroid-induced ONFH. Results In the codominant model, patients with the MIR17HG SNPs (rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.79, p = 0.039); in the recessive model, patients with the MIR17HG SNP (rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.78, p = 0.032). Stratified analysis showed that a MIR17HG SNP (rs7318578) and the MIR155HG SNPs (rs77218221, rs11911469, rs34904192 and rs4143370) were closely related to different unornamented phenotypes of steroid-induced ONFH. Analysis of the clinical indicators revealed significant differences in high-density lipoprotein (HDL-C) levels between the ONFH group and the control group (p = 0.005). In the MIR17HG SNP (rs75267932), patients with different genotypes had different levels of triglyceride (TG). The MIR155HG SNPs (rs77699734, rs1893650, and rs34904192) showed differences in triglyceride (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) levels in patients with different genotypes. Conclusion Our results confirm that MIR17HG and MIR155HG gene mutations are associated with steroid-induced ONFH susceptibility in the population of northern China, providing new evidence for the early detection and prevention of ONFH.

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Analysis of the relationship between MIR155HG variants and gastric Cancer susceptibility

Cited by 11 publications

References 32 publications

Improved therapeutic effects on vascular intimal hyperplasia by mesenchymal stem cells expressing MIR155HG that function as a ceRNA for microRNA‐205

Improved therapeutic effects on vascular intimal hyperplasia by mesenchymal stem cells expressing MIR155HG that function as a ceRNA for microRNA‐205

The Single Nucleotide Polymorphisms rs4143370 and rs34904192 in MIR155HG Were Associated with Esophageal Cancer Risk in the Chinese Han Population

Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China

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