Analysis of the surgical treatment of the patients operated on by using laparoscopic and classic splenectomy due to benign disorders of the spleen

Milosavljević, Vladimir; Tadić, Boris; Grubor, Nikola; Eric, Dragan; Reljic, Milorad; Matić, Slavko

doi:10.5578/turkjsurg.4324

Cited by 4 publications

(7 citation statements)

References 16 publications

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“…Therefore, we firmly believe that having a preoperative pathohistological finding is not going to change the corresponding treatment or the surgical outcome. Splenectomy, either open or laparoscopic, is at the same time the best diagnostic and therapeutic method [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Isolated Splenic Metastasis of Primary Lung Cancer Presented as Metachronous Oligometastatic Disease—A Case Report

et al. 2022

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Modern oncology practice and new antitumor drugs prolonged disease-free intervals in patients with lung cancer. Patients with distant metastatic disease are treated only with palliative intent. The International Association for the Study of Lung Cancer, in the 8th edition of the TNM classification, for the first time includes oligometastatic disease as a clinical state that describes the patients with distant metastasis, limited in number and organ sites, who may have more indolent biology. In this paper, we present a case of a 56-year-old man who was admitted to our clinic regarding a radiologically diagnosed splenic lesion of uncertain nature, and who underwent a left upper lobectomy for primary lung cancer 12 years before. After a detailed radiological diagnosis, it was concluded that it is highly suspected metastatic lesion of the spleen and the patient underwent a splenectomy. While no definitive protocols exist on the management of isolated splenic metastasis from lung cancer, splenectomy, in suitable patients, with reasonable survival expectations, improves patient disease-free survival and can prevent potentially life-threatening complications, such as splenic rupture. 18F-FDG PET has very high sensitivity and specificity for differentiating benign and malignant splenic lesions especially in patients who are in the follow up protocol due to primary malignancy.

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Section: Discussionmentioning

confidence: 99%

Isolated Splenic Metastasis of Primary Lung Cancer Presented as Metachronous Oligometastatic Disease—A Case Report

et al. 2022

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“…As in the case of other benign splenic tumors, splenectomy is the only curative treatment modality to be applied for MAE [2,17]. According to the literature data presented so far in Table 1, out of a total of eight cases, only one underwent laparoscopic splenectomy.…”

Section: Discussionmentioning

confidence: 99%

Report on four cases of the rarest benign splenic tumor - myoid angioendothelioma, with literature review

Milosavljević¹,

Grubor

Matić

et al. 2021

Srp Arh Celok Lek

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Introduction. Myoid angioendothelioma of the spleen is an extremely rare form of a benign splenic tumor. There is no characteristic symptomatology for this disease. Case outline. We present four patients operated on for myoid angioendothelioma of the spleen. Three patients were without problems while one had nonspecific problems. Two patients underwent laparoscopic surgery and two underwent open splenectomy. In all patients, the definitive diagnosis was confirmed by histopathological examination. Discussion. By reviewing the aforementioned medical databases of published papers in English, we found a total of eight cases of myoid angioendothelioma of the spleen. In addition to the mentioned number, we have added our series of cases. Conclusion. Twenty-one years after the discovery of myoid angioendothelioma of the spleen, the small number of cases presented in the literature is still a limiting factor in making conclusions and in learning lessons about this disease

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“…In the years that followed, although still prior to the introduction of novel therapy in the treatment of AIHA and underling diseases, the reported median time from AIHA diagnosis to splenectomy extended and the laparoscopic procedure prevailed over the open-surgery technique [ 99 , 100 ]. Due to the rarity of AIHA, patients with secondary AIHA were included in most published studies.…”

Section: The Place Of Splenectomy In the Era Of Novel Aiha Treatmentmentioning

confidence: 99%

“…In addition to the abovementioned study conducted by Serbian authors, which compared the safety of laparsacopic and open techniques [ 99 ], by searching the Medline database, we managed to identify three studies published in English after 2012 that related to splenectomy in AIHA adult humans, and one study related to splenectomy in adults with Evans syndrome. Maskal et al reported a short-term complete response of 61% and a complete response of 43% after a median follow up period of 33 months in splenectomized patients with primary and secondary AIHA [ 108 ].…”

Section: The Place Of Splenectomy In the Era Of Novel Aiha Treatmentmentioning

confidence: 99%

“…In a Spanish multicenter retrospective study of 93 patients diagnosed with AIHA between 1987 and 2017, the third line of therapy, including splenectomy, was needed in only 27% of patients, and a decrease in the rate of splenectomy was observed after the successful introduction of rituximab, which was applied in 34 patients with an overall response rate of close to 100% [60]. In addition to the abovementioned study conducted by Serbian authors, which compared the safety of laparsacopic and open techniques [99], by searching the Medline database, we managed to identify three studies published in English after 2012 that related to splenectomy in AIHA adult humans, and one study related to splenectomy in adults with Evans syndrome. Maskal et al reported a short-term complete response of 61% and a complete response of 43% after a median follow up period of 33 months in splenectomized patients with primary and secondary AIHA [108].…”

Section: The Place Of Splenectomy In the Era Of Novel Aiha Treatmentmentioning

confidence: 99%

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The Role of the Spleen and the Place of Splenectomy in Autoimmune Hemolytic Anemia—A Review of Current Knowledge

Cvetković,

Pantić,

Cvetković

et al. 2023

Diagnostics

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Autoimmune hemolytic anemia (AIHA) is a rare, very heterogeneous, and sometimes life-threatening acquired hematologic disease characterized by increased red blood cell (RBC) destruction by autoantibodies (autoAbs), either with or without complement involvement. Recent studies have shown that the involvement of T- and B-cell dysregulation and an imbalance of T-helper 2 (Th2) and Th17 phenotypes play major roles in the pathogenesis of AIHA. AIHA can be primary (idiopathic) but is more often secondary, triggered by infections or drug use or as a part of other diseases. As the location of origin of autoAbs and the location of autoAb-mediated RBC clearance, as well as the location of extramedullary hematopoiesis, the spleen is crucially involved in all the steps of AIHA pathobiology. Splenectomy, which was the established second-line therapeutic option in corticosteroid-resistant AIHA patients for decades, has become less common due to increasing knowledge of immunopathogenesis and the introduction of targeted therapy. This article provides a comprehensive overview of current knowledge regarding the place of the spleen in the immunological background of AIHA and the rapidly growing spectrum of novel therapeutic approaches. Furthermore, this review emphasizes the still-existing expediency of laparoscopic splenectomy with appropriate perioperative thromboprophylaxis and the prevention of infection as a safe and reliable therapeutic option in the context of the limited availability of rituximab and other novel therapies.

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Analysis of the surgical treatment of the patients operated on by using laparoscopic and classic splenectomy due to benign disorders of the spleen

Abstract: Analysis of the surgical treatment of the patients operated on by using laparoscopic and classic splenectomy due to benign disorders of the spleen.

Cited by 4 publications

References 16 publications

Isolated Splenic Metastasis of Primary Lung Cancer Presented as Metachronous Oligometastatic Disease—A Case Report

Isolated Splenic Metastasis of Primary Lung Cancer Presented as Metachronous Oligometastatic Disease—A Case Report

Report on four cases of the rarest benign splenic tumor - myoid angioendothelioma, with literature review

The Role of the Spleen and the Place of Splenectomy in Autoimmune Hemolytic Anemia—A Review of Current Knowledge

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