Analysis of the Variation in Corneal Parameters with regard to Refractive Error in Saudi Arabian Adults

Alkhaldi, Saleh A.

doi:10.34297/ajbsr.2021.14.002025

Cited by 2 publications

(2 citation statements)

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Section: Introductionmentioning

confidence: 99%

“…On the other hand, a study reported that the mean spherical equivalent was significantly associated with the changes in corneal curvature and ECD. However, CCT and the COV of cell volume were in the normal range and were poorly correlated with respect to changes in mean spherical equivalent (MSE) [12]. Thomas et al [13] observed that in cases of high myopia, the elongation of the eyeball leads to a decrease in both central corneal thickness and mean endothelial cell density.…”

Section: Introductionmentioning

confidence: 99%

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Morphology and thickness of corneal endothelial cells in young Sudanese individuals with myopia

Mutwaly,

Alrasheed,

Elmadina

et al. 2023

JMedLife

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Deviations in corneal endothelium morphology and thickness may indicate corneal abnormalities and could be associated with myopia development. This study aimed to evaluate corneal endothelial cell morphology and central corneal thickness in young individuals with myopia. A prospective study was conducted at Al-Neelain University Eye Hospital between January 2019 and January 2020, including 160 patients with myopia (320 eyes). Data was gathered through clinical assessment of visual acuity, refractive error, and corneal endothelial cells. Results showed that 60% of participants with myopia were female, with a mean age of 21.99±2.8 years and a mean equivalent sphere of -3.19±2.67D. There was a significant difference in endothelial cell degeneration between myopia groups (P<0.001). Corneal guttata occurred in 9.1% of eyes with low myopia and 68.2% with moderate myopia, whereas polymegathism and polymorphism were more prevalent in high myopia. The mean central corneal thickness was 500.50±38.94 µm in low myopia, 497.02±36.23 µm in moderate myopia, and 477.87±43.625 µm in high myopia (P=0.007). The mean endothelial cell number in low myopia was 107.86±21.12, 106.0±24.03 in moderate myopia, and 101.23±18.49 in high myopia (P<0.05). The mean difference in endothelial cell density, coefficient of variation, and hexagonality in low, moderate, and high myopia was not significant (P>0.05). However, Pearson’s correlation revealed a significant negative correlation between the degree of myopia and central corneal thickness (r= -0.174, P=0.002) as well as endothelial cell number (r= -0.124, P=0.026). The study concluded that central corneal thickness and endothelial cell number significantly decreased with an increase in the degree of myopia. Corneal guttata was the most common form of endothelial cell degeneration observed in cases of high myopia.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%