Analysis of Tumor Marker CA 125 in Saliva of Normal and Oral Squamous Cell Carcinoma Patients: A Comparative Study

Balan, Jude J; Rao, Roopa S; Premalatha, B R; Patil, Shankargouda

doi:10.5005/jp-journals-10024-1207

Cited by 35 publications

(38 citation statements)

References 15 publications

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“…Our study identified new mutations in these molecules and also discovered increased copy number of MUC2, MUC4 and MUC6. A few other studies have reported an association between elevated MUC16 level and progression of oral squamous cell carcinomas and thyroid neoplasm272829. In addition to the mucins, SIRPA displayed somatic mutations, copy number gain and corresponding overexpression in the progressive stages of this subject and the majority of the additional HPVOPC subjects analyzed.…”

Section: Discussionmentioning

confidence: 61%

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Genetic Mutation and Exosome Signature of Human Papilloma Virus Associated Oropharyngeal Cancer

Kannan

Hertweck

Philley

et al. 2017

Sci Rep

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Human papilloma virus-16 (HPV-16) associated oropharyngeal cancer (HPVOPC) is increasing alarmingly in the United States. We performed whole genome sequencing of a 44 year old, male HPVOPC subject diagnosed with moderately differentiated tonsillar carcinoma. We identified new somatic mutation in MUC16 (A.k.a. CA-125), MUC12, MUC4, MUC6, MUC2, SIRPA, HLA-DRB1, HLA-A and HLA-B molecules. Increased protein expression of MUC16, SIRPA and decreased expression of HLA-DRB1 was further demonstrated in this HPVOPC subject and an additional set of 15 HPVOPC cases. Copy number gain (3 copies) was also observed for MUC2, MUC4, MUC6 and SIRPA. Enhanced expression of MUC16, SIRPA and HPV-16-E7 protein was detectable in the circulating exosomes of numerous HPVOPC subjects. Treatment of non-tumorigenic mammary epithelial cells with exosomes derived from aggressive HPVOPC cells harboring MUC16, SIRPA and HPV-16-E7 proteins augmented invasion and induced epithelial to mesenchymal transition (EMT) accompanied by an increased expression ratio of the EMT markers Vimentin/E-cadherin. Exosome based screening of key HPVOPC associated molecules could be beneficial for early cancer diagnosis, monitoring and surveillance.

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Section: Discussionmentioning

confidence: 61%

“…The highest frequency of somatic mutations spanning the coding regions (CDS) was observed in a panel of genes involved in various pathways associated with malignant progression23242526272829. These molecules include MUC16 (A.k.a.…”

Section: Resultsmentioning

confidence: 99%

Genetic Mutation and Exosome Signature of Human Papilloma Virus Associated Oropharyngeal Cancer

Kannan

Hertweck

Philley

et al. 2017

Sci Rep

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“…Also the levels salivary CA-125 were seen to be reduced significantly postoperatively in patients of group 5 (888.15 mg/dl) as compared to patients with oral malignancy in group 4 (1362.2 mg/dl) Balan et al [13] in a similar study observed the mean salivary CA 125 values of OSCC patients as 320. 25 and that of control group as 33.14 (p<0.05).…”

Section: Variablesmentioning

confidence: 80%

“…The resulting supernatant fluid was subjected to ELISA for assessment of CA 125 and LDH levels. [13] Statistical analysis: The collected data was coded and entered in Microsoft Excel sheet. Mean, SD and Median was calculated for quantitative data.…”

Section: Methodsmentioning

confidence: 99%

Utility Of Salivary CA-125 And LDH As Tumor Markers In Oral Malignancy

Yadav

Ja²,

Ar³

et al. 2018

IJCBR

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Background:The mortality and morbidity associated with oral Squamous cell carcinoma (OSCC) can be greatly reduced if tumor markers which can detect OSCC at an early stage are available. This study attempts to use saliva as the diagnostic medium to determine the correlation of salivary CA 125 and LDH in tobacco users with and without potentially malignant disorders. Changes in CA 125 and LDH level can be used as a marker in patients with and without premalignant disease and can be used as a deterrent in continuation of the habit. Aims: To assess the role of CA 125 & LDH as a tumour marker in Oral cancer patients. Materials and methods: Cross sectional observational study .Time period: December 2015 to August 2017.Study area: OPD of tertiary care hospital in pune. Total participants: 150 persons. Under non-stimulatory conditions whole saliva sample was collected from each individual and was centrifuged. The resulting supernatant was used for estimation of CA 125 and LDH levels. Results: In present study, mean Salivary LDH level was found to be lowest among cases of healthy individuals while it was highest among individuals who were diagnosed and underwent treatment for malignancy. However there was insignificant difference seen between levels of diagnosed case of oral malignancy and the ones who underwent treatment for oral malignancy. Also mean Salivary CA-125 was lowest in healthy individuals and highest in individuals diagnosed with oral malignancy and the levels were seen to be reduced significantly in the one who underwent treatment for oral malignancies than those who didn't. Conclusion: Salivary CA 125 and LDH has a role in early detection of oral malignancies and can be used as a diagnostic marker. However LDH levels are persistently raised even after treatment for oral malignancy.

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“…CA 125 is a tumor associated antigen which is found to be elevated in the serum and saliva of patients with oral, breast, and ovarian tumors [43]. …”

Section: Potential Biomarkers In Salivamentioning

confidence: 99%

Salivary Diagnostics: A Brief Review

2014

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Early detection of disease plays a crucial role for treatment planning and prognosis. Saliva has great potential as a diagnostic fluid and offers advantage over serum and other biological fluids by an economic and noninvasive collection method for monitoring of systemic health and disease progression. The plethora of components in this fluid can act as biomarkers for diagnosis of various systemic and local diseases. In this review paper, we have emphasized the role of salivary biomarkers as diagnostic tools.

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Analysis of Tumor Marker CA 125 in Saliva of Normal and Oral Squamous Cell Carcinoma Patients: A Comparative Study

Cited by 35 publications

References 15 publications

Genetic Mutation and Exosome Signature of Human Papilloma Virus Associated Oropharyngeal Cancer

Genetic Mutation and Exosome Signature of Human Papilloma Virus Associated Oropharyngeal Cancer

Utility Of Salivary CA-125 And LDH As Tumor Markers In Oral Malignancy

Salivary Diagnostics: A Brief Review

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