A key requirement to provide seamless mobility and guaranteeing Quality of Service in heterogeneous environment is to select the best destination network during handover. In this paper, we propose a new schema for network selection based on Multiple Linear Regression Model (MLRM). A thorough investigation, on a huge live data collected from GPRS/UMTS networks led to identify the Key Performance Indicators (KPIs) that play the most important role in the handover process. These KPIs are: Received Signal Code Power (RSCP), received energy per chip (Ec/No) and Available Bandwidth (ABW) of the destination network. To extract a handover model from collected data, we study the correlation among values of identified KPIs parameters, before, during and after handover, thanks to a statistical learning approach, using the predictive analytics software SPSS. For model assessment, Pearson Correlation Coefficient and determination coefficient Rsquared (R 2 ) are used. Media Independent Handover (MIH) IEEE 802.21 standard is used in this work to retrieve the lower layer information of available networks and announce the handover needs (handover initiation). The proposed model will help to select the most appropriate network between many existing ones in the vicinity of the mobile node.