Analysis of wound discharge microbiota in patients with drug-associated osteonecrosis of the jaw

Abstract

Introduction. Chronic forms of inflammatory periodontal diseases, leading to deterioration of bone tissue quality and volume, are the most important and urgent problems for modern dentistry. Despite the measures taken at different levels of prevention the tendency to the increase of patients with periodontitis has been revealed. The aim of the investigation was to make a comparative clinical and radiological evaluation of the effectiveness of directed tissue regeneration (DTR) using different methods of membrane placement in the area of defects with complex configuration in patients with moderate-to-severe chronic periodontitis. Material and methods. Patients were divided into two groups of 30 patients each. Study design: open randomized. Patients of the first group were operated on using DTR technique and additional membrane fixation by means of periodontal micropins; patients of the second group were operated on using DTR without additional membrane fixation. The results were assessed by clinical and radiological examination after 1, 3, 6 and 12 months. Results. More active regenerative processes were registered in the first group; the periodontal pocket depth after one month was 2,77 ± 0,08 mm, in patients of the second group – 2,85 ± 0,03 mm (p < 0,05); the tendency for decrease of this index remained during all investigation. The Hounsfield index after 12 months was 1658 ± 45.38 units in the first group and 1589 ± 12.02 units in the second group (p < 0.05). Discussion. When comparing the obtained data with those of their foreign colleagues, the authors concluded that additional fixation of the membrane leads to a less pronounced deformation and preservation of the bone volume in the long-term postoperative period. Conclusion. The use of micropins for membrane fixation allows to work with defects of complex configuration and in the long term leads to formation of denser bone tissue with preservation of its volume.