In order to evaluate the impact of crankshaft structure parameters on the transition strength of main journal and crank arm, this paper takes the crankshaft of V8 engine as the research object, using the finite element method to analyze, and then processing the experimental results with orthogonal experimental method throughout the experimental design, with the crankshaft parameters’ significant analysis of the crank arm overlap degree, main journal diameter, main journal length, crank pin diameter, crank pin length, etc, to obtain their impacts on the strength, and provide the instructive recommendations of crankshaft design and optimization.