Abstract. We consider toroidal pseudodifferential operators with operator-valued symbols, their mapping properties and the generation of analytic semigroups on vector-valued Besov and Sobolev spaces. We show that a parabolic toroiodal pseudodifferential operator generates an analytic semigroup on the Besov space B s pq (T n , E) and on the Sobolev space W k p (T n , E), where E is an arbitrary Banach space, 1 ≤ p, q ≤ ∞, s ∈ R and k ∈ N0. For the proof of the Sobolev space result, we establish a uniform estimate on the kernel which is given as an infinite parameterdependent sum. An application to abstract non-autonomous periodic pseudodifferential Cauchy problems gives the existence and uniqueness of classical solutions for such problems.