Analytical and compositional aspects of isoflavones in food and their biological effects

Mortensen, Alicja; Kulling, Sabine E.; Schwartz, Heidi; Rowland, Ian; Ruefer, Corinna E.; Rimbach, Gerald; Cassidy, Aedín; Magee, Pamela; Millar, Julie; Hall, Wendy L.; Birkved, Franziska Kramer; Sørensen, Ilona Kryspin; Sontag, Gerhard

doi:10.1002/mnfr.200800478

Cited by 153 publications

(175 citation statements)

References 503 publications

(450 reference statements)

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“…1,2 Soy is a staple of many traditional Asian diets. 3,4 High soy intake may reduce the risk of some chronic diseases among Asian women compared with their Western counterparts, and soy products are suggested as a treatment option for menopausal vasomotor symptoms. 5,6 Soy isoflavones may also benefit cognitive health in postmenopausal women, but evidence from adequately powered clinical trials is lacking.…”

Section: Classification Of Evidencementioning

confidence: 99%

“…This study of healthy midlife and older women was designed to assess the effects of dietary supplementation with isoflavone-rich soy protein (ISP) containing naturally occurring isoflavones in quantities within the upper range of traditional Asian diets. 3,4 The primary WISH trial endpoint was the effect of ISP compared with placebo on progression of subclinical atherosclerosis. 18 A secondary endpoint, reported here, was the ISP effect on cognitive change.…”

Section: Classification Of Evidencementioning

confidence: 99%

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Long-term soy isoflavone supplementation and cognition in women

Henderson

John²,

Hodis³

et al. 2012

Neurology

107

106

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Objective: To determine the cognitive effects of long-term dietary soy isoflavones in a daily dose comparable to that of traditional Asian diets. Methods:In the double-blind Women's Isoflavone Soy Health trial, healthy postmenopausal women were randomly allocated to receive daily 25 g of isoflavone-rich soy protein (91 mg of aglycone weight of isoflavones: 52 mg of genistein, 36 mg of daidzein, and 3 mg glycitein) or milk proteinϪmatched placebo. The primary cognitive endpoint compared between groups at 2.5 years was change from baseline on global cognition, a composite of the weighted sum of 14 neuropsychological test score changes. Secondary outcomes compared changes in cognitive factors and individual tests. Results:A total of 350 healthy postmenopausal women aged 45-92 years enrolled in this trial; 313 women with baseline and endpoint cognitive test data were included in intention-to-treat analyses. Adherence in both groups was nearly 90%. There was no significant between-group difference on change from baseline in global cognition (mean standardized improvement of 0.42 in the isoflavone group and 0.31 in the placebo group; mean standardized difference 0.11, 95% confidence interval [CI] Ϫ0.13 to 0.35). Secondary analyses indicated greater improvement on a visual memory factor in the isoflavone group (mean standardized difference 0.33, 95% CI 0.06-0.60) but no significant between-group differences on 3 other cognitive factors or individual test scores, and no significant difference within a subgroup of younger postmenopausal women. Conclusion:For healthy postmenopausal women, long-term dietary soy isoflavone supplementation in a dose comparable to that of traditional Asian diets has no effect on global cognition but may improve visual memory. Isoflavones are plant-derived diphenolic micronutrients with structural similarities to steroidal estrogens. Soybeans (Glycine max) and soy-based food products are the major dietary source of isoflavones. The primary soy isoflavones, genistin, daidzin, and glycitin, are hydrolyzed within the intestines to their respective aglycones (genistein, daidzein, and glycitein) before systemic absorption. Classification of evidence:

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Section: Classification Of Evidencementioning

confidence: 99%

Section: Classification Of Evidencementioning

confidence: 99%

Long-term soy isoflavone supplementation and cognition in women

Henderson

John²,

Hodis³

et al. 2012

Neurology

107

106

View full text Add to dashboard Cite

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“…Precisamente el interés por la soja en Occidente se originó tras la observación de una menor incidencia de síntomas vasomotores durante el climaterio en mujeres asiáticas, y que se atribuyó al diferente contenido en isoflavonas en la dieta entre las dos culturas: la ingesta de isoflavonas en Occidente se encuentra entre 0,1-3,3 mg/día (9-11), frente a los 8-50 mg/día en los países asiáticos, pudiendo llegar en Japón hasta 76 mg/día (10,11). Este hecho ha llevado a la realización de numerosos estudios para evaluar el papel de las isoflavonas sobre los síntomas climatéricos, así como el papel protector frente a la descalcificación ósea y la reducción de los marcadores de cardiopatía isquémica en mujeres peri y postmenopáusicas.…”

Section: Isoflavonas De La Sojaunclassified

Beneficios de la soja en la salud femenina

Salinas

López-Sobaler

2017

Nutr Hosp

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Martín Salinas C, López-Sobaler AM. Beneficios de la soja en la salud femenina. Nutr Hosp 2017;34(Supl. AbstractA great interest has been developed last decades on the role of phytoestrogens as an alternative to hormone replacement therapy. In fact, numerous studies have shown the effects of soy isoflavones on climacteric symptomatology by significantly reducing the frequency and intensity of hot flashes, as well on cardiovascular health. The aim of this paper was to review the last studies, mainly randomized controlled trials, on the effect of isoflavones on climacteric symptoms and their impact on women's quality of life, as well as on other health markers. Following a review of meta-analyzes and recent clinical trials, evidence has been obtained of the efficacy of isoflavones use in reducing hot flashes, improving the quality of life, lowering the cardiovascular risk by optimizing lipid profile, and Improving bone mineral density and other markers of bone resorption. Most of the authors concluded on the favorable effect of regular consumption of soy isoflavones on the health and quality of life of peri and postmenopausal women.Beneficios de la soja en la salud femenina ResumenDesde hace varias décadas, se ha desarrollado un gran interés por el papel de los fitoestrógenos como alternativa a la terapia hormonal sustitutiva. De hecho, numerosos estudios han determinado los efectos de las isoflavonas de soja sobre la sintomatología climatérica al reducir significativamente la frecuencia e intensidad de los sofocos. Este resultado se ha observado también sobre la salud cardiovascular. El objetivo de este trabajo ha sido revisar los estudios publicados, principalmente ensayos clínicos aleatorizados y controlados sobre el efecto de las isoflavonas en los síntomas climatéricos y su repercusión en la calidad de vida de la mujer, así como en otros marcadores de salud. Tras una revisión de metaanálisis y ensayos clínicos recientes, se ha obtenido evidencia de la eficacia del consumo de isoflavonas en la reducción de los sofocos con una mejora de la calidad de vida, en la disminución del riesgo cardiovascular por optimización del perfil lipídico, y en la mejoría de la densidad mineral ósea y otros marcadores de resorción ósea. La mayoría de los autores concluyen en el efecto favorable de un consumo regular de isoflavonas de soja sobre la salud y la calidad de vida de la mujer peri y postmenopáusica.

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“…30 kullanılmaktadır (8). Laktasyon süresince sütü artırıcı ve kolesterol seviyesini düşürücü etkileri yanısıra menopozal semptomlar (7), bazı kanserler (9), koroner hastalıklar (10), osteoporoz (11), anemi, diyabet ve ülser gibi pek çok hastalığın etkilerini azaltıcı ve önleyici rol oynamaktadır (12,13). Farmakolojik çalışmalar yaygın tür olan Medicago sativa bitkisinin antioksidan (14), anti bakteriyel (15), antikanser (16), antihiperlipidemik (17) ve anksiyolitik (18) aktiviteler gibi önemli biyolojik aktivitelere sahip olduğunu göstermiştir.…”

Section: Introductionunclassified