Analytical approach on leaflet flutter on biological prosthetic heart valves

Avelar, Artur Henrique de Freitas; Stófel, Mairon A. G. E.; Canestri, Jean A.; Huebner, Rudolf

doi:10.1007/s40430-017-0908-4

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Turbulent flow, which may be further amplified by leaflet flutter (27), has also been linked to blood damage, including platelet activation, thrombosis, and hemolysis (28,29). A recent analytical study proposed a mathematical model to predict the critical flow speed of flutter onset as a function of valve properties, including tissue thickness (30). In terms of quantifying leaflet flutter, recent experimental work has proposed different methods to track the leaflet free-edge motion with varying levels of accuracy (21,31,32).…”

Section: Strain Distributionmentioning

confidence: 99%

Thinner biological tissues induce leaflet flutter in aortic heart valve replacements

Johnson

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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Valvular heart disease has recently become an increasing public health concern due to the high prevalence of valve degeneration in aging populations. For patients with severely impacted aortic valves that require replacement, catheter-based bioprosthetic valve deployment offers a minimally invasive treatment option that eliminates many of the risks associated with surgical valve replacement. Although recent percutaneous device advancements have incorporated thinner, more flexible biological tissues to streamline safer deployment through catheters, the impact of such tissues in the complex, mechanically demanding, and highly dynamic valvular system remains poorly understood. The present work utilized a validated computational fluid–structure interaction approach to isolate the behavior of thinner, more compliant aortic valve tissues in a physiologically realistic system. This computational study identified and quantified significant leaflet flutter induced by the use of thinner tissues that initiated blood flow disturbances and oscillatory leaflet strains. The aortic flow and valvular dynamics associated with these thinner valvular tissues have not been previously identified and provide essential information that can significantly advance fundamental knowledge about the cardiac system and support future medical device innovation. Considering the risks associated with such observed flutter phenomena, including blood damage and accelerated leaflet deterioration, this study demonstrates the potentially serious impact of introducing thinner, more flexible tissues into the cardiac system.

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Section: Strain Distributionmentioning

confidence: 99%

Thinner biological tissues induce leaflet flutter in aortic heart valve replacements

Johnson

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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Recent Computational Investigations of Leaflet Flutter in Thinner Biological Heart Valve Tissues

Johnson

2023

Modeling and Simulation in Science, Engineering and Technology

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Self-excited flapping motion of wall-mounted valvular leaflets in a three-dimensional channel flow

Wang,

Nitti,

de Tullio

2024

Physics of Fluids

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The onset of flow-induced oscillations in valve-like configurations remains not completely understood, despite the wide relevance in fluid transport across human physiology and various industrial applications. The present work explores the excitation mechanisms of self-sustained oscillation with key operating parameters in a general-purpose configuration by means of high-fidelity simulations. The investigation is carried out with a partitioned framework that resolves the fluid field by a finite-difference fractional step scheme, discretizes the structural domain via an isogeometric method, and considers an immersed boundary forcing through the interpolation/spreading kernel built by moving-least squares. Our findings confirm the onset of flapping motion in valvular shells, jointly influenced by geometric parameters, structural properties, and flow conditions. Specifically, at a Reynolds number (Re) of 800 and shell aspect ratio of 1.0, a critical reduced velocity exists at around 6, bifurcating static and periodic oscillation modes. After this criterion, flexible shells flutter in the third-plate-mode natural frequency, with oscillation amplitudes approaching an asymptotic value, coupled with intensified vortex shedding, as the reduced velocity increases. Re mainly imparts a destabilizing effect on the fluid-shell system; a lower Re suppresses flow-induced vibrations through viscous dissipation, while a higher Re introduces three-dimensional complexities, asymmetrical oscillations, and quasi-periodicity in the flapping dynamics, especially within the critical regime of reduced velocity. The impact of shell aspect ratio is intricate; in contrast, the case with an aspect ratio of 1.3 displays more intensive flapping motion compared to the reference case of 1.0, whereas further increasing to 1.6 mainly shows stabilizing effects in the shell dynamics.

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Analytical approach on leaflet flutter on biological prosthetic heart valves

Cited by 3 publications

References 36 publications

Thinner biological tissues induce leaflet flutter in aortic heart valve replacements

Thinner biological tissues induce leaflet flutter in aortic heart valve replacements

Recent Computational Investigations of Leaflet Flutter in Thinner Biological Heart Valve Tissues

Self-excited flapping motion of wall-mounted valvular leaflets in a three-dimensional channel flow

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