Analytical approaches for clarification of DNA-double decker phthalocyanine binding mechanism: As an alternative anticancer chemotherapeutic

DNA binding studies of the 2,10,16,24–tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compounds

“…It is already known that intercalative chemical compounds cause a substantial enhancement in the viscosity of the DNA molecule owing to the extension of the DNA molecule by fitting among DNA base pairs [41]. According to reported study in literature, the findings of study demonstrated that the relative viscosity of DNA scales up as amount of complex increases that is a sign of intercalative binding mechanism [10]. Adversely, the non-intercalative binding mechanisms cause a decrease in the viscosity of DNA [42].…”

“…According to reported study in the literature found that DNA binding activity like intercalative interaction mostly is connected with red shift and hypochromicity. Another study in the literature showed that intercalative binding of tiny molecules leads to hyperchromism because of strong packing of aromatic ring to DNA base pairs [10]. Both phthalocyanine compounds indicated hypochromicity, where dropping in absorbance is defined as hypochromicity, and increasing in absorbance is called as hyperchromicity, with the increase in the amounts of the DNA as illustrated in Figs.…”

“…A study was reported in literature to determine the binding mechanism by using fluorescence titration method. The result of the study showed that the intensity of emission spectra of DNA considerably decreases in the presence of an intercalative molecule that refers intercalative binding mechanism [10]. Figures 6 and 7 display the emission titration spectra of 4 and 5 in the presence of the DNA in a buffer solution at a pH of 7.02.…”

“…Recently, many people struggle with deadly cancer diseases, and a great number of people die because of cancer [9]. In the literature, studies have shown that cancers are very dangerous medical issues in the world, and it is anticipated that this health problem will continue to cause the deaths of many people in the future [10]. Therefore, designing of new anticancer drugs is highly important to prevent this deadly disease.…”

A Comparative Study on DNA Binding Properties of 2,10,16,24‐Tetrakis 4‐(4‐hydroxyphenyl)‐1‐phenylethyl) phenoxy)‐Substituted Co(II) and Mg(II) Phthalocyanine Compounds

“…Even though there is great progress in the individualized cancer treatment, such medicines involve only a small percentage of the total anticancer drugs . Recently, scientists have been focusing on developing DNA damaging medicines for cancer treatment ,. Since the molecular recognition of DNA is essential for the interaction of transition metal compounds with DNA, it continues to be a significant field of research .…”