Analytical bias due to calibrator matrix effects

Saibaba, K. S. S.; Rao, Pragna; Ramana, G. V.; Kumar, E.G.T.V.; Tripathi, Rajesh

doi:10.1007/bf02871014

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…A few examples of random errors are pipetting error, transcription error, wrong sample numbering and labeling, and fluctuating readings on the colorimeter. Systematic errors could occur due to wrong procedure, incorrect standards and calibration procedures [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Errors in the Hematology Laboratory at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

et al. 2018

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ObjectiveThe objective of this study was to determine the magnitude of pre-analytical, analytical and post-analytical laboratory errors in hematology tests.ResultsA total of 2606 hematology requests were studied. Out of the total, 562 (21.6%) pre-analytic, 14 (0.5%) analytical and 168 (6.4%) post-analytical errors were recorded which contribute a total frequency of 75.5, 1.9 and 22.6%, respectively. The name of the physician requesting the test was not provided on 2215 (85%) of request forms and 1827 (70.1%) of the request forms were unaccompanied with proper clinical details of the patient. Essential information required on the request forms was often missed. Close communication between clinicians and laboratory personnel is the key to improve laboratory quality in general.

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Section: Introductionmentioning

confidence: 99%

Errors in the Hematology Laboratory at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

et al. 2018

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“…Matrix effects can also cause nonlinearity in biochemical analysis. Recently we have reported the interference caused by matrix effects by analysing fresh serum specimens using calibration with serum matrix calibrator as well as aqueous matrix calibrator (13). Despite good correlation, there was statistically significant bias between the two calibrations for most of the analytes.…”

Section: A Exogenous Interferentsmentioning

confidence: 99%

Interferences in clinical chemistry analysis

Saibaba¹,

Bhaskar²,

Rao³

et al. 1998

Indian J Clin Biochem

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Analyses of body fluids in clinical chemistry laboratory are subject to a number of interferences that affect the analytical accuracy. The interferents arise from exogenous sources like drugs and additives as well as such endogenous sources like lipemia, hemolysis and icteria. Our studies demonstrate matrix interference in the form of analytical bias between serum and aqueous matrix calibrators. The clinical chemist should constantly be aware of this factor. Correction of interferences is recommended as an integral part of the quality assurance program.

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Method evaluation of an enzymatic method for serum creatinine

Saibaba

Rao

Murty

et al. 1997

Indian J Clin Biochem

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Selecting the correct method for routine analysis by 'method evaluation' is an important component of quality assurance. It is a step-wise procedure that evaluates various analytical parameters like accuracy, precision etc of the given method. Finally reference intervals are established for selected population, we evaluated an enzymatic method for serum creatinine. The results show that it is an acceptable method based on the above mentioned criteria.

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Analytical bias due to calibrator matrix effects

Cited by 3 publications

References 2 publications

Errors in the Hematology Laboratory at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

Errors in the Hematology Laboratory at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

Interferences in clinical chemistry analysis

Method evaluation of an enzymatic method for serum creatinine

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