Analytical Modeling of Sensitivity Parameters Influenced by Practically Feasible Arrangement of Bio-Molecules in Dielectric Modulated FET Biosensor

Abstract

In this paper, analytical modeling of a Dielectric Modulated Double Gate Field Effect Transistor (DM-DGFET) for biosensing application is presented with extensive data analysis. Firstly, the size of the nanogaps and arrangements of biomolecules in those gaps are optimized with respect to the sensitivity of the above sensor. The optimized DM-DGFET is next analyzed on the basis of its modeling and simulation. This paper addresses novel issues arising from arrangements of biomolecules, especially from practical point of view. Effect of probe placement due to steric hindrance and random nature of biomolecules, are also considered. The capacitances associated with the nanogaps occupied by biomolecules, following various arrangements, are modeled. Expressions of the threshold voltage, drain current and its sensitivity in terms of variations are also derived using the capacitance model. A comparative study of the proposed and the existing architectures is made. The influence of process variation on the sensitivity of the sensor is also studied. The results from the proposed analytical model are validated with the simulated data obtained from TCAD device simulator. In conclusion, the proposed DM-DGFET based biosensor architecture will emerge as an optimal model, very useful for the study on this field in future.

2D analytical modelling of asymmetric junctionless dual material double gate MOSFET for biosensing applications considering steric hindrance issue

“…It is observed that in between four step patterns, the decreasing pattern shows almost 17%-21% higher sensitivity compared to other patterns. Table 1 shows the Comparative study of V th and on current sensitivity of AJDMDG MOSFET biosensor and DGFET based bionsensor [42]. As shown in table 1, the sensitivity of the biosensor is higher in decreasing patterns compared to the other patterns, and AJDMDG MOSFET biosensor has better sensitivity in terms of threshold voltage and on current.…”

“…Because of the steric hindrance effect, primarily immobilized biomolecules prevent additional biomolecule entrance [53,54]. As a result, in actuality, partially occupied nanogap holes must be considered since it is critical to existent the issues associated with a random and arbitrary arrangement of biomolecules [42]. However, in this part, numerous nonuniform step patterns of biomolecules within the area of the nanocavity have been studied, and the evaluation of sensitivity for diverse patterns is presented below.…”

“…Biosensor design mostly covers with totally filled cavities [40,41], however, significance of moderately filled cavity plays crucial role than the reported structures as the collection of biomolecules inside the cavity is irregular and composite owing to low binding probability and surface functionality [42]. Additionally, the cavity cannot be completely filled due to the steric hindrance issue [43].…”

“…Comparative study of sensitivity analysis of AJDMDG MOSFET based biosensor and DGFET based bionsensor[42].…”

A detailed investigation of dielectric-modulated dual-gate TMD FET based label-free biosensor via analytical modelling

“…Model of drain current in subthreshold region is calculated by utilizing expressions of surface potential obtained in previous section 45 and can be expressed as, (35) www.nature.com/scientificreports/ For linear regime, three transistor modelling approach has been employed to calculate the drain current 46 . Both the subthreshold current and linear regime current have been equated at transition region for the continuity of the current.…”