Analytical Potentialities of Carbon Nanotube/Silicone Rubber Composite Electrodes: Determination of Propranolol

Santos, Sidney Xavier dos; Cavalheiro, Éder Tadeu Gomes; Brett, Christopher M.A.

doi:10.1002/elan.201000262

Cited by 31 publications

(19 citation statements)

References 42 publications

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“…26,27 Two possible mechanisms for the electrochemical oxidation of propranolol were proposed in the literature. Bishop and Hussein 28 reported that the hydroxyl group is oxidized, involving 2 protons and 2 electrons.…”

Section: Resultsmentioning

confidence: 99%

Determination of propranolol and hydrochlorothiazide by batch injection analysis with amperometric detection and capillary electrophoresis with capacitively coupled contactless conductivity detection

et al. 2014

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We report two new electrochemical methods for the simultaneous determination of propranolol (PROP) and hydrochlorothiazide (HCT). One method is based on batch injection analysis with multiple pulse amperometric detection (BIA-MPA) and the other on capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C 4 D). The BIA-MPA procedure is highly precise (RSD < 2.1%, n ¼ 10, for both PROP and HCT), fast (130 injections per h) and has low detection limits (0.17 and 1.9 mmol L À1 for PROP and HCT, respectively). The proposed CE-C 4 D method allows the determination of PROP and HCT in less than 1 minute with high precision (RSD < 2.8%, n ¼ 10, for both PROP and HCT) and low detection limits (30 and 10 mmol L À1 for PROP and HCT, respectively). Both of the proposed methods were applied to the determination of PROP and HCT in pharmaceutical samples.

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Section: Resultsmentioning

confidence: 99%

Determination of propranolol and hydrochlorothiazide by batch injection analysis with amperometric detection and capillary electrophoresis with capacitively coupled contactless conductivity detection

et al. 2014

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“…8 shows a comparison of determination of propranolol by oxidation using cyclic, differential pulse and square-wave voltammetry and clearly demonstrates the higher sensitivity of SWV. In another example, thionine was immobilised on CNT before preparing a carbon paste electrode to measure Reproduced with permission from [237] ascorbic acid, acetaminophen and isoniazid simultaneously [238]. In these cases, it is necessary to circumvent the increased tendency for adsorption of organic compounds on the electrode surface.…”

Section: Screen-printed Electrodesmentioning

confidence: 99%

“…For pharmaceutical applications, a CNT/silicone rubber composite electrode was developed for propranolol [237]; Fig. 8 shows a comparison of determination of propranolol by oxidation using cyclic, differential pulse and square-wave voltammetry and clearly demonstrates the higher sensitivity of SWV.…”

Section: Screen-printed Electrodesmentioning

confidence: 99%

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Bioelectroanalysis of pharmaceutical compounds

et al. 2012

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Recent developments in the bioelectroanalysis of pharmaceutical compounds are reviewed, concentrating particularly on the development of electrode materials and measurement strategies and on their application. The advantages of electroanalytical techniques as alternatives to other analytical procedures such as rapid response, sensitivity and low detection limits are highlighted and illustrated. Particular emphasis is given to carbon-based materials for voltammetric electroanalysis; new potentiometric sensors and electrochemical biosensors are also reviewed.

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“…18 The proposed mechanism involves 2 protons and 2 electrons according to: The irreversible oxidation peak observed for metabolites of PRO could be connected with adequate mechanism of oxidation process.…”

Section: Effect Of Phmentioning

confidence: 99%

Electrochemical behavior of Propranolol and its major metabolites, 4'-hydroxypropranolol and 4'-hydroxypropranolol Sulfate, on glassy carbon electrode

Baranowska¹,

Koper²

2011

J. Braz. Chem. Soc.

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Foi estudado o comportamento eletroquímico do propranolol (PRO) e seus principais metabólitos. Medidas voltamétricas foram realizadas em eletrodo de carbono vítreo (GCE). Todos os compostos examinados sofrem oxidação via eletroquímica. Em todos os casos foi observada uma separação dos picos de oxidação, sugerindo a possibilidade de eletroanálise simultânea de propranolol e seus metabólitos. A linearidade das curvas de calibração foi obtida para concentrações entre 4,22×10 -6 -1,35×10 -4 mol L -1 para PRO, 4,00×10 -6 -4,81×10 -5 mol L -1 para 4'-hidroxipropranolol (4'OH PH) e 3,52×10 -6 -4,22×10 -5 mol L -1 para o sulfato de 4'-hidroxipropranolol (4'OH PS). O método descrito é rápido e simples, e pode ser aplicado para determinar os compostos mencionados acima em amostras biológicas. Os resultados obtidos foram verificados por cromatografia líquida de ultra-alta eficiência (ultra HPLC).The electrochemical behavior of propranolol (PRO) and its major metabolites was studied. Voltammetric measurements were made on glassy carbon electrode (GCE). All examined compounds were electrochemically oxidized. In all cases, a separation of oxidation peaks was observed, suggesting the possibility of simultaneous electroanalysis of propranolol and its metabolites. The linearity of the calibration curves was obtained for concentrations between 4.22×10 -6 -1.35×10 -4 mol L -1 for PRO, 4.00×10 -6 -4.81×10 -5 mol L -1 for 4'-hydroxypropranolol (4'OH PH) and 3.52×10 -6 -4.22×10 -5 mol L -1 for 4'-hydroxypropranolol sulfate (4'OH PS). The described method is rapid and simple, and could be applied to determine the above mentioned compounds in biological samples. The obtained results were verified by ultra-high performance liquid chromatography (Ultra HPLC) method.

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Analytical Potentialities of Carbon Nanotube/Silicone Rubber Composite Electrodes: Determination of Propranolol

Cited by 31 publications

References 42 publications

Determination of propranolol and hydrochlorothiazide by batch injection analysis with amperometric detection and capillary electrophoresis with capacitively coupled contactless conductivity detection

Determination of propranolol and hydrochlorothiazide by batch injection analysis with amperometric detection and capillary electrophoresis with capacitively coupled contactless conductivity detection

Bioelectroanalysis of pharmaceutical compounds

Electrochemical behavior of Propranolol and its major metabolites, 4'-hydroxypropranolol and 4'-hydroxypropranolol Sulfate, on glassy carbon electrode

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