Foi estudado o comportamento eletroquímico do propranolol (PRO) e seus principais metabólitos. Medidas voltamétricas foram realizadas em eletrodo de carbono vítreo (GCE). Todos os compostos examinados sofrem oxidação via eletroquímica. Em todos os casos foi observada uma separação dos picos de oxidação, sugerindo a possibilidade de eletroanálise simultânea de propranolol e seus metabólitos. A linearidade das curvas de calibração foi obtida para concentrações entre 4,22×10 -6 -1,35×10 -4 mol L -1 para PRO, 4,00×10 -6 -4,81×10 -5 mol L -1 para 4'-hidroxipropranolol (4'OH PH) e 3,52×10 -6 -4,22×10 -5 mol L -1 para o sulfato de 4'-hidroxipropranolol (4'OH PS). O método descrito é rápido e simples, e pode ser aplicado para determinar os compostos mencionados acima em amostras biológicas. Os resultados obtidos foram verificados por cromatografia líquida de ultra-alta eficiência (ultra HPLC).The electrochemical behavior of propranolol (PRO) and its major metabolites was studied. Voltammetric measurements were made on glassy carbon electrode (GCE). All examined compounds were electrochemically oxidized. In all cases, a separation of oxidation peaks was observed, suggesting the possibility of simultaneous electroanalysis of propranolol and its metabolites. The linearity of the calibration curves was obtained for concentrations between 4.22×10 -6 -1.35×10 -4 mol L -1 for PRO, 4.00×10 -6 -4.81×10 -5 mol L -1 for 4'-hydroxypropranolol (4'OH PH) and 3.52×10 -6 -4.22×10 -5 mol L -1 for 4'-hydroxypropranolol sulfate (4'OH PS). The described method is rapid and simple, and could be applied to determine the above mentioned compounds in biological samples. The obtained results were verified by ultra-high performance liquid chromatography (Ultra HPLC) method.

The new, rapid and sensitive method for the determination of paracetamol (PAR) and its glucuronide (PG) and sulfate (PS) metabolites is proposed. The electrochemical properties of the compounds were examined by cyclic voltammetry (CV) on glassy carbon electrode (GCE). All measurements were carried out in Britton -Robinson buffers (BR) with different pH values over the pH range 1.81 -7.24. The preliminary research indicated that PAR could be determined simultaneously with one of its metabolites. The linearity of calibration curves was obtained for concentrations between 1.65 Â 10 À5 and 1.65 Â 10 À4 M for PAR, 1.53 Â 10 À5 and 1.53 Â 10 À4 M for PG and 2.17 Â 10 À5 and 1.52 Â 10 À4 M for PS.

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