The Preliminary Studies of Electrochemical Behavior of Paracetamol and Its Metabolites on Glassy Carbon Electrode by Voltammetric Methods

Baranowska, Irena; Koper, Marta

doi:10.1002/elan.200804536

Cited by 25 publications

(10 citation statements)

References 15 publications

(14 reference statements)

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“…A linear response was observed over the pH range of 1.2 to 9, beyond which a nonlinear response is observed due to the p K a of the phenolic proton of the acetaminophen being 9.5 35. The linear response of the peak potential as a function of pH ( E p (V)=0.76–0.0485 pH) indicates a gradient of 48.5 mV/pH which is deviated from the typical Nernstian response for a two‐electron, two‐proton process (59 mV/pH) as observed on a glassy carbon electrode 36, yet is in agreement with 45 mV/pH reported by Fanjul‐Bolado et al. 37 using commercially available screen printed electrodes, and also agrees with other previously reported results of 37, 46.5, and 42 mV/pH 35, 38, 39 indicating a complex oxidation mechanism for acetaminophen…”

Section: Resultsmentioning

confidence: 80%

Graphene Electrochemistry: Surfactants Inherent to Graphene Can Dramatically Effect Electrochemical Processes

et al. 2011

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Surfactants are routinely used in the production of graphene and additionally in their solubilisation with the aim of reducing the likelihood of coalescing. We demonstrate that surfactants, which are an inherent property of graphene, are a major contribution to the electrochemical performance. Using well characterised commercially available graphene we demonstrate that the surfactant may be detrimental in electrochemical processes, for example in the electrochemical oxidation of NADH, used prolifically as the basis of over 300 biosensors, and in the electrochemical oxidation of acetaminophen, an analgesic and antipyretic drug which requires routine monitoring in a plethora of areas. The use of control experiments in the form of surfactant modified carbon electrodes is particularly encouraged in de-convoluting the origin of the electrochemical response of graphene modified electrodes.

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Section: Resultsmentioning

confidence: 80%

Graphene Electrochemistry: Surfactants Inherent to Graphene Can Dramatically Effect Electrochemical Processes

et al. 2011

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“…But these techniques are not convenient for routine analysis due to their tedious extraction process. Recently developed electrochemical techniques [24, 25, 26, 27, 28, 29, 30] have received tremendous attention for the detection of PCM and DA in bio fluids, due to their high selectivity, low cost, easy handling and less time consuming nature. Literature review reveals that nano materials with porous morphology having high surface area were conventionally used for electrode material for the detection of bio-molecules as well as drug molecules [31, 32, 33].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical detection of paracetamol and dopamine molecules using nano-particles of cobalt ferrite and manganese ferrite modified with graphite

Kumar

Pramanik

Das

2019

Heliyon

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Some electrodes for efficient detection of paracetamol and dopamine were developed from nano sized material of cobalt ferrite (np-CoFe 2 O 4 ) and manganese ferrite (np-MnFe 2 O 4 ). These oxides were synthesized by combustion method using cobalt nitrate, manganese acetate and ferric nitrate as precursors in the presence of sugar and ethanolamine. The crystallite size, shape and morphology of nano material were characterized by X-ray diffraction pattern (XRD), field emission scanning electron microscopy (FESEM) and energy-dispersive X-ray spectroscopy (EDS) techniques. The crystallite sizes of synthesized nano-particles (nps) were in the range from 10 to 12 nm (calculated using Debye-Scherrer equation) with cubic crystal system. These particles were utilized as electrode modified with graphite for simultaneous detection of paracetamol and dopamine through cyclic voltammetry and Differential pulse voltammetry techniques and was found to be superior to reported literatures. The minimum detection limit of paracetamol and dopamine at CoFe 2 O 4 /GP electrode were 250 nM and 350 nM while at MnFe 2 O 4 /GP electrode it was 300 nM and 400 nM, respectively. Both the electrodes exhibited the linearity range from3 μM to 200 μM & 3 μM–160 μM for paracetamol and 3 μM–180 μM & 5 μM to 200 for dopamine, respectively. Two oxidation peaks of paracetamol and dopamine were well separated in phosphate buffer (pH = 6) in mixture with 100 mVs -1 and 50 mVs -1 scan rate for cyclic voltammetry and Differential pulse voltammetry, respectively. Both the electrodes demonstrated satisfactory results in real samples of paracetamol and dopamine.

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“…The electrochemical responses were measured with the MIP sensor in a 8 mmol/L paracetamol solution, as well as in the equivalent concentrations of the other two counterparts. As shown in Figure 6a, a distinct characteristic oxidation peak of paracetamol at around 485 mV could be observed on the MIP electrode, which was characteristic of oxidation of paracetamol to N ‐acetyl‐ p ‐quinoneimine on solid electrode 11,43. In addition, the current response of MIP sensor toward paracetamol is quite higher than for ascorbic acid and dopamine.…”

Section: Resultsmentioning

confidence: 93%

Paracetamol Sensor Based on Molecular Imprinting by Photosensitive Polymers

Wang¹,

Luo²,

Yi³

et al. 2013

Electroanalysis

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A voltammetric paracetamol sensor based on molecularly imprinted polymeric (MIP) micelles was prepared by direct electrodeposition. The MIP micelles were prepared via macromolecule self‐assembly of an amphiphilic photocrosslinkable copolymer using paracetamol as the template molecule. The resultant molecularly imprinted polymeric micelles swelled with increasing pH, and the disassociation of the micelles occurred at pH above approximately 7.4. A robust MIP film with good solvent resistance was formed on the electrode surface by anodic electrodeposition of the MIP micelles and subsequent photocrosslinking, resulting in the fabrication of a MIP electrochemical sensor for detecting paracetamol. The resultant sensor showed good response and selectivity towards paracetamol. In addition, a wide linear range from 0.01 mmol/L to 8 mmol/L and a low detection limit of 1×10−6 mol/L for paracetamol detection was demonstrated based on this sensor. The MIP sensor also showed good stability and reversibility which was applied to determine paracetamol commercial tablets.

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The Preliminary Studies of Electrochemical Behavior of Paracetamol and Its Metabolites on Glassy Carbon Electrode by Voltammetric Methods

Cited by 25 publications

References 15 publications

Graphene Electrochemistry: Surfactants Inherent to Graphene Can Dramatically Effect Electrochemical Processes

Graphene Electrochemistry: Surfactants Inherent to Graphene Can Dramatically Effect Electrochemical Processes

Electrochemical detection of paracetamol and dopamine molecules using nano-particles of cobalt ferrite and manganese ferrite modified with graphite

Paracetamol Sensor Based on Molecular Imprinting by Photosensitive Polymers

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