Paracetamol Sensor Based on Molecular Imprinting by Photosensitive Polymers

Wang, Xiaohong; Luo, Jing; Yi, Changfeng; Liu, Xiaoya

doi:10.1002/elan.201300050

Cited by 26 publications

(13 citation statements)

References 46 publications

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“…Samples were withdrawn under nitrogen atmosphere from the polymerization mixture after 15 and 45 min, then quenched by cooling with liquid nitrogen (Table 2). One part of each sample was used to determine the MA conversion from 1 H NMR spectrum in CDCl 3 . The other part of the sample was diluted using THF and was analyzed by SEC-MALLS.…”

Section: General Procedures For Set-lrp Of O-nitrobenzylmentioning

confidence: 99%

o -nitrobenzyl acrylate is polymerizable by single electron transfer-living radical polymerization

Soliman

Nouvel

Babin

et al. 2014

J. Polym. Sci. Part A: Polym. Chem.

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Polymers containing o-nitrobenzyl esters are promising for preparation of light sensitive materials. o-Nitrobenzyl methacrylate has already been polymerized by controlled ATRP or RAFT. Unfortunately, the radical polymerization of o-nitrobenzyl acrylate (NBA) was not controlled until now due to inhibition and retardation effects coming from the nitro-aromatic groups. Recent developments in the Single Electron TransferLiving Radical Polymerization (SET-LRP) provide us an access to control this NBA polymerization and living character of this NBA SET-LRP is demonstrated. Effects of CuBr 2 and ligand concentrations, as well as Cu(0) wire length on SET-LRP kinetics are shown presently. A first-order kinetics with respect to the NBA concentration is observed after one induction period. SET-LRP proceeds with a linear evolution of molecular weight and a narrow distribution. High initiation efficiency close to 1 and high chain-end functionality (93%) are reached. Chain extension of poly(o-nitrobenzyl acrylate) is realized with methyl acrylate (MA) to obtain well defined poly(o-nitrobenzyl acrylate)-b-poly(methyl acrylate) (PNBA-b-PMA). Finally, lightsensitive properties of PNBA are checked upon UV irradiation.

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Section: General Procedures For Set-lrp Of O-nitrobenzylmentioning

confidence: 99%

o -nitrobenzyl acrylate is polymerizable by single electron transfer-living radical polymerization

Soliman

Nouvel

Babin

et al. 2014

J. Polym. Sci. Part A: Polym. Chem.

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“…MI functionalization can be obtained before or during the preparation of the composite system. Examples of electrochemical sensors for drugs [81,83,[85][86][87][88], glucose [89], parabens [90], neurotransmitters [82,91], alkaloids [83], pesticides [92] are reported in literature following this approach.…”

Section: Sensors and Biosensors: Label-free Detectionmentioning

confidence: 98%

Molecularly Imprinted Polymeric Micro- and Nano-Particles for the Targeted Delivery of Active Molecules

Gagliardi

Mazzolai

2015

Future Med. Chem.

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Molecular imprinting (MI) represents a strategy to introduce a 'molecular memory' in a polymeric system obtaining materials with specific recognition properties. MI particles can be used as drug delivery systems providing a targeted release and thus reducing the side effects. The introduction of molecular recognition properties on a polymeric drug carrier represents a challenge in the development of targeted delivery systems to increase their efficiency. This review will summarize the limited number of drug delivery MI particles described in the literature along with an overview of potential solutions for a larger exploitation of MI particles as targeted drug delivery carriers. Molecularly imprinted drug carriers can be considered interesting candidates to significantly improve the efficiency of a controlled drug treatment.

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“…In addition, the synthesis of molecularly imprinted polymers is inexpensive, and the storage life of these polymers can be several months or even years without loss of their recognition capacity. In recent years, application to separation and enrichment in environmental [9,10], drugs [11,12] and pesticide [13,14] has attracted increasing attention.…”

Section: Introductionmentioning

confidence: 99%

A Sensitive Electrochemical Sensor Based on Solution Polymerized Molecularly Imprinted Polymers for Procaine Detection

et al. 2016

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A sensitive and selective method for the determination of procaine hydrochloride using molecularly imprinted polymers (MIPs) modified glassy carbon electrodes was developed. The MIPs were prepared by solution polymerization using procaine hydrochloride as the template molecules and acrylic acid (AA) and vinyltriethoxysilane (WD‐20) as the functional monomer and cross‐linking agent, respectively. A film was formed on the surface of the glassy carbon electrodes and later cross‐linked with ethanol as solvent. Next, these electrodes were employed to detect procaine hydrochloride by differential pulse voltammetry (DPV). Under the optimized conditions, good linearity (correlation coefficient of 0.9986) was observed between the oxidation peak current and the concentration of procaine hydrochloride in the range of 4.0×10−8 to 2.4×10−5 M in a pH 7.0 0.04 M phosphate buffer solution, and the detection limit (S/N=3) was 1.02×10−8 M. In addition, the stability and reproducibility of the sensors were satisfactory. Moreover, the concentration of procaine hydrochloride in human blood serum samples was detected, and its recoveries ranged from 97.5 % to 106.4 % with RSD less than 2.15 %. These results suggest that the prepared molecularly imprinted electrochemical sensors can be used for the determination of procaine in clinical studies.

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Paracetamol Sensor Based on Molecular Imprinting by Photosensitive Polymers

Cited by 26 publications

References 46 publications

o -nitrobenzyl acrylate is polymerizable by single electron transfer-living radical polymerization

o -nitrobenzyl acrylate is polymerizable by single electron transfer-living radical polymerization

Molecularly Imprinted Polymeric Micro- and Nano-Particles for the Targeted Delivery of Active Molecules

A Sensitive Electrochemical Sensor Based on Solution Polymerized Molecularly Imprinted Polymers for Procaine Detection

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