Analytical Profiling of Bioactive Constituents from Herbal Products, using Metabolomics - A Review

Satheeshkumar, N.; Nisha, Narayanan; Nirmal, Sonali; Nirmal, Jayabalan; Jain, Gaurav; Spandana, Vudataneni

doi:10.1177/1934578x1200700837

Cited by 12 publications

(12 citation statements)

References 46 publications

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“…Other reviews were generally directed to specific applications where CE was one of the techniques used. CE for the analysis of the constituents of tea ; polyphenolic compounds in fruits and vegetables ; amino acid enantiomers ; antimicrobial food components ; methylxanthines ; optical resolution of flavanones, alkaloids, essential oils, amino acids ; foodomic methodologies ; and analytical profiling of bioactive constituents of herbal products has been reviewed.…”

Section: Previous Reviewsmentioning

confidence: 99%

Capillary electrophoresis of natural products: 2011–2012

et al. 2014

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Bioactive natural products are major sources of lead compounds for drug discovery and pharmaceutical development, therefore, innovative and current separation and characterization techniques are important for these compounds. Here, CE methods applied for the analysis of natural products published during 2011-2012 are reviewed. This is an updated version of an earlier review paper in this journal, which highlighted developments during 2006-2010. The major method developments over the review period centered on derivatization, chiral analysis, modes of detection, stacking or on-line sample concentration, and sample preparation (predominantly using extraction methods). The samples analyzed were herbal products, foods, soil, and biological samples. Developments also occurred in the areas of quality control, toxicology assessment, and enzyme-inhibitor screening. A table that summarizes the areas, source of natural product, nature of the bioactive analyte, CE conditions, LODs, and corresponding reference is provided. A short description on the theory of CE and insights on future activities of CE on natural products are also presented.

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Section: Previous Reviewsmentioning

confidence: 99%

Capillary electrophoresis of natural products: 2011–2012

et al. 2014

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“…Certain cultivars and locations may be more amicable to the accumulation of phytochemicals than others, and these differences must be accounted for in both nutrition research and food processing. Phytoprofiling is now one of the most promising approaches to investigate the bioactive components beneficial to human health and has also been proven to be a valuable analytical tool for the identification of secondary metabolites from medicinal plants, particularly for evidence-based development of new phytotherapeutical agents and nutraceuticals . Because variation in bioactive compounds and human essential nutrients is evident at the metabolite level, the phytoprofiling techniques could be especially useful to measure variation within a plant population or species to determine nutritionally enhanced cultivars …”

Section: Metabolite Profiling Of Phytochemicalsphytoprofilingmentioning

confidence: 99%

“…Phytoprofiling is now one of the most promising approaches to investigate the bioactive components beneficial to human health and has also been proven to be a valuable analytical tool for the identification of secondary metabolites from medicinal plants, particularly for evidence-based development of new phytotherapeutical agents and nutraceuticals. 29 Because variation in bioactive compounds and human essential nutrients is evident at the metabolite level, the phytoprofiling techniques could be especially useful to measure variation within a plant population or species to determine nutritionally enhanced cultivars. 30 Phytoprofiling starts with the analysis of as many as possibly detectable individual components that are present in plants or extracts from individual plants by means of different techniques (liquid chromatography or gas chromatography−MS, NMR, etc.…”

Section: Phytochemicalsphytoprofilingmentioning

confidence: 99%

Toward Personalized Nutrition: Comprehensive Phytoprofiling and Metabotyping

Xie

et al. 2013

J. Proteome Res.

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Nutrition research is increasingly concerned with the complex interactions between multicomponent dietary ingredients and the human metabolic regulatory system. The substantiation of nutritional health benefits is challenged by the intrinsic complexity of macro- and micronutrients and individualized human metabolic responses. Metabonomics, uniquely suited to assess metabolic responses to deficiencies or excesses of nutrients, is used to characterize the metabolic phenotype of individuals integrating genetic polymorphisms, metabolic interactions with commensal and symbiotic partners such as gut microbiota, as well as environmental and behavioral factors including dietary preferences. The two profiling strategies, metabolic phenotyping (metabotyping) and phytochemical profiling (phytoprofiling), greatly facilitate the measurement of these important health determinants and the discovery of new biomarkers associated with nutritional requirements and specific phytochemical interventions. This paper presents an overview of the applications of these two profiling approaches for personalized nutrition research, with a focus on recent advances in the study of the role of phytochemicals in regulating the human or animal metabolic regulatory system.

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“…Medicinal plants treated several diseases throughout the history of mankind and it led to many investigations to identify the metabolites responsible for their curative effects. These bioactive compounds have been the source of many 'modern' pharmaceutical drugs (Satheeshkumar et al, 2012;Wang et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Metabolomic studies of plants are of great importance when one wants to associate bioactivity with the chemical composition of the extract (Castro et al, 2020) and also to identify biomarkers employing metabolic fingerprinting and profiling (Madsen et al, 2010;Takayama et al, 2015). The techniques, 1 H NMR spectroscopy and multivariate data analysis, are complimentary for studying the biochemical composition and metabolic pathways for discovering biomarkers from natural resources such as medicinal plants (Satheeshkumar et al, 2012). Principal component analysis (PCA) and orthogonal projections to latent structures discriminant analysis (OPLS-DA) can classify chemical groups with particular bioactivities and also identify the components responsible for the groupings which could well be used as biomarkers (Castro et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Identification of Anti-HIV Biomarkers of Helichrysum Species by NMR-Based Metabolomic Analysis

Yazdi

Heyman²,

Prinsloo³

et al. 2022

Front. Pharmacol.

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Several species of the Helichrysum genus have been used ethnobotanically to treat conditions that we today know have been caused by viral infections. Since HIV is a modern disease with no ethnobotanical history, we commenced with a study on the anti-HIV activity of several Helichrysum species. Drug discovery of small molecules from natural resources that is based on the integration of chemical and biological activity by means of metabolomical analyses, enables faster and a more cost-effective path to identify active compounds without the need for a long process of bioassay-guided fractionation. This study used metabolomics to identify anti-HIV compounds as biomarkers from 57 Helichrysum species in a combined study of the chemical and biological data of two previous studies. In the OPLS-DA and hierarchical cluster analyses, anti-HIV activity data was included as a secondary observation, which assisted in the correlation of the phytochemical composition and biological activity of the samples. Clear grouping revealed similarity in chemical composition and bioactivity of the samples. Based on the biological activity of polar extracts, there was a distinct phytochemical difference between active and non-active groups of extracts. This NMR-based metabolomic investigation showed that the chlorogenic acids, compounds with cinnamoyl functional groups, and quinic acid were the most prominent compounds in the Helichrysum species with anti-HIV activity. This study further revealed that the chlorogenic acid type compounds and quinic acid are biomarkers for anti-HIV activity.

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Analytical Profiling of Bioactive Constituents from Herbal Products, using Metabolomics - A Review

Cited by 12 publications

References 46 publications

Capillary electrophoresis of natural products: 2011–2012

Capillary electrophoresis of natural products: 2011–2012

Toward Personalized Nutrition: Comprehensive Phytoprofiling and Metabotyping

Identification of Anti-HIV Biomarkers of Helichrysum Species by NMR-Based Metabolomic Analysis

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