Analytical Reagents used in Chemical and Spectrophotometric Analysis

Sravani, K.; Masthanamma, Shaik; Prasanna, V. Lakshmi; Sowmya, Dantu Krishna; Tanuja, A.

doi:10.5958/0974-360x.2015.00020.7

***

2015

DOI: 10.5958/0974-360x.2015.00020.7

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Analytical Reagents used in Chemical and Spectrophotometric Analysis

K. Sravani¹,

Shaik Masthanamma²,

V. Lakshmi Prasanna³

et al.

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Cited by 3 publications

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A Comprehensive Review of Drugs Determined by Spectrophotometry using Vanillin as a Chromogenic Reagent in the Past Decade

Naraparaju,

Barla,

Chaganti

et al. 2024

CPA

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Many analytical techniques have been used in quality control, such as spectrophotometry, spectrofluorimetry, HPLC, and other hyphenated techniques. Among them, spectrophotometry is considered to be one of the most commonly used simple techniques. Drugs that lack chromogenic groups can be readily determined by using the chromogenic reagents, which react with the functional groups present in the drugs and produce a chromogenic group that can be detected in the visible region using a spectrophotometer. Chromogenic reagents play a vital role in the estimation of such types of drugs. Vanillin is one of the chromogenic reagents that possess a carbonyl group that reacts with the drugs that possess amine moiety and results in the formation of Schiff’s base, which is a yellow-colored compound that can be detected by spectrophotometry. The present review gives insights into the reaction conditions and applications of the drugs that are estimated by using vanillin as a chromogenic label.

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A Comprehensive Review of Drugs Determined by Spectrophotometry using Vanillin as a Chromogenic Reagent in the Past Decade

Naraparaju,

Barla,

Chaganti

et al. 2024

CPA

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Formulation and Optimization of Bicalutamide Tablets by using Factorial Design

Roy,

Singh,

Kalra

2024

RJPT

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The robustness of pharmaceutical dosage forms entails optimizing both the formulation and the level of excipients to obtain the desired quality features. To optimize the formulation in this investigation, a factorial design approach was adopted. For enhancing the dissolution of a Biopharmaceutics Classification (BCS) Class II drug, a two-level four-factor partial factorial design was advocated. Factorial design is a method for systematically determining the relationship between independent process factors and their effect on the response variable. Partial factorial designs were applied in this research work. The particle size distribution of Lactose Anhydrous is used as a dependent variable and Sodium Starch Glycolate (Primojel/Type A) and Magnesium Stearate, Pregelatinised starch (Lycatab)/Anhydrous Lactose/Lactose Anhydrous (Super Tab 21 AN) ratio and the Particle size distribution were used as independent variables for optimization. Response parameters for the final Bicalutamide Tablets 50mg were the percentage of Bicalutamide Tablets 50mg dissolved at thirty minutes. The factorial design models were validated for accurate prediction of response characteristics and used to identify the optimum formulation. Response parameters for final Bicalutamide Tablets 50mg were the percentage of Bicalutamide Tablets 50mg dissolved at thirty minutes. The data were analyzedand response surfaces were generated for tablet percentage of dissolution and content uniformity.

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A Review UV Method Development and Validation

P. Shinde,

D. Rajmane

2023

AJPA

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Ultraviolet spectroscopy is one important and advanced analytical instrument in the Pharmaceutical industry and used for the last 35 years. The method of analysis is based on measuring the absorption of monochromatic light by colorless compounds in the near-ultraviolet path of the spectrum (200-400nm). The pharmaceutical analysis comprises the procedures necessary to determine such compounds' “identity, strength, quality, and purity”. It also includes the analysis of raw materials and intermediates during the manufacturing process of drugs. The fundamental principle of operation of a spectrophotometer covering the UV region consists that light of a definite interval of wavelength passes through a cell with solvent and falls onto the photoelectric cell that transforms the radiant energy into electrical energy measured by a galvanometer. Ultraviolet-visible spectroscopy is used to obtain the absorbance spectra of a compound in solution or as a solid.

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Analytical Reagents used in Chemical and Spectrophotometric Analysis

Cited by 3 publications

References 0 publications

A Comprehensive Review of Drugs Determined by Spectrophotometry using Vanillin as a Chromogenic Reagent in the Past Decade

A Comprehensive Review of Drugs Determined by Spectrophotometry using Vanillin as a Chromogenic Reagent in the Past Decade

Formulation and Optimization of Bicalutamide Tablets by using Factorial Design

A Review UV Method Development and Validation

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