Analytical tools for determination of new oral antidiabetic drugs, glitazones, gliptins, gliflozins and glinides, in bulk materials, pharmaceuticals and biological samples

Gumieniczek, Anna; Berecka, Anna

doi:10.1515/chem-2016-0023

Cited by 18 publications

(6 citation statements)

References 91 publications

(6 reference statements)

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“…Based on reports published by International Diabetes Federation, the total number of those suffering from diabetes is growing every year. For instance, according to statistic predictions, type 2 diabetes, currently affecting about 8% of adult population, would spread in such a pace that by 2030, more than 40 million cases can be found throughout the world. − Metformin ( N , N -dimethylbiguanide) is a popular glucose-lowering agent that helps type 2 diabetic patients in better insulin performance. − …”

Section: Introductionmentioning

confidence: 99%

A Facile Colorimetric and Spectrophotometric Method for Sensitive Determination of Metformin in Human Serum Based on Citrate-Capped Gold Nanoparticles: Central Composite Design Optimization

Shahbazi

Zare‐Dorabei

2019

ACS Omega

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For the determination of Metformin in human serum, a facile colorimetric and spectrophotometric sensor was designed based on citrate-capped gold nanoparticles (citrate-GNPs). In this probe, the addition of Metformin to GNP solution generates a naked-eye color change resulting from the aggregation of GNPs. Study of this color conversion and quantity analysis of analyte is operated by spectrophotometric instruments. The three factors pH, time, and GNP ratio were selected to examine their effects on sensing results and their values optimization. The optimization of parameters was done by means of central composite design and one-at-a-time methods. The sensing results proved the highly selective and sensitive performance of the sensor for Metformin in a linear range of 6.25–133.3 ppm with a detection limit of 1.79 ppm. The relative standard deviation (RSD) of the reported method is 2.53%.

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Section: Introductionmentioning

confidence: 99%

A Facile Colorimetric and Spectrophotometric Method for Sensitive Determination of Metformin in Human Serum Based on Citrate-Capped Gold Nanoparticles: Central Composite Design Optimization

Shahbazi

Zare‐Dorabei

2019

ACS Omega

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“…The statistically significant value for intravenous and oral administration of (+)-terbutaline was slightly higher than for (−)-terbutaline [63]. pharmacological studies, pharmacokinetic studies, and therapeutic drug monitoring [76][77][78]. Recently, the enantioseparation of chiral pharmaceuticals in the environmental matrices becomes more important.…”

Section: Stereoselective Pharmacokinetics Of β 2 -Agonistsmentioning

confidence: 99%

Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

2020

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Abstractβ2-Agonists (β2-adrenergic agonists, bronchodilatants, and sympathomimetic drugs) are a group of drugs that are mainly used in asthma and obstructive pulmonary diseases. In practice, the substances used to contain one or more stereogenic centers in their structure and their enantiomers exhibit different pharmacological properties. In terms of bronchodilatory activity, (R)-enantiomers showed higher activity. The investigation of stereoselectivity in action and disposition of chiral drugs together with the preparation of pure enantiomer drugs calls for efficient stereoselective analytical methods. The overview focuses on the stereoselectivity in pharmacodynamics and pharmacokinetics of β2-agonists and summarizes the stereoselective analytical methods for the enantioseparation of racemic beta-agonists (HPLC, LC-MS, GC, TLC, CE). Some methods of the stereoselective synthesis for β2-agonists preparation are also presented.

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“…Such sodium-glucose cotransporters are responsible for reabsorbing glucose into the kidney. [2,3] An extensive literature survey has revealed that there are few methods that are reported for estimation of SAXA and DAPA individually or in combination with other drugs by UV method, [4][5][6][7] reverse phase high performance liquid chromatographic (RP-HPLC) method, [8][9][10][11][12][13][14][15][16] tandem mass spectrometry method, [17] or LC-MS. [18,19] Hence, we propose to develop methods that are more reliable, sensitive, and simple for simultaneous estimation of SAXA and DAPA in bulk as well as a pharmaceutical formulation. In the present work, we developed and validated the UV method and RP-HPLC method for the simultaneous estimation of SAXA hydrochloride and DAPA in bulk drug and its formulation as per ICH guidelines Q2(R1).…”

Section: Introductionmentioning

confidence: 99%

Development and Validation RP-HPLC Method for Simultaneous Estimation of Dapagliflozin and Saxagliptin in Bulk and Pharmaceutical Dosage Form

Nizamuddin¹,

Raju

2022

APJHS

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A simple, precise, sensitive, and rapid reverse phase high performance liquid chromatographic method was developed and validated for simultaneous estimation of Dapagliflozin (DAPA) and Saxagliptin (SAXA) in bulk as well as in tablet formulation according to the ICH guidelines. The chromatographic phase consisted by phosphate buffer: Acetonitrile, pH 4.0 adjusted by glacial acetic acid. The flow rate was adjusted to 0.8 ml/min and UV detection was carried out at 220 nm. Retention time was found to be 2.144 and 3.156 min; respectively. The detector was showed that linear responses over the concentration range 10–24 μg/ml for SAXA and 12–40 μg/ml for DAPA a good correlation coefficient of 0.999. This proposed method is highly sensitive, precise, and accurate which reduces cost of analysis; hence, recommended for routine quality analysis in laboratories.

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Analytical tools for determination of new oral antidiabetic drugs, glitazones, gliptins, gliflozins and glinides, in bulk materials, pharmaceuticals and biological samples

Abstract: Abstract:The review presents analytical methods for determination of new oral drugs for the treatment of type 2 diabetes mellitus (T2DM

Cited by 18 publications

References 91 publications

A Facile Colorimetric and Spectrophotometric Method for Sensitive Determination of Metformin in Human Serum Based on Citrate-Capped Gold Nanoparticles: Central Composite Design Optimization

A Facile Colorimetric and Spectrophotometric Method for Sensitive Determination of Metformin in Human Serum Based on Citrate-Capped Gold Nanoparticles: Central Composite Design Optimization

Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

Development and Validation RP-HPLC Method for Simultaneous Estimation of Dapagliflozin and Saxagliptin in Bulk and Pharmaceutical Dosage Form

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