Analyzer scan modes for hybrid mass spectrometers

Glish, Gary L.; McLuckey, Scott A.

doi:10.1002/oms.1210240706

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…EIEo=65/128=0.508 (7) The sequence leading to the artefact would, however, require the second electric sector to be set at 0.719, as indicated in Eqn (5). Thus the interference from the doubly charged ion would not appear in the spectrum.…”

Section: Artefacts Occurring In Forward-geometry (Eb) Instrumentsmentioning

confidence: 99%

“…M2++[M -HC1I2+' E/Eo= (92/2)/(128/2) =0.719( 5 ) M+'+[M -C1]"EIEo=93/128=0.726 (6) The fragmentation of the doubly charged ions could thus occur in the electric sector, in such a way as to result in the transmission of the [M -HC1I2+ fragment. While this type of analysis is not very common, it demonstrates the fact that an artefact peak is not necessarily the result of a fragmentation within a field-Representation of B/E and B/E,E2 scans for EB and EBE geometry instruments, respectively.…”

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confidence: 99%

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Graphical method for artefact peak interpretation, and methods for their rejection, using double and triple sector magnetic mass spectrometers

Mouget

Bertrand

1995

Rapid Comm Mass Spectrometry

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The problem of artefact peaks, in spectra obtained from various tandem mass spectrometric scans on instruments of both forward and reverse geometry, is examined. The filtering conditions imposed by additional analyzers are investigated, in order to evaluate the potential of several different triple sector geometries to reduce specific interferences. No previous evaluation of the rejection ability for artefacts of different origins has been presented with respect to the various geometries. In order to gain a better insight into the origin of various artefacts, and to more easily explain their occurrence in certain geometries, a new graphical representation was developed in order to take into account the effects of three analyzer fields. This approach allows different linked scans to be projected within a cube, while also qualitatively proposing an explanation for the presence or absence of artefact peaks. New scans can also be conceived by means of this method, as is the case with a new selected mass ion kinetic energy (SMIKE) scan, which allows artefacts present in MIKE scans performed using reverse geometry instruments to be determined.While the advantages of double focusing mass spectrometers over single sector instruments have long been established, differences of opinion still persist on the versatility of the most common geometries encountered in multisector instruments with respect to tandem mass spectrometry (MSIMS).' In addition to the differences in performance and scanning abilities, discrepancies observed in spectra obtained using spectrometers of different analyzer arrangements have led to this study, in which the discriminating properties of several geometries are compared. The forward geometry, in which the electric sector (E) precedes the magnetic sector (B), offers the possibility of performing linked scans to sample the fragment ions formed in the first field-free region (FF1). Normal metastable transitions are observed in mass spectra obtained by magnet scans using E B geometry spectrometers. Reverse geometry instruments (BE) not only allow FF1 reactions to be sampled for fragments, but also reactions occurring in the second field-free region (FF2) located between the two Normal metastable transitions are not observed in mass spectra obtained by magnet scans of instruments of BE geometry.Depending o n the geometry of the instrument, different scanning techniques are available in order to analyze the fragment ions formed in the field-free regions. Several of these techniques are commonly referred to as 'linked-scanning', as they involve scanning two or more fields with a predetermined functional relationship between them.4-7 Linked scans involving E and B have become an invaluable tool for studying ion chemistry and performing mixture analysis.' A double focusing mass spectrometer thus presents the user with an instrument capable of measuring the mass of an ion with high accuracy, and of suggesting possible fragmentation sequences for a selected ion.The basis for the equations determining a linke...

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Section: Artefacts Occurring In Forward-geometry (Eb) Instrumentsmentioning

confidence: 99%

mentioning

confidence: 99%

Graphical method for artefact peak interpretation, and methods for their rejection, using double and triple sector magnetic mass spectrometers

Mouget

Bertrand

1995

Rapid Comm Mass Spectrometry

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“…The many scan modes accessible to Q X hybrid instruments have been discussed by Glish and McLuckey (114). who make a persuasive case that tandem-inspace instruments of this type should be particularly useful for MS/MS work.…”

Section: Electric Sector (Elmentioning

confidence: 99%

Linked‐scan techniques for MS/MS using tandem‐in‐space instruments

Boyd

1994

Mass Spectrometry Reviews

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Witness this army, of such mass and charge" Shakespeare, W.; Hamlet, 1601, Act IV, Scene 4, line 47. CCC 0277-7037/95/05/60359-52 LINKED-SCAN TECHNIQUES FOR MS/MS FIGURE 2. One-dimensional spectra for ions formed from decane, cxtracted from the complete two-dimensional MSiMS domain shown in Fig. I . Such one-dimensional spectra could be obtained by appropriate single scans, without obtaining all the information exhibited in thc full MS/MS domain. Full circles denote ions whose m i z values are fixed by the conditions of the experiment. and open circles denote ions whose m l i values are to be obtained from the appropriate one-dimensional scan. Reproduced from Ref. (2), by permission.appropriate kinds, without generating the complete MS/MS domain. This review is concerned with the experimental methods for generating such scans, using some common mass spectrometer designs. A more fundamental comment on maps like Fig. 1 concerns the significance of the observation. or not, of any particular reaction. Any such observation strictly refers only to the reaction timescale and other conditions pertinent to the particular apparatus in use. For example, the fact that the ion at m/z 43 was observed ( Fig. 2) to arise from the ion at m / z 85, as well as from the ion at m/z 71, does not necessarily imply that the direct (single-step) reaction (m/z 85+ 43) does occur. The only valid conclusion is that some ions of m/z 85, extracted from the ion source, can fragment to yield m/z 43, but whether or not all such events involve an intermediate at m/z 7 1 cannot be determined from these experiments alone. It is also important to note that the great majority of MS/MS experiments investigate fragmentation reactions (m, < m, , where m, is the molecular mass of species X ) . However, at the lower collision energies characteristic of quadrupole instruments, it is also possible to induce chemical reactions between the reactant ion and a suitable collision gas, such that m, > m,. LINKED-SCAN TECHNIOUES FOR MS/MSFIGURE 3. Schematic representations of the action of (a) magnetic and (b) electric sector fields. In each case. 0 is the subject slit (length dimension perpcndicular 10 the plane of the paper. closeable in the plane). The angular spreads of the ion beam in the plane (which is perpendicular to the magnetic field direction, but contains the electric field lines) are a,,, and a,, respectively. (a) F,,? F , , F2, and F3 are the respective direction focus points for ions of mass m, and velocity u , [Eq. (28)]. mass (m, + 8m) and velocity u , , mass m R , and velocity [Eq. (28)] ( u , + Su), and mass (m,< + Sm) and velocity ( u , + 6u). Thus. the differences between F,, and F,. and between Fz and F2, represent the effective mass dispersion of the magnet. The differences between F,, and F2, and between F, and F; reflect the velocity dispersion. (b) F,, is the direction focus point for ions with any combination of m and u consistent with a kinetic energy ke) [Eq. (30)]. and F, is thc direction focus point [Eq. (30)] for ions with a kinetic...

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The Precursor scan. A new type of experiment in neutralization–reionization mass spectrometry

Tureček

1993

Org. Mass Spectrom.

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A new scan technique utilizing the tandem quadrupole acceleration-deceleration mass spectrometer is described The technique is based on combined monitoring of neutral and ion precursors that fragment following collisional electron transfer to give rise to a selected low-mass neutral species and its ion, respectively. P O is found to be a stable neutral species formed by dissociations of a variety of oxidized phosphorus compounds, such as di-and trialkyl phosphites, phosphates and phosphonic esters. These compounds can be selectively monitored through PO' precursor scans in multi-component mixtures. Interferences from isobaric neutral species, 3sCIC, CH,S, CH, 30SiH,', and their precursors are discussed. Neutralization-reionization spectra of phosphoruscontaining radicals, PO', CH,OPH', CH,OPOH, 'P(OCH,), and (CH,O),PO', are also reported. co+' 15.16 SO+. 17.18 CS + . , I 9 HCN+' 20.21

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Analyzer scan modes for hybrid mass spectrometers

Cited by 4 publications

References 28 publications

Graphical method for artefact peak interpretation, and methods for their rejection, using double and triple sector magnetic mass spectrometers

Graphical method for artefact peak interpretation, and methods for their rejection, using double and triple sector magnetic mass spectrometers

Linked‐scan techniques for MS/MS using tandem‐in‐space instruments

The Precursor scan. A new type of experiment in neutralization–reionization mass spectrometry

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