Analyzing multiple risk factors in patients with sarcomas. A case-control study

Nabi, Shahzaib; Kahlon, Pushpinderdeep; Kuriakose, Philip

doi:10.4103/0019-509x.176752

Cited by 3 publications

(11 citation statements)

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“…On the other hand, an Italian hospital-based case-control study detected no effect of smoking on soft tissue sarcoma [22]. In 2015, smoking was reported as a potential risk factor for sarcoma with an OR of 2.67 [23]. (Table 7).…”

Section: Discussionmentioning

confidence: 99%

“…A large number of carcinogens in cigarette smoke have been implicated as contributors to oncogenesis in various types of cancer [1][2][3][4][5][6][7]. However, there have only been a few previous reports about the association between smoking and sarcoma development [22][23][24][25][26]42]. Recent genomic studies have expanded our knowledge regarding the basis of carcinogenesis, including sarcoma; however, gene abnormalities, such as fusion genes or driver mutations, in most types of sarcoma remain unclear [43][44][45][46][47][48][49][50].…”

Section: Discussionmentioning

confidence: 99%

“…Some sarcoma patients had a family history of cancer [23,54,55]. McDu e et al stated that 37% (133/357) of soft tissue sarcoma patients had a rst-degree relative with a history of cancer [54].…”

Section: Discussionmentioning

confidence: 99%

“…McDu e et al stated that 37% (133/357) of soft tissue sarcoma patients had a rst-degree relative with a history of cancer [54]. Nabi et al reported that 35% (147/425) sarcoma patients had a rst-degree relative with a history of cancer [23]. In our study, 30% (311/1046) of the soft tissue sarcoma patients had a rst-degree relative with a history of cancer, which was close to the rate of a previous report ( Table 9).…”

Section: Discussionmentioning

confidence: 99%

“…However, there have been few studies on the lifestyle habits or lifestyle-related diseases associated with sarcomas [21][22][23][24][25][26][27][28]. There are more than 50 distinct histologic subtypes of sarcoma in 2013 WHO (World Health Organization) classi cation [28], and many of the subtypes can occur at any age, and are not limited to a speci c location in the body, which was one of the differences from other cancers.…”

Section: Introductionmentioning

confidence: 99%

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Smoking and Family Cancer History Are Associated With Sarcomas in A Japanese Population Study

Araki

Yamamoto

Tanzawa

et al. 2020

Preprint

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Background: Sarcoma is a rare cancer, and it is also the cause of the development of various kinds of sarcomas, such as gene abnormalities, which has recently becoming evident due to advances of genetic testing. The approach to solve the origin of diseases is essential to elucidate both the external environmental factors and the internal genetic factors. However, the lifestyle habits, lifestyle-related diseases, personal and family cancer history of sarcoma patients remain unclear.Methods: A total of 1320 sarcoma patients were enrolled in this study. A questionnaire on lifestyle habits, life-style diseases, and the patient’s personal and family cancer history was completed at presentation. A total of 1320 controls were selected by propensity score matching for age and gender. Smoking, drinking, obesity, hypertension, dyslipidemia and diabetes mellitus were compared. In addition, we investigated the incidence of a personal and family cancer history in sarcoma patients. Results: A smoking habit was the only independent risk factor for high-grade soft tissue sarcoma development in adults ≥20 years old (n=952), excluding low-grade and intermediate malignant soft tissue tumors (Odds ratio [OR], 2.45; 95% confidence interval [CI] 1.88-3.20, p<0.001). The ORs of high-grade liposarcoma and undifferentiated pleomorphic sarcoma (UPS) were 2.56 and 3.00, respectively. Eight percent of sarcoma patients had a personal history of another cancer. Thirty percent of soft tissue sarcoma patients had a family history of cancer in a first-degree relatives (malignant peripheral nerve sheath tumor, 52%; leiomyosarcoma, 46%). Conclusions: We confirmed that a smoking habit were associated with the development of high-grade soft tissue sarcomas. A family history of cancer might be associated with certain soft tissue sarcomas, but a further investigation will be necessary.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Smoking and Family Cancer History Are Associated With Sarcomas in A Japanese Population Study

Araki

Yamamoto

Tanzawa

et al. 2020

Preprint

View full text Add to dashboard Cite

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Family cancer history and smoking habit associated with sarcoma in a Japanese population study

Araki

Yamamoto

Tanzawa

et al. 2022

Sci Rep

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Sarcoma is a rare cancer, and little is known about the etiology, lifestyle epidemiology, and actual circumstances of treatment in hospitals in Japan. Understanding these issues is essential for the effective prevention and treatment of sarcoma. We therefore investigated the incidence of a personal and family cancer history in a total of 1320 sarcoma patients at the National Cancer Center Hospital. In addition, obesity, hypertension, dyslipidemia, diabetes mellitus, drinking, smoking, age and sex were compared in a descriptive study of 1159 of these sarcoma patients who were ≥ 20 years of age, and 7738 controls derived from the National Health and Nutrition Examination Survey in Japan. A total of 8% of sarcoma patients had a personal history of another cancer, and 30% of soft tissue sarcoma patients had a family cancer history in a first-degree relative (malignant peripheral nerve sheath tumor, 52%; leiomyosarcoma, 46%). A smoking habit was associated with the development of sarcoma (odds ratio [OR], 2.05; 95% confidence interval, 1.78–2.37; p < 0.01). According to the histology, the ORs for undifferentiated pleomorphic sarcoma (UPS) of bone, UPS of soft tissue, and liposarcoma were 5.71, 3.04, and 2.92, respectively. A family cancer history may be associated with certain soft tissue sarcomas, and a smoking habit was significantly associated with the development of sarcomas; however, further studies are necessary.

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Association between microRNA 671 polymorphisms and the susceptibility to soft tissue sarcomas in a Chinese population

Zhang

Huang

et al. 2022

Front. Oncol.

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This study evaluated the association between the microRNA (miRNA) gene polymorphisms and the susceptibility to soft tissue sarcomas (STSs). In this case–control study, DNA was extracted from leukocytes in peripheral blood, which was collected from 169 STSs patients and 170 healthy controls. Three SNPs for miR-210, five SNPs for miR-206, two SNPs for miR-485, two SNPs for miR-34b, two SNPs for miR-671, and three SNPs for miR-381 were investigated and genotyped using a Sequenom Mass ARRAY matrix-assisted laser desorption/ionization-time of flight mass spectrometry platform. Unconditional logistic regression analysis was used to analyze the association between miRNA gene polymorphisms and the susceptibility to STSs. The results showed that miR-671 rs1870238 GC + CC (OR = 1.963, 95% CI = 1.258–3.064, P = 0.003) and miR-671 rs2446065 CG + GG (OR =1.838, 95% CI = 1.178–2.868, P = 0.007) may be genetic risk factors for STSs after adjustment for age and smoking. Therefore, this study suggests that individuals carrying the GC + CC genotype for miR-671 rs1870238 or the CG + GG genotype for miR-671 rs2446065 are susceptible to STSs.

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Analyzing multiple risk factors in patients with sarcomas. A case-control study

Abstract: Smoking and alcohol are potential risk factors for sarcomas. In addition, a history of cancer in the first-degree relative is also a potential risk factor. Patients with sarcomas are likely to have a history of another malignancy when compared with controls.

Cited by 3 publications

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Smoking and Family Cancer History Are Associated With Sarcomas in A Japanese Population Study

Smoking and Family Cancer History Are Associated With Sarcomas in A Japanese Population Study

Family cancer history and smoking habit associated with sarcoma in a Japanese population study

Association between microRNA 671 polymorphisms and the susceptibility to soft tissue sarcomas in a Chinese population

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