Analyzing the effectiveness of using branchial NKA activity as a biomarker for assessing waterborne copper toxicity in tilapia (Oreochromis mossambicus): A damage-based modeling approach

Wu, Su‐Mei; Tsai, Jeng‐Wei; Tzeng, Wen-Nan; Chen, Wei Yu; Shih, Wan-Yu

doi:10.1016/j.aquatox.2015.03.016

Cited by 10 publications

(2 citation statements)

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“…The general unified threshold model of survival (GUTS) is an often-used mechanistic TK-TD model that can successfully simulate the bioaccumulation of pollutants and its correlation to survival over time for aquatic organisms. , The GUTS model was separated into two parts, which included the TK and TD processes, to estimate the specific parameters describing the TK process (including uptake and elimination) and the TD process with survival as end point. Since metal toxicity may be more closely linked with the metal subcellular distribution pools rather than overall metal bioaccumulation, the link between metal bioaccumulation in different subcellular pools and metal toxicity may be more realistic in the TK modeling. Therefore, the TK model based on subcellular distribution allows for estimating parameters that describe uptake, subcellular distribution, and elimination of metal for subcellular fractions.…”

Section: Introductionmentioning

confidence: 99%

Role of Toxicokinetic and Toxicodynamic Parameters in Explaining the Sensitivity of Zebrafish Larvae to Four Metals

Yang

Feng

Gao

et al. 2021

Environ. Sci. Technol.

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Given the persistence and toxic potencies of metal contaminants in ecosystems, animals, and human beings, they are considered to be hazardous global pollutants. While the lethality of metal toxicities (e.g., LC50) can significantly vary, even within the same species, the underlying mechanisms are less well-understood. In this study, we developed a subcellular two-compartment toxicokinetic-toxicodynamic (TK-TD) model for zebrafish larvae when exposed to four metals (cadmium, lead, copper, and zinc) to reveal whether differences in metal toxicity (LC50 values) were dominated by the TK or TD processes. Results showed that the subcellular TK and TD parameters of the four metals were significantly different, and the bioconcentration factor (BCF) value of copper was higher than those of the other metals. We also found that the TD parameter internal threshold concentration (C IT) was significantly positively correlated to the LC50 values (R 2 = 0.7), suggesting a dominant role of TD processes in metal toxicity. Furthermore, the combined parameter C IT /BCF for a metal-sensitive fraction (BCFMSF), which linked exposure to effects through the TK-TD approach, explained up to 89% of the variation in toxicity to the four metals. The present study suggests that the observed variation in toxicity of these four metals was mainly determined by TD processes but that TK processes should not be ignored, especially for copper.

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Section: Introductionmentioning

confidence: 99%

Role of Toxicokinetic and Toxicodynamic Parameters in Explaining the Sensitivity of Zebrafish Larvae to Four Metals

Yang

Feng

Gao

et al. 2021

Environ. Sci. Technol.

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“…Effluent discharged from WWTPs can be a source of thermal pollution in effluent-receiving environments (Environment Canada, 2001), increasing the temperature by as much as 5–9°C (personal observations downstream of Woodward Avenue WWTP, Hamilton, ON, Canada, 2018). Previous studies have demonstrated links between the effects of temperature on the toxicity of chemicals using a variety of fish species and chemicals (Nussey et al, 1996). Zebrafish ( Danio rerio ) exposed to cadmium at temperatures ranging from 12 to 34°C demonstrated increasing cadmium-tissue accumulation and toxicity, measured by mortality, with increasing temperature (Vergauwen et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Multiple Stressors in the Environment: The Effects of Exposure to an Antidepressant (Venlafaxine) and Increased Temperature on Zebrafish Metabolism

et al. 2019

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Aquatic organisms are continuously exposed to multiple environmental stressors working cumulatively to alter ecosystems. Wastewater-dominated environments are often riddled by a myriad of stressors, such as chemical and thermal stressors. The objective of this study was to examine the effects of an environmentally relevant concentration of a commonly prescribed antidepressant, venlafaxine (VFX) [1.0 μg/L], in addition to a 5°C increase in water temperature on zebrafish metabolism. Fish were chronically exposed (21 days) to one of four conditions: (i) 0 μg/L VFX at 27°C; (ii) 1.0 μg/L VFX at 27°C; (iii) 0 μg/L VFX at 32°C; (iv) 1.0 μg/L VFX at 32°C. Following exposure, whole-body metabolism was assessed by routine metabolic rate (RMR) measurements, whereas tissue-specific metabolism was assessed by measuring the activities of major metabolic enzymes in addition to glucose levels in muscle. RMR was significantly higher in the multi-stressed group relative to Control. The combination of both stressors resulted in elevated pyruvate kinase activity and glucose levels, while lipid metabolism was depressed, as measured by 3-hydroxyacyl CoA dehydrogenase activity. Citrate synthase activity increased with the onset of temperature, but only in the group treatment without VFX. Catalase activity was also elevated with the onset of the temperature stressor, however, that was not the case for the multi-stressed group, potentially indicating a deleterious effect of VFX on the anti-oxidant defense mechanism. The results of this study highlight the importance of multiple-stressor research, as it able to further bridge the gap between field and laboratory studies, as well as have the potential of yielding surprising results that may have not been predicted using a conventional single-stressor approach.

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The Development of Quantitative AOPs

Schultz

Watanabe

2018

A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment

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Analyzing the effectiveness of using branchial NKA activity as a biomarker for assessing waterborne copper toxicity in tilapia (Oreochromis mossambicus): A damage-based modeling approach

Cited by 10 publications

References 50 publications

Role of Toxicokinetic and Toxicodynamic Parameters in Explaining the Sensitivity of Zebrafish Larvae to Four Metals

Role of Toxicokinetic and Toxicodynamic Parameters in Explaining the Sensitivity of Zebrafish Larvae to Four Metals

Multiple Stressors in the Environment: The Effects of Exposure to an Antidepressant (Venlafaxine) and Increased Temperature on Zebrafish Metabolism

The Development of Quantitative AOPs

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