Analyzing the Genomes of Coxsackievirus A16 and Enterovirus 71 in Relation to Hand, Foot and Mouth Disease(HFMD) Using Apriori Algorithm, Decision Tree and Support Vector Machine (SVM)

Abstract

Abstract. Hand, foot and mouth disease (HFMD), caused by highly infectious intestinal viruses of either coxsackievirus A16 (CVA16) or enterovirus 71 (EV71), is a common children syndrome featured by mild fever, spots and bumps that blister the skin of hands, oral cavity in mouth, feet and sometimes to the extent of buttocks and genitalia. Though CVA16 and EV71 both cause the HFMD, the intensity of each symptom is obviously different. Normal cases are HFMD by CVA16, which are typically characterized by mild symptoms usually treated in 6−8 days. Conversely, HFMD by EV71 results severe neural disorders and various influenza complications that even cause death. Currently, no vaccine is available to protect individuals from infection by the viruses that cause HFMD. In order to investigate why these two viruses have too much differences in degree of symptoms and compare the inner relationships to the medical effects, we analyzed the genomes of CVA16 and EV71 by using apriori algorithm, decision tree and support vector machine (SVM). Therefore, by comparing the genomes of each virus, we found out better results for analyzing the relationship between the two and state the potential of developing medical remedy in DNA point of view.