Analyzing the synergistic adverse effects of BPA and its substitute, BHPF, on ulcerative colitis through comparative metabolomics

Yin, Feiying; Huang, Xue; Lin, Xiao; Chan, Ting‐Fung; Lai, Keng Po; Li, Rong

doi:10.1016/j.chemosphere.2021.132160

Cited by 16 publications

(6 citation statements)

References 40 publications

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“…Furthermore, differential acid metabolites were selected with P < 0.05, and shown in Table S1 . TNBS treatment upregulated the intestinal production of arachidonic acid, citric acid, corchorifatty acid D, formiminoglutamic acid, galactonic acid, ganoderic acid F, hexadecanedioic acid, and hippuric acid, which resulted in the proinflammatory response, pain, and fever, [ 47 ] and downregulated the production of docosapentaenoic acid, dodecanedioic acid, ganoderic acid H, ganoderic acid K, and gentisic acid, which could reduce intestinal inflammatory disorder. [ 48 ] After treatment with GPM, EcN and GPM-EcN, the cluster moved close to the normal group, and rat treated with GPM-EcN and free EcN even had a more similar dot distribution with normal rat in comparison to that of GPM, indicating GPM-EcN and free EcN recovered acid metabolites to normal level.…”

Section: Resultsmentioning

confidence: 99%

Intracellular hydrogelation of macrophage conjugated probiotics for hitchhiking delivery and combined treatment of colitis

Wang

Chen

et al. 2023

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

Intracellular hydrogelation of macrophage conjugated probiotics for hitchhiking delivery and combined treatment of colitis

Wang

Chen

et al. 2023

Materials Today Bio

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“…Aside from BPA and its analogs, many other EDCs also relate to the development of IBD, such as phthalates, triclosan, and perfluoroalkyl substances (64-66). For example, exposure to the BPA substitute, fluorene-9-bisphenol, can alter gut metabolites in mice and deregulates the sugar and fatty acid metabolisms in the gut (60). Several epidemiological studies have demonstrated the correlation between other EDCs and IBD (62,66,67).…”

Section: Endocrine Disruptorsmentioning

confidence: 99%

Adverse health effects of emerging contaminants on inflammatory bowel disease

Chen

Wang

Mao

et al. 2023

Front. Public Health

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Inflammatory bowel disease (IBD) is becoming increasingly prevalent with the improvement of people's living standards in recent years, especially in urban areas. The emerging environmental contaminant is a newly-proposed concept in the progress of industrialization and modernization, referring to synthetic chemicals that were not noticed or researched before, which may lead to many chronic diseases, including IBD. The emerging contaminants mainly include microplastics, endocrine-disrupting chemicals, chemical herbicides, heavy metals, and persisting organic pollutants. In this review, we summarize the adverse health effect of these emerging contaminants on humans and their relationships with IBD. Therefore, we can better understand the impact of these new emerging contaminants on IBD, minimize their exposures, and lower the future incidence of IBD.

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“…The incidence areas of CD can occur throughout the gastrointestinal tract, whereas the main incidence area of UC is the colon and rectum [2]. Approximately 3 million adults in the United States were diagnosed with IBD in 2015, and the incidence rate in 2030 is predicted to increase to 4-6 times that [3]. The incidence rate of IBD in China is 3.44%, ranking the highest in Asia [4].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway

Wang

Yang

2022

IJMS

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TLR4/NF-κB is a key inflammatory signaling transduction pathway, closely involved in cell differentiation, proliferation, apoptosis, and pro-inflammatory response. Toll like receptor 4 (TLR4), the first mammalian TLR to be characterized, is the innate immune receptor that plays a key role in inflammatory signal transductions. Nuclear factor kappa B (NF-κB), the TLR4 downstream, is the key to accounting for the expression of multiple genes involved in inflammatory responses, such as pro-inflammatory cytokines. Inflammatory bowel disease (IBD) in humans is a chronic inflammatory disease with high incidence and prevalence worldwide. Targeting the TLR4/NF-κB signaling pathway might be an effective strategy to alleviate intestinal inflammation. Polyphenol phytochemicals have shown noticeable alleviative effects by acting on the TLR4/NF-κB signaling pathway in intestinal inflammation. This review summarizes the pharmacological effects of more than 20 kinds of polyphenols on intestinal inflammation via targeting the TLR4/NF-κB signaling pathway. We expected that polyphenol phytochemicals targeting the TLR4/NF-κB signaling pathway might be an effective approach to treat IBD in future clinical research applications.

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Analyzing the synergistic adverse effects of BPA and its substitute, BHPF, on ulcerative colitis through comparative metabolomics

Cited by 16 publications

References 40 publications

Intracellular hydrogelation of macrophage conjugated probiotics for hitchhiking delivery and combined treatment of colitis

Intracellular hydrogelation of macrophage conjugated probiotics for hitchhiking delivery and combined treatment of colitis

Adverse health effects of emerging contaminants on inflammatory bowel disease

Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway

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