Anaphylactoid Reactions Reported after Treatment with Ciprofloxacin

Hypersensitivity reactions to quinolones

“…Previous attempts to demonstrate the presence of specific IgE to quinolones were without success [18,19]. The first evidence of the presence of specific IgE in vitro was provided by Manfredi et al [20], and later by Aranda et al [7 ], who unequivocally showed the presence of specific IgE to different quinolones using radioimmunoassay (RIA).…”

Detection of specific IgE to quinolones

“…Clinical manifestations include pruritus, urticaria, angioedema, and shock. [6][7][8][9][10][11][12][13][14][15][16][17][18][19] Although certain authors have found skin tests (prick and intradermal) useful for the diagnosis of quinolone allergy, 6,16 others have found that such tests often produce negative results. 19,20 Skin tests have also been shown to have positive results in healthy control subjects.…”

Drug points: Allergy associated with ciprofloxacin

“…Three cases of anaphylactoid reaction occurred—a rate of about 1:1000, much higher than the 1:100 000 quoted (12 cases in a population of 972 000) 3. Two of the three students had no history of atopic illness.…”