Anaphylaxis and the release of active substances in the lungs

Piper, Priscilla J.

doi:10.1016/0306-039x(77)90005-8

Cited by 25 publications

(23 citation statements)

References 148 publications

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“…Some actions of many of these mediators on various bovine blood vessels, including the pulmonary vasculature, have been described previously (Eyre, 1971;Burka & Eyre, 1974a;1977;Holroyde & Eyre, 1975 Aviado, 1962). It appears from the literature, that a bronchial vessel has never previously been studied in vitro, probably because the vessel, being very small, is difficult or impossible to obtain from the usual laboratory animal species.…”

Section: Introductionmentioning

confidence: 77%

“…SRS-A was assayed on guinea-pig ileum in the presence of atropine and mepyramine (1 tg/ml each). One unit of SRS-A was arbitrarily defined as equivalent to 5 ng histamine base contracting the ileum (Burka & Eyre, 1974b;1977 acid (1 pg/ml).…”

Section: Drugsmentioning

confidence: 99%

“…In allergic pulmonary disease, numerous chemical agents (pharmacological mediators) are released from the lung tissue by specific antigen (Austen & Orange, 1976;Piper, 1977;Holroyde, Burka & Eyre, 1977); these mediators are responsible, in part, for the clinical symptoms in obstructive lung disease. Some actions of many of these mediators on various bovine blood vessels, including the pulmonary vasculature, have been described previously (Eyre, 1971;Burka & Eyre, 1974a;1977;Holroyde & Eyre, 1975 Aviado, 1962).…”

Section: Introductionmentioning

confidence: 99%

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Preliminary Pharmacological Characterization of the Bovine Isolated Bronchial Artery Strip: A New Preparation

Arowolo

Eyre

1980

British J Pharmacology

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1This paper describes a preliminary pharmacological study of the isolated helical strip of bovine bronchial artery under isotonic conditions in Krebs-Henseleit solution. 2 The tissue contracted to histamine and 5-hydroxytryptamine (5-HT), actions which were selectively antagonized by mepyramine and methysergide respectively. Histamine was not inhibited by metiamide and 5-HT was not affected by morphine.3 Slow reacting substance of anaphylaxis (SRS-A), prostaglandin F2. (PGF2X) and PGE2 were spasmogenic, whereas PGE1 caused relaxation. No potential antagonists of these agents were tested. 4 Carbachol, at all concentrations, caused contractions of the bronchial artery which were completely, irreversibly blocked by atropine. 5 The spasmogenic action of phenylephrine was selectively blocked by dibenamine. Vessel strips which were partially contracted to histamine, relaxed to isoprenaline and salbutamol. The action of isoprenaline was inhibited similarly by either propranolol or practolol. The evidence therefore suggests the presence of functional a, I, and #2-adrenoceptors.

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Section: Introductionmentioning

confidence: 77%

Section: Drugsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preliminary Pharmacological Characterization of the Bovine Isolated Bronchial Artery Strip: A New Preparation

Arowolo

Eyre

1980

British J Pharmacology

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“…SRS-A has long been known to take part in type I allergic reactions (Piper, 1977;Borgeat, 1981;Lewis & Austen, 1981). Early observations indicated effects on airway smooth muscle contractility both in vivo and in vitro.…”

Section: Resultsmentioning

confidence: 99%

“…The role of the products derived by the cyclooxygenase pathway in the anaphylactic lung reaction is controversial. There are reports of antigen-induced production of prostaglandins and thromboxanes in various species including man and guinea-pig (Piper, 1977;Al Ubaidi & Bakhle, 1980;Spannhake, Hyman & Kadowitz, 1981). However, it has been observed that the cyclo-oxygenase inhibitor indomethacin has no effect on the antigen-induced bronchoconstriction in the guinea-pig (Michoud, Frazer, Pare & Hogg, 1976).…”

Section: Resultsmentioning

confidence: 99%