Anaphylaxis to Chlorpheniramine Maleate and Literature Review

Abstract

Chlorpheniramine maleate is commonly used antihistamine. Since antihistamines are the main therapeutic agents for symptomatic treatment of urticaria, anaphylaxis to antihistamines may lead to errors in diagnosis and treatment. We report a case of anaphylaxis induced by chlorpheniramine maleate confirmed by intradermal test. A 35-year-old female experienced history of anaphylaxis after intramuscular injection of chlorpheniramine maleate. Skin prick test was negative, but intradermal test was positive. Patient also experienced mild dizziness after intradermal test and refused to perform any further evaluation such as oral challenge test. Anaphylaxis for chlorpheniramine maleate is very rare but should be considered.

Effects of Chlorpheniramine Maleate on Catheter-Related Bladder Discomfort in Patients Undergoing Ureteroscopic Stone Removal: A Randomized Double-Blind Study

“…CPM is a first-generation antihistamine and alkylamine that is widely used for symptomatic relief of allergic conditions [10,20]. Its action is achieved by inhibiting H1 receptors on cells, antagonizing the reversible effects of histamine, and competitively inhibiting the target organ [21].…”

“…Its action is achieved by inhibiting H1 receptors on cells, antagonizing the reversible effects of histamine, and competitively inhibiting the target organ [21]. First-generation antihistamines are also competitive inhibitors of muscarinic receptors and have anticholinergic effects [10,11,[21][22][23]]. In addition, antihistamines have an analgesic effect [21,22].…”

“…International Publisher first-generation antihistamine often used to relieve allergic symptoms caused by histamine [10]. First-generation antihistamines are also competitive muscarinic receptor inhibitors and have anticholinergic effects [11].…”

<p>Lichenoid Reaction Caused by Antihistamines and Corticosteroids</p>

“…The case of hypersensitive reactions has been reported since the 1940s. 12 The patient came to consult the general medical practitioner with a complaint of the presence of small papules and itching on the anterior surface of the arm after eating seafood and eggs. The clinical finding suggested that her complaint was caused by food allergy.…”