<p>Lichenoid Reaction Caused by Antihistamines and Corticosteroids</p>

Abstract

Lichenoid reaction (LR) is clinically and histopathologically similar to lichen planus (LP), which involves the skin and mucous membrane. LR has identifiable etiology and can be triggered by systemic drug exposure or any other agents. LR occurs in all racial groups and is predominantly observed in young adults aged 20-40 years, but can occur in any age group. Typically, the clinical manifestation of LR is an itchy rash of small (±3-5 mm) shiny, raised, reddish-purple papules. The rash appears suddenly and commonly affects the anterior surface of the arm and hand and the back part of the body. We report a rare case of LR to antihistamines (cetirizine, loratadine) and corticosteroid (methylprednisolone): an adult female 32-year-old patient, with a chief complaint of burning sensation, a few small rashes and itching on the anterior surface of the arm after eating seafood and eggs 7 days prior to admission. From the detailed and chronologic anamnesis of her dietary habits, routine use of drugs and oral hygiene, and from the histopathological results, we concluded the patient has lichenoid reaction caused by drugs (antihistamines and corticosteroids).

Cutaneous lichenoid drug eruptions: A narrative review evaluating demographics, clinical features and culprit medications

“…Two cases (0.62%) for each of the following drugs were identified: Thioridazine, leflunomide, ibuprofen, sildenafil and ursodeoxycholic acid 124–133 . Single cases of a large number of additional drugs were identified as listed in Table S1 33,77,86,134–169 …”

“…None of the cases reported in the review had severe life‐threatening symptoms. In two cases a bullous lichenoid reaction without mucosal involvement was described, but without fatal outcome or progression to SJS/TEN 7,166 …”

“…In two cases a bullous lichenoid reaction without mucosal involvement was described, but without fatal outcome or progression to SJS/TEN. 7,166 According to the S1 European Guideline of LP, all treatment options are off label, except for topical steroids. Therefore, the treatment of choice are topical steroids, although their efficacy has not been proven in large randomized controlled trials.…”

COVID-19 Pandemic: Oral Health Challenges and Recommendations

“…Remdesivir, an antiviral drug, is still investigational. Chloroquine/hydroxychloroquine is a well-known medication used for the treatment of malaria and certain autoimmune diseases and can result in oral manifestations, particularly allergic lichenoid reaction 62 63 and xerostomia. Combined lopinavir and ritonavir, currently authorized for HIV, can be associated with oral side effects such as xerostomia, stomatitis, and oral ulcers.…”

Oral lichenoid lesion in association with chemotherapy treatment for non-Hodgkin lymphoma or lichen planus? Review of the literature and report of two challenging cases

“…After a literature review, we did not find reports associating the use of R-CVP, Hyper-CVAD, and POMP chemotherapy protocols with the appearance of lichenoid lesions. Nevertheless, there are reports of lichenoid lesions in association with protocols that use one of the components of R-CVP [ 14 , 20 , 21 ] and Hyper-CVAD [ 22 , 23 ], as well as with the use of sulphamethoxazole (prophylactic treatment drugs for infection during chemotherapy) [ 18 ].…”