Anaphylaxis to omeprazole

Hypersensitivity to lansoprazole and rabeprazole with tolerance to other proton pump inhibitors

“…4,7 Two cases of sequential reactions to omeprazole and lansoprazole in the same patient have been described, 2,3 and a case of hypersensitivity to omeprazole showed a prick test positive to lansoprazole, 8 although tests with other PPIs were not performed. We have found only a previous case report of hypersensitivity to lansoprazole and a possible cross-reactivity with rabeprazole, on the evidence of a positive intradermal test, although it was performed from the commercially available formulation.…”

Anaphylaxis to pantoprazole during general anesthesia

“…Anaphylaxis to oral pantoprazole has been reported for 4 patients [7][8][9][10]. In addition, previous reports [11][12][13] described 3 patients who developed anaphylaxis to omeprazole with positive skin prick tests. Lobera and his colleagues [14] demonstrated that there was a cross-reactivity between PPIs in 9 patients who experienced an anaphylactic reaction to oral pantoprazole, omeprazole, and lansoprazole.…”

“…Lobera and his colleagues [14] demonstrated that there was a cross-reactivity between PPIs in 9 patients who experienced an anaphylactic reaction to oral pantoprazole, omeprazole, and lansoprazole. Therefore, until now, only 16 patients have been reported to suffer anaphylaxis to PPIs [7][8][9][10][11][12][13][14], and these reactions did not occur during anesthesia.…”

Hypersensitivity to proton pump inhibitors: Lansoprazole-induced Kounis syndrome

“…Few proton pump inhibitors used in everyday practice have been incriminated in rare occasions to induce hypersensitivity reactions. The older preparations omeprazole [6][7][8][9][10], lansoprazole [11][12][13][14] and pantoprazole [15][16][17] have all been, although rarely, associated with hypersensitivity reactions. A recent literature review [14] has shown that only the newest proton pump inhibitors rabeprazol and esomeprazol are free, so far, of such reactions.…”