Anaphylaxis to sheep's milk cheese in a child unaffected by cow's milk protein allergy

Calvani, Mauro; Alessandri, Claudia

doi:10.1007/s004310050759

Cited by 39 publications

(11 citation statements)

References 10 publications

(12 reference statements)

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“…[97][98][99] Goat's and ewe's milks have also been implicated in anaphylactic reactions. 100,101 Unusual clinical presentations of CMA Unusual clinical presentations are as much a feature of CMA as one might expect from such a ubiquitous allergen source in food and the environment as milk (Box 1). [102][103][104][105][106][107][108][109][110][111][112] The natural history of CMA CMA is primarily of pediatric onset, [113][114][115] is generally outgrown, and is often the first stage of the ''allergic march.''…”

Section: Epidemiology Of Cmamentioning

confidence: 98%

Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA): A summary report

Fiocchi¹,

Schünemann

Brožek

et al. 2010

Journal of Allergy and Clinical Immunology

243

220

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Section: Epidemiology Of Cmamentioning

confidence: 98%

Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA): A summary report

Fiocchi¹,

Schünemann

Brožek

et al. 2010

Journal of Allergy and Clinical Immunology

243

220

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“…In those cases, the IgE binds the caseins (α S1 ‐, α S2 ‐, and β‐caseins) with high specificity and efficiency, but not to the whey proteins, despite their pronounced sequence homology (Ah‐Leung and others ). Several studies report the fact that patients with cow milk allergy have cross‐reactivity with sheep and goat milk, but not the reverse (Wüthrich and Johansson ; Calvani and others ; Umpierrez and others ; Muñoz‐Martín and others ; Viñas and others ). Nonetheless, the reason for this phenomenon is still unclear.…”

Section: Cross‐reactivity Of Milk Allergensmentioning

confidence: 99%

Bovine Milk Allergens: A Comprehensive Review

Villa

Costa

Oliveira

et al. 2017

Comp Rev Food Sci Food Safe

190

145

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Cow milk allergy is one of the most common food allergies in early childhood and often persists through adult life, forcing an individual to a complete elimination diet. Milk proteins are present in uncounted food products, such as cheese, yogurt, or bakery item, exposing allergic persons to a constant threat. Many efforts have been made to overcome this global problem and to improve the life quality of allergic individuals. First, proper and reliable food labeling is fundamental for consumers, but the verification of its compliance is also needed, which should rely on accurate and sensitive analytical methods to detect milk allergens in processed foods. At the same time, strategies to reduce milk allergenicity, such as immunotherapy or the use of food processing techniques to modify allergen structure, have to be extensively studied. Recent research findings on the applicability of food processing, such as heat treatment, fermentation, or high pressure, have revealed great potential in reducing milk allergenicity. In this review, significant research advances on cow milk allergy are explored, focusing on prevalence, diagnosis, and therapy. Molecular characterization of cow milk allergens and cross-reactivity with other nonbovine milk species are described, as well as the effects of processing, food matrix, and digestibility on milk allergenicity. Additionally, analytical methods for the detection of milk allergens in food are described, from immunoassays and mass spectrometry methods for protein analysis to real-time polymerase chain reaction for DNA analysis.

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“…Its use has been reported that it could lead to anaphylactic reaction in children with CMA [18]. Goat milk seems to cross-react not only with cow milk proteins, but also with that of other mammalian milks such as sheep [19–21]. In this aspect, goat milk seems to be as allergic as cow milk [5].…”

Section: Discussionmentioning

confidence: 99%

Camel Milk Is a Safer Choice than Goat Milk for Feeding Children with Cow Milk Allergy

et al. 2011

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Background. Various sources of mammalian milk have been tried in CMA. Objectives. To determine whether camel milk is safer than goat milk in CMA. Methods. Prospective study conducted at Hamad Medical Corporation between April 2007 and April 2010, on children with CMA. Each child had medical examination, CBC, total IgE, cow milk-specific IgE and SPT. CMA children were tested against fresh camel and goat milks. Results. Of 38 children (median age 21.5 months), 21 (55.3%) presented with urticaria, 17 (39.5%) atopic dermatitis, 10 (26.3%) anaphylaxis. WBC was 10, 039 ± 4, 735 cells/μL, eosinophil 1, 143 ± 2, 213 cells/μL, IgE 694 ± 921 IU/mL, cow's milk-specific-IgE 23.5 ± 35.6 KU/L. Only 7 children (18.4%) tested positive to camel milk and 24 (63.2%) to goat milk. 6 (15.8%) were positive to camel, goat, and cow milks. Patients with negative SPT tolerated well camel and goat milks. Conclusions. In CMA, SPT indicates low cross-reactivity between camel milk and cow milk, and camel milk is a safer alternative than goat milk.

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Anaphylaxis to sheep's milk cheese in a child unaffected by cow's milk protein allergy

Abstract: Sheep's milk and cheese derived from sheep's milk may cause severe allergic reactions in children affected and, as we report, in children not affected by cow's milk protein allergy.

Cited by 39 publications

References 10 publications

Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA): A summary report

Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA): A summary report

Bovine Milk Allergens: A Comprehensive Review

Camel Milk Is a Safer Choice than Goat Milk for Feeding Children with Cow Milk Allergy

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