Anaplasma ovis in sheep: Experimental infection, vertical transmission and colostral immunity

Jiménez, C.; Benito, Alfredo A.; Arnal, José Luis; Ortı́n, A.; Gomez, Mónica Lluesma; López, Alicia; Villanueva‐Saz, Sergio; Lacasta, Delia

doi:10.1016/j.smallrumres.2019.07.003

Cited by 15 publications

(35 citation statements)

References 16 publications

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“…It has been reported that the mere presence of the bacteria in the blood is not indicative of disease since once the immune system has defeated the illness, the animals remain carriers for life [ 19 ]. However, an increase in the bacterial load in blood is observed when the clinical signs appear [ 6 ].…”

Section: Resultsmentioning

confidence: 99%

“…Several studies show that the prevalence of A. ovis in the Mediterranean area is significant [ 5 ], although it is barely diagnosed at the field level. In Spain, ovine anaplasmosis was first described in 2014 [ 6 ], causing a severe outbreak in livestock areas in the north of the country. Adult sheep and especially young animals from 1 to 3 years old were affected.…”

Section: Introductionmentioning

confidence: 99%

“…Adult sheep and especially young animals from 1 to 3 years old were affected. The clinical signs were severe anaemia, extreme weakness, anorexia and weight loss [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…During the acute phase, the number of infected erythrocytes doubles every 24–48 h [ 11 ]. The destruction of the erythrocytes and the consequent anaemia are not, however, immediate, beginning to show noticeable changes around 30–40 days after infection [ 6 ]. The haemolytic anaemia associated with this disease is a consequence of the immune response that causes anaplasma in the body.…”

Section: Introductionmentioning

confidence: 99%

“…The main clinical sign of ovine anaplasmosis is anaemia resulting from the destruction of erythrocytes. However, as it is a long-lasting process, signs such as jaundice or haemoglobinuria have not been associated with this disease [ 1 , 6 ]. Likewise, the disease has usually been diagnosed in adult sheep and has not been reported in lambs.…”

Section: Introductionmentioning

confidence: 99%

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Anaplasmosis Outbreak in Lambs: First Report Causing Carcass Condemnation

Lacasta

Ferrer

Sanz

et al. 2020

Animals

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In spring and summer 2020, six outbreaks of condemnation of jaundiced lamb carcasses were diagnosed in different farms in Aragón region, Spain. Anaplasma ovis was identified in all affected farms. Four hundred and ninety-two lambs from two affected farms were more closely examined. Clinical examination, haematologies, biochemistries, histopathology and microbiological and molecular analyses were performed. After slaughter, 34.84% of the lambs showed jaundiced carcasses and 79.64% presented splenomegaly at the abattoir. All tested lambs with icteric carcasses showed positive A. ovis PCR, although 72.72% of the unaffected lambs also tested positive. However, the bacterial load was significantly higher in the animals that showed jaundiced carcasses (Cq: 25.00 vs 26.16; p = 0.004). Moreover, all the tested lambs that showed severe anaemia were PCR positive. On the contrary, the PCR negative lambs did not show anaemia. Lambs that presented icteric carcasses displayed severe regenerative anaemia with significantly lower erythrocyte count (7.18 vs. 11.97), haematocrit (26.89 vs. 34.82) and haemoglobin (8.50 vs. 11.10) than unaffected lambs. Reticulocyte count (18.80 vs. 5.65) was also significantly increased in affected animals. This article describes a new disorder caused by Anaplasma ovis that is producing significant economic losses associated with the carcass condemnation of apparently healthy lamb.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Adult sheep and especially young animals from 1 to 3 years old were affected. The clinical signs were severe anaemia, extreme weakness, anorexia and weight loss [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Anaplasmosis Outbreak in Lambs: First Report Causing Carcass Condemnation

Lacasta

Ferrer

Sanz

et al. 2020

Animals

Self Cite

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Anaplasma ovis infection in sheep from Iran: molecular prevalence, associated risk factors, and spatial clustering

Noaman

Sazmand

2021

Trop Anim Health Prod

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Long-lasting infection with Anaplasma ovis in sheep

Ruiz,

de Arcaute,

Benito

et al. 2023

Vet Res Commun

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Ovine anaplasmosis is an emerging vector-borne disease in Europe caused by Anaplasma ovis. The infection has spread quickly in recent years, causing moderate to severe outbreaks in sheep flocks, leading to relevant economic losses in sheep farming. This wider spread has been associated with global warming and climate change, favouring the maintenance and life cycle of their main vector, the ticks. However, another epidemiological aspect could favour this quick spread. Long persistence infection of Anaplasma ovis has been proposed as a hypothesis in several articles but never scientifically proven. The results of the present study demonstrate that eight adult sheep, both naturally or experimentally infected, maintain Anaplasma ovis load in blood during their whole productive life (4 to 6 years), being permanently infected. In addition, the results suggest that A. ovis bacterial load can be constant or suffer fluctuations, as has been demonstrated in other Anaplasma species. Both aspects can be determinants in the epidemiology and the transmission of the infection.

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Anaplasma ovis in sheep: Experimental infection, vertical transmission and colostral immunity

Cited by 15 publications

References 16 publications

Anaplasmosis Outbreak in Lambs: First Report Causing Carcass Condemnation

Anaplasmosis Outbreak in Lambs: First Report Causing Carcass Condemnation

Anaplasma ovis infection in sheep from Iran: molecular prevalence, associated risk factors, and spatial clustering

Long-lasting infection with Anaplasma ovis in sheep

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