Anaplastic Carcinoma of the Lung and Sarcoidosis

Sarkar, T. K.

doi:10.1111/j.1742-1241.1970.tb03361.x

Int J Clinical Practice

1970

DOI: 10.1111/j.1742-1241.1970.tb03361.x

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Anaplastic Carcinoma of the Lung and Sarcoidosis

T. K. Sarkar¹

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1975

1987

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Solid tumors preceding or following sarcoidosis

Brincker

1987

Med. Pediatr. Oncol.

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Eight cases of sarcoidosis diagnosed after a preceding malignant solid tumor are presented. An analysis of these eight cases along with four previously reported cases was unable to answer the question whether in some cases the development of sarcoidosis may be triggered or modified by a preceding treatment of a malignant tumor. However, in the reverse situation--sarcoidosis preceding cancer--an analysis of 23 such cases from the literature suggests that sarcoidosis preceding cancer appears to be of the chronic active variety and that lung and breast cancer may occur more often than expected after sarcoidosis. Thus, it is conceivable that the immunologic abnormalities associated with sarcoidosis may somehow promote the development of certain malignant tumors. True sarcoidosis may be confused with local sarcoid reactions in cancer patients. One such case is reported in which the finding of a regional sarcoid reaction to a solitary lung metastasis from a uterine adenocarcinoma led to insufficient treatment in the belief that the patient had systemic sarcoidosis.

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Solid tumors preceding or following sarcoidosis

Brincker

1987

Med. Pediatr. Oncol.

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Lung Cancer and Chronic Interstitial Pneumonia Associated With Systemic Sarcoidosis

Kuhara

Wakabayashi

Kishimoto

et al. 1985

Acta Pathologica Japonica

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Lung cancer and chronic interstitial pneumonia associated with systemic sarcoidosis was detected in a 66-year-old woman at autopsy. Histologically, hyalinized sarcoid lesions were scattered in cervical lymph nodes, thoracic lymph nodes, abdominal lymph nodes, and spleen. Scattered non-caseating epithelioid cell granulomas with giant cells were observed in both lungs remoting cancer and chronic interstitial pneumonia. A tumor mass occupying right hilar portion was well-differentiated squamous cell carcimona involving right upper lobe and right hilar lymph nodes. In the lower lobe of the left lung, a small nodule of poorly differentiated squamous cell carcinoma was detected. Alveolar septa, especially in both lower lobes of the lungs were thickened diffusely with fibrosis, edema, and inflammatory cell infiltration. Alveolar cavities contained hyaline membrane and large mononuclear cells. Atypical bronchiolar epithelial proliferation and squamous metaplasia associated with squamous cell carcinoma were detected. The clinical and pathological characteristics among eight reported cases of lung cancer associated with sarcoidosis and three reported cases of interstitial pneumonia associated with sarcoidosis were reviewed separately. There is no report describing both lung cancer and chronic interstitial pneumonia associated with sarcoidosis. ACTA PATHOL.

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Pulmonary Sarcoidosis Presenting as Bronchogenic Carcinoma

Arnett

Hatch

1975

Chest

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Anaplastic Carcinoma of the Lung and Sarcoidosis

Cited by 3 publications

References 2 publications

Solid tumors preceding or following sarcoidosis

Solid tumors preceding or following sarcoidosis

Lung Cancer and Chronic Interstitial Pneumonia Associated With Systemic Sarcoidosis

Pulmonary Sarcoidosis Presenting as Bronchogenic Carcinoma

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