Anaplastic Large-Cell Lymphoma (KM Lymphoma) with Expression of IL-5 mRIMA and Eosinophilic Invasion

Abstract

We examined a patient with anaplastic large-cell lymphoma (Ki-1 lymphoma) showing eosinophilic invasion of the tumor tissues. The number of eosinophils in the peripheral blood changed as a function of the stage of the disease. The IL-5 gene was expressed in the tumor tissues, suggesting that the eosinophilic invasion and eosinophilia were caused by IL-5 derived from the lymphoma cells.

Primary Cutaneous Eosinophil-Rich Anaplastic Large Cell Lymphoma: Report of an Unusual Case and Literature Review

“…IL-5 has been shown to be involved in tissue eosinophilia in other lymphoid diseases, such as HL and Sézary syndrome. 6 In the present case, however, blood eosinophilia was not observed and tissue eosinophilia was less in the second tumor, probably owing to a decrease in IL-5 production by the neoplastic cells. Therefore, this last observation shows that the frequency of the inflammatory pattern of eosinophil-rich C-ALCL may change during the evolution of the disease.…”

“…6 In this case, the blood eosinophilia ceased after chemotherapy. IL-5 has been shown to be involved in tissue eosinophilia in other lymphoid diseases, such as HL and Sézary syndrome.…”

“…6,7 A gastric, eosinophil-rich ALCL with concomitant blood eosinophilia was reported by Takimoto and colleagues in 1996. 6 Two years later, McCluggage and colleagues described three cases of nodal ALCL with a predominant infiltration of eosinophils. 7 To the best of our knowledge, the occurrence of eosinophil-rich C-ALCL has not previously been documented.…”

Primary cutaneous CD30+ anaplastic large cell lymphoma with keratoacanthoma‐like pseudocarcinomatous hyperplasia and marked eosinophilia and neutrophilia

“…The lesions are typically ulcerated with an admixture of neutrophils ranging from 5 to 10% to more than 50% of cells per high‐power field 9 . Studies suggest that the cytokines involved in eosinophilia and neutrophilia are interleukin‐5 (IL‐5) and IL‐8, respectively, and the cytokines are produced by the tumor cells 8,11,12 …”

Adult onset Langerhans cell histiocytosis of the orbit - A case report

“…Occasional cases of malignancies involving cells with the morphologic or immunologic features of Langerhans cells have been reported. 13,14 Immunohistochemistry should be done for a definitive diagnosis. Lesions typical of LCH may accompany, precede or follow malignant lymphoma, leukemias 15 and some solid tumors, including lung cancer and germ cell tumors.…”