Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experience

Hyder, Douglas J.; Sung, Lillian; Pollack, Ian F.; Gilles, Floyd H.; Yates, Allen J.; Davis, Richard L.; Boyett, James M.; Finlay, Jonathan L.

doi:10.1007/s11060-006-9299-6

Cited by 25 publications

(23 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Note that although some clinical studies with children and teenagers surgically treated for oligodendroglial tumors have been published during recent years, they did not report on very long-term prognosis. 1,2,7,[14][15][16][19][20][21] Our clinical results clearly indicate that long-term survival is more common in children and teenagers than in adults with such tumors.…”

mentioning

confidence: 95%

Neurosurgical treatment of oligodendroglial tumors in children and adolescents: a single-institution series of 35 consecutive patients

Lundar

Due-Tønnessen²,

Egge³

et al. 2013

PED

View full text Add to dashboard Cite

Object The object of this study was to delineate long-term results of the surgical treatment of pediatric CNS tumors classified as oligodendroglioma (OD) or oligoastrocytoma (OA) WHO Grade II or III. Methods A cohort of 45 consecutive patients 19 years or younger who had undergone primary resection of CNS tumors originally described as oligodendroglial during the years 1970–2009 at a single institution were reviewed in this retrospective study of surgical morbidity, mortality, and academic achievement and/or work participation. Gross motor function and activities of daily living were scored using the Barthel Index (BI). Results Patient records for 35 consecutive children and adolescents who had undergone resection for an OA (17 patients) or OD (18 patients) were included in this study. Of the 35 patients, 12 were in the 1st decade of life at the first surgery, whereas 23 were in the 2nd decade. The male/female ratio was 1.19 (19/16). No patient was lost to follow-up. The tumor was localized to the supratentorial compartment in 33 patients, the posterior fossa in 1 patient, and the cervical medulla in 1 patient. Twenty-four tumors were considered to be WHO Grade II, and 11 were classified as WHO Grade III. Among these latter lesions were 2 tumors initially classified as WHO Grade II and later reclassified as WHO Grade III following repeat surgery. Fifty-four tumor resections were performed. Two patients underwent repeat tumor resection within 5 days of the initial procedure, after MRI confirmed residual tumor. Another 10 patients underwent a second resection because of clinical deterioration and progressive disease at time points ranging from 1 month to 10 years after the initial operation. Six patients underwent a third resection, and 1 patient underwent a fourth excision following tumor dissemination to the spinal canal. Sixteen (46%) of the 35 children received adjuvant therapy: 7, fractionated radiotherapy; 4, chemotherapy; and 5, both fractionated radiotherapy and chemotherapy. One patient with primary supratentorial disease experienced clinically malignant development with widespread intraspinal dissemination 9 years after initial treatment. Only 2 patients needed treatment for persistent hydrocephalus. In this series there was no surgical mortality, which was defined as death within 30 days of resection. However, 12 patients in the study, with follow-up times from 1 month to 33 years, died. Twenty-three patients, with follow-up times from 4 to 31 years, remained alive. Among these survivors, the BI was 100 (normal) in 22 patients and 80 in 1 patient. Nineteen patients had full- or part-time work or were in normal school programs. Conclusions Pediatric oligodendroglial tumors are mainly localized to the supratentorial compartment and more often occur in the 2nd decade of life rather than the 1st. Two-thirds of the patients remained alive after follow-ups from 4 to 31 years. Twelve children succumbed to their disease, 9 of them within 3 years of resection despite combined treatment with radio- and chemotherapy. Three of them remained alive from 9 to 33 years after primary resection. Among the 23 survivors, a stable, very long-term result was attainable in at least 20. Five-, 10-, 20-, and 30-year overall survival in patients with Grade II tumors was 92%, 92%, 92%, and 88%, respectively.

show abstract

mentioning

confidence: 95%

Neurosurgical treatment of oligodendroglial tumors in children and adolescents: a single-institution series of 35 consecutive patients

Lundar

Due-Tønnessen²,

Egge³

et al. 2013

PED

View full text Add to dashboard Cite

show abstract

“…Astrocytoma, ependymoma and oligodendroglioma tumors usually originate in the cerebrum. Since each tumor responds differently to various treatment strategies, quick and accurate identification is crucial [32,33,34,35,36,37]. In addition, other diagnostic methods, such as immunohistochemical staining, karyotyping, fluorescent in situ hybridization or electron microscopy may be required for a definitive diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Another factor involved with glioma identification is the combination of two different glioma tumors, creating what is known as a mixed glioma [33,36,37]. Although rare, it contains the characteristics of two or more glioma tumors, which naturally affects its diagnosis, treatment and identification.…”

Section: Discussionmentioning

confidence: 99%

Identification of Pediatric Brain Neoplasms Using Raman Spectroscopy

Leslie¹,

Kast

Poulik³

et al. 2012

Pediatr Neurosurg

View full text Add to dashboard Cite

Purpose: Raman spectroscopy can quickly and accurately diagnose tissue in near real-time. This study evaluated the capacity of Raman spectroscopy to diagnose pediatric brain tumors. Experimental Design: Samples of untreated pediatric medulloblastoma (4 samples and 4 patients), glioma (i.e. astrocytoma, oligodendroglioma, ependymoma, ganglioglioma and other gliomas; 27 samples and 19 patients), and normal brain samples (33 samples and 5 patients) were collected fresh from the operating room or from our frozen tumor bank. Samples were divided and tested using routine pathology and Raman spectroscopy. Twelve Raman spectra were collected per sample. Support vector machine analysis was used to classify spectra using the pathology diagnosis as the gold standard. Results: Normal brain (321 spectra), glioma (246 spectra) and medulloblastoma (82 spectra) were identified with 96.9, 96.7 and 93.9% accuracy, respectively, when compared with each other. High-grade ependymomas (41 spectra) were differentiated from low-grade ependymomas (25 spectra) with 100% sensitivity and 96.0% specificity. Normal brain tissue was distinguished from low-grade glioma (118 spectra) with 91.5% sensitivity and 97.8% specificity. For these analyses, the tissue-level classification was determined to be 100% accurate. Conclusion: These results suggest Raman spectroscopy can accurately distinguish pediatric brain neoplasms from normal brain tissue, similar tumor types from each other and high-grade from low-grade tumors.

show abstract

“…El tratamiento estándar inicial en el GAG es multimodal, y la cirugía extensa o resección total gruesa (RTG) es la piedra angular en cualquier edad. En los niños mayores de tres años, se complementará con el manejo adyuvante de radioterapia convencional a dosis no mayores de 60 Gy y/o quimioterapia [8][9][10][11][12] . Hay que valorar la toxicidad tardía como las alteraciones neurocognitivas y neuroendocrinas y las vasculopatías al ofrecer los tratamientos 13 .…”

Section: Introductionunclassified

Factores pronósticos en pacientes con diagnóstico de glioma de alto grado manejados con radioterapia: experiencia en el Hospital Infantil de México Federico Gómez

Chilaca-Rosas

Pérez-Villanueva

Trinidad-Hernández

et al. 2022

GAMO

View full text Add to dashboard Cite

25-31Resumen Introducción: Los gliomas de alto grado (GAG) ocupan el 15-20% de los tumores intracraneales en la población pediátrica y generalmente tienen un pobre pronóstico para la sobrevida global (SG). Objetivo: Obtener los factores pronósticos en términos de SG y control local (CL) en pacientes con diagnóstico de GAG intracraneales manejados con radioterapia conformal. Pacientes y metodología: El presente estudio retrospectivo valoró a todos los pacientes con diagnóstico de GAG tratados con radioterapia en el Hospital Infantil de México Federico Gómez (HIMFG), en el periodo comprendido entre 2008 y 2013, mediante la revisión de expedientes clínicos, expedientes de imagen y planes de tratamiento. Resultados: Los pacientes analizados (n = 18) presentaron una mediana de edad de cinco años. La localización más frecuente fue la infratentorial. Las histologías encontradas fueron: glioblastoma multiforme (GBM) y astrocitoma anaplásico (AA). El 44.4% de los pacientes analizados recibieron manejo quirúrgico por la localización de la lesión y su estado funcional. Todos los pacientes recibieron radioterapia con dosis total > 54 Gy con o sin quimioterapia. El CL fue del 94.4% y la mediana de SG, de 13 meses. En relación con el manejo quirúrgico para la resección tumoral máxima, la resección tumoral subtotal y ninguna resección, la SG a cinco años fue del 100, el 50 y el 36%, respectivamente (p = 0.04). Los pacientes presentaron una mejoría de la SG con la dosis total > 54 Gy y fraccionamiento convencional de radioterapia. Conclusión: En el presente estudio se encontraron los siguientes factores pronósticos en la SG de los pacientes pediátricos con diagnóstico de GAG intracraneales: la resección quirúrgica máxima y el manejo con radioterapia externa convencional con dosis > 54 Gy. (creativecommons.org/licenses/by-nc-nd/4.0/). ARTÍCULO ORIGINALFactores pronósticos en pacientes con diagnóstico de glioma de alto grado manejados con radioterapia: experiencia en el Hospital Infantil de México Federico Gómez

show abstract

Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experience

Abstract: Diagnosis of these tumors is challenging, with only 35% of institutional diagnoses confirmed for AMG and 25% for AO, and survival among children with these tumors is poor, despite intensive therapy. This suggests reliable diagnostic markers and new therapeutic approaches are needed.

Cited by 25 publications

References 25 publications

Neurosurgical treatment of oligodendroglial tumors in children and adolescents: a single-institution series of 35 consecutive patients

Neurosurgical treatment of oligodendroglial tumors in children and adolescents: a single-institution series of 35 consecutive patients

Identification of Pediatric Brain Neoplasms Using Raman Spectroscopy

Factores pronósticos en pacientes con diagnóstico de glioma de alto grado manejados con radioterapia: experiencia en el Hospital Infantil de México Federico Gómez

Contact Info

Product

Resources

About