Anaplastic Transformation of Follicular Thyroid Carcinoma in a Metastatic Skeletal Lesion Presenting with Paraneoplastic Leukocytosis

Nakayama, Robert; Horiuchi, Keisuke; Susa, Michiro; Hosaka, Seiichi; Hayashi, Yuichiro; Kameyama, Kaori; Suzuki, Yoshihisa; Yabe, Hiroo; Toyama, Yoshiaki; Morioka, Hideo

doi:10.1089/thy.2011.0258

Cited by 19 publications

(21 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anaplastic transformation may also take place in a metastatic focus, (Figures 9(a), 9(b), and 9(c)) thus supporting the idea that these lesions originate through the dedifferentiation of preexisting well-differentiated cancer [87–89]. …”

Section: Histogenesissupporting

confidence: 56%

Update on Anaplastic Thyroid Carcinoma: Morphological, Molecular, and Genetic Features of the Most Aggressive Thyroid Cancer

Ragazzi

Ciarrocchi

Sancisi

et al. 2014

International Journal of Endocrinology

151

115

View full text Add to dashboard Cite

Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer. It shows a wide spectrum of morphological presentations and the diagnosis could be challenging due to its high degree of dedifferentiation. Molecular and genetic features of ATC are widely heterogeneous as well and many efforts have been made to find a common profile in order to clarify its cancerogenetic process. A comprehensive review of the current literature is here performed, focusing on histopathological and genetic features.

show abstract

Section: Histogenesissupporting

confidence: 56%

Update on Anaplastic Thyroid Carcinoma: Morphological, Molecular, and Genetic Features of the Most Aggressive Thyroid Cancer

Ragazzi

Ciarrocchi

Sancisi

et al. 2014

International Journal of Endocrinology

151

115

View full text Add to dashboard Cite

show abstract

“…Kaushal et al [10] reported that anaplastic transformation developed in the shoulder 8 years after diagnosis of PTC, and, clinically and pathologically, it mimicked soft tissue sarcoma. Nakayama et al [11] reported anaplastic transformation of follicular carcinoma in pelvic metastasis 12 years after initial diagnosis. The ATCCJ was established to compile data and analyze treatment outcomes of ATC cases from Japan [4].…”

Section: Discussionmentioning

confidence: 99%

“…To date, fewer than 20 cases of anaplastic transformation at the metastatic sites have been reported in the English literature [1,[4][5][6][7][8][9][10][11]. Here, we report an additional case of anaplastic transformation which developed in the pleural metastasis, combined with a literature review.…”

Section: Introductionmentioning

confidence: 95%

Anaplastic Transformation of Papillary Thyroid Carcinoma Only Seen in Pleural Metastasis: A Case Report with Review of the Literature

Kim

Park

et al. 2016

Head and Neck Pathol

View full text Add to dashboard Cite

Anaplastic transformation of papillary thyroid carcinoma (PTC) at distant metastatic sites is extremely rare, and there have been fewer than 20 reported cases in the literature. A 61-year-old woman presented with 1-week history of dyspnea. Her past medical history was remarkable because, 19 years ago, she underwent nearly total thyroidectomy and radical neck dissection due to PTC. Computed tomography of the chest revealed a 1.7 cm nodule in the lung and diffuse pleural thickening. Gun biopsy of the lung nodule revealed metastatic PTC with typical histology. However, the pleural biopsy predominantly showed anaplastic pleomorphic and spindle sarcomatoid carcinoma with microscopic focus of PTC. Immunohistochemical results showed both anaplastic sarcomatoid and PTC components positive for TTF-1, galectin-3 and PAX-8, thus supporting anaplastic transformation of PTC at the metastatic site. Subsequently the patient received 1 cycle of cisplatin-based chemotherapy but died from the disease 4 months after diagnosis. Although it is rare, anaplastic transformation of PTC should be considered during differential diagnosis of patients who present with exclusive sarcomatoid morphology at metastatic sites and have a history of PTC. We report another case of anaplastic transformation of PTC, found at pleural metastasis, together with the immunohistochemical profile and a literature review.

show abstract

“…As in other solid tumours, leukemoid reactions are caused by abnormal production of haematopoietic cytokines from tumour cells including GM-CSF and G-CSF also in thyroid cancer patients 7. Circulating levels of G-CSF and GM-CSF were not measured directly in our patient; however, sensory neuropathy of new onset and its persistence during the development of extreme leucocytosis in a patient whose WBCs had always been in the normal range below 10 000/mm 3 as documented over several years makes it very likely that paraneoplastic release of myelopoietic growth factors was in fact responsible also for his increased pain sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Sensory neuropathy in paraneoplastic leucocytosis

et al. 2012

View full text Add to dashboard Cite

SummaryGranulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) sensitise nerves to mechanical stimuli experimentally and may induce bone and muscle pain when used as supportive drugs. G-CSF and GM-CSF produced endogenously by tumour cells can cause paraneoplastic leucocytosis. Whether paraneoplastic leucocytosis is associated with changes in pain sensitivity is not yet clear. We report on a patient with advanced-stage thyroid cancer who developed extreme leucocytosis within a period of 4 weeks (103 000 white blood cells/mm 3 ), composed mostly of neutrophils and eosinophils. Parallel to this leukemoid reaction, allodynia and hyperalgesia developed in the absence of tissue inflammation. The course of disease of an elderly male with advanced stage metastatic thyroid cancer with new onset neuropathic pain followed by the development of extreme leucocytosis in a leukemoid reaction suggests paraneoplastic release of myeloid CSFs. The coincidence of pain sensitisation and extreme leucocytosis suggests a causal contribution of G-CSF and GM-CSF. BACKGROUND

show abstract

Anaplastic Transformation of Follicular Thyroid Carcinoma in a Metastatic Skeletal Lesion Presenting with Paraneoplastic Leukocytosis

Cited by 19 publications

References 31 publications

Update on Anaplastic Thyroid Carcinoma: Morphological, Molecular, and Genetic Features of the Most Aggressive Thyroid Cancer

Update on Anaplastic Thyroid Carcinoma: Morphological, Molecular, and Genetic Features of the Most Aggressive Thyroid Cancer

Anaplastic Transformation of Papillary Thyroid Carcinoma Only Seen in Pleural Metastasis: A Case Report with Review of the Literature

Sensory neuropathy in paraneoplastic leucocytosis

Contact Info

Product

Resources

About