Anaplastic variant of spermatocytic seminoma

Dundr, Pavel; Pešl, Michael; Povýšil, C; Prokopová, Petra; Pavlík, Ivan; Soukup, Viktor; Dvořáček, J

doi:10.1016/j.prp.2007.04.011

Cited by 20 publications

(22 citation statements)

References 16 publications

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“…It is universally accepted that the sarcomatous differentiation of SS is associated with an aggressive behavior, the presence of metastasis and a poor prognosis (12,13,17,18), despite aggressive surgical and adjuvant treatments (19). On the other hand the anaplastic variant of SS is still poorly known, as in literature only six cases of monolateral tumor have been described so far (6,9,14); this is the first case of bilateral, synchronous anaplastic SS described till today. Still remain ambiguities about its biological behavior and about the most appropriate diagnostic and therapeutic protocol.…”

Section: Discussionmentioning

confidence: 87%

First case of bilateral, synchronous anaplastic variant of spermatocytic seminoma treated with radical orchifunicolectomy as single approach: Case report and review of the literature

Gentile

Giunchi

Schiavina

et al. 2014

Arch Ital Urol Androl

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Spermatocytic Seminoma (SS) is less common than the Classic variant, as its incidence ranges between 1.3% and 2.3% of all seminomas. Generally SS is diagnosed in men older than 50 years. The Anaplastic variant of Spermatocytic Seminoma is characterized by an earlier onset when compared to SS, but a benign behavior in spite of its histological patterns similar to Classic Seminoma. We reported the first case of bilateral, largest and synchronous Anaplastic Spermatocytic Seminoma, in a patient treated with radical orchifunicolectomy alone and with long-term follow-up. The currently available data show that Anaplastic SS reveals a clinically benign behavior, and no distant metastases have been reported so far. A close surveillance after surgery could be considered a valid option in the management of this rare testicular neoplasm.

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Section: Discussionmentioning

confidence: 87%

First case of bilateral, synchronous anaplastic variant of spermatocytic seminoma treated with radical orchifunicolectomy as single approach: Case report and review of the literature

Gentile

Giunchi

Schiavina

et al. 2014

Arch Ital Urol Androl

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“…Other unique pathological features were a multinodular growth pattern with nodules of various sizes separated by fibrous septa; tumor giant cells with high degree of atypia; moderately high mitotic rate with the presence of atypical forms; area of necrosis and vascular invasion; and a Ki-67 index of 30%–40% in areas with anaplastic features 2,16. No more than six cases of the anaplastic variant have been described to date 2,16,17. These patients presented with a painless, rapidly growing mass or testicular enlargement.…”

Section: Discussionmentioning

confidence: 99%

Spermatocytic Variant of Classic Seminoma: A Report of Five Cases and a Brief Review of the Literature

Stein¹,

Charas²,

Drumea³

et al. 2014

Rambam Maimonides Med J

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BackgroundSpermatocytic seminoma is a rare testicular malignancy, appearing in the adult population. It has a good prognosis and a low rate of metastatic potential.ObjectivesWe present five cases diagnosed and treated with radiotherapy at Rambam Health Care Campus in Haifa, Israel.MethodsBetween 1974 and 1996, five patients with stage I spermatocytic seminoma were referred post-orchiectomy to the Northern Israel Oncology Center. All five patients presented with the typical pathological features of the spermatocytic variant of classic seminoma, and all were staged clinically and radiologically.ResultsMean age at diagnosis was 44 years (range 30–58 years). Main symptoms included a palpable testicular mass and/or testicular enlargement. Mean duration of symptoms was 9 months (range 0.5–24 months). Three patients were irradiated to the para-aortic/ipsilateral iliacal lymph nodes (mean total dose 2,500 cGy), one patient with 4,000 cGy. One patient was irradiated to the bilateral iliacal lymph nodes (2,600 cGy). With a median follow-up of 15 years, four patients are alive with no evidence of disease or severe late side effects. One patient developed severe lymphedema and symptomatic peripheral vascular disease, stage IIA prostate carcinoma (hormonal and brachytherapy treatment) and a non-secretory hypophyseal adenoma (surgically removed); he died at the age of 75 due to severe peripheral vascular and coronary heart disease with no evidence of his first or second primaries.ConclusionsPrognosis is excellent and does not differ from classic seminoma. As in the accumulated experience in early-stage, low-risk classic seminoma, we suggest surveillance as the preferred policy.

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“…The nuclei of all the cell types of SS are generally round or slightly oval and with a smooth contour, in contrast with the nuclei of classical seminoma cells, which are generally described as irregularly shaped and “squared-off” [20]. There are many case reviews or case reports that have described unilateral SS associated with rhabdomyosarcomatous or sarcomatous differentiation and anaplastic variant [6,7,20-22,24]. However, bilateral sarcomatous transformation have never been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Depending on the different series, it represents 2 to 12% of all seminomas [5]. Since the first case of SS was described by Masson more than 50 years ago [6], more than 200 cases have been reported, most of them benign [7]. It is a solid tumor found solely in the testis with long duration of symptoms, presentation evident at an early stage, absence of metastasis, and bears an excellent prognosis [8].…”

Section: Introductionmentioning

confidence: 99%

A rare case of bilateral sequential spermatocytic seminoma

Tian

et al. 2013

World J Surg Onc

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Spermatocytic seminoma (SS) is a rare testicular neoplasm characterized by a palpable, painless, slowly enlarging mass in the testis. Even more rare is a synchronous bilateral presentation. Only eight cases of bilateral SS have been reported in the literature, of which three cases were present with synchronous testis enlargement, and five were sequential. Here, we report an additional case of synchronous bilateral SS and present a comprehensive relevant literature review concerning clinical features, histopathology, and treatment.

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Anaplastic variant of spermatocytic seminoma

Cited by 20 publications

References 16 publications

First case of bilateral, synchronous anaplastic variant of spermatocytic seminoma treated with radical orchifunicolectomy as single approach: Case report and review of the literature

First case of bilateral, synchronous anaplastic variant of spermatocytic seminoma treated with radical orchifunicolectomy as single approach: Case report and review of the literature

Spermatocytic Variant of Classic Seminoma: A Report of Five Cases and a Brief Review of the Literature

A rare case of bilateral sequential spermatocytic seminoma

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