Anatomical and mesoscopic characterization of the dystrophic diaphragm: An in vivo nuclear magnetic resonance imaging study in the Golden retriever muscular dystrophy dog

Thibaud, Jean-Laurent; Matot, Béatrice; Barthélémy, I.; Fromes, Y.; Blot, Stéphane; Carlier, Pierre

doi:10.1016/j.nmd.2017.02.003

Cited by 4 publications

(4 citation statements)

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“…Lastly, we measured thickness in the costal region only. Thibaud et al [ 36 ], however, showed by MRI a relative heterogeneity of diaphragm structural alteration in the Golden Retriever model of muscular dystrophy.…”

Section: Discussionmentioning

confidence: 99%

Assessment of diaphragmatic thickness by ultrasonography in Duchenne muscular dystrophy (DMD) patients

et al. 2018

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IntroductionIn Duchenne muscular dystrophy (DMD) the assessment of diaphragmatic function is crucial because respiratory muscle weakness can cause respiratory failure. We aimed to noninvasively assess diaphragmatic function in DMD by measuring diaphragmatic thickness by ultrasonography, under the hypothesis that the progressive decrease of lung function is related to alterations of diaphragmatic thickness.MethodsForty-four DMD patients and thirteen healthy controls were enrolled and subdivided into three age groups. Diaphragmatic thickness was measured during quiet breathing, inspiratory capacity, maximal inspiratory pressure and expiratory pressure maneuvers.ResultsIn DMD, absolute values of diaphragmatic thickness were significantly lower than in controls in the majority of the manoeuvers and diaphragmatic thickness significantly decreased with age at end-expiration, remaining constant at end-inspiration and during maximal inspiratory pressure maneuvers. Comparing to controls, absolute values of diaphragmatic thickness and diaphragmatic thickness variations were significantly lower (p<0.001), with the exception of quiet breathing and maximal expiratory pressure maneuvers in the youngest DMD. During maximal inspiratory pressure maneuver, variation of diaphragmatic thickness was not significantly different in the all groups, nevertheless maximal inspiratory pressure decreases with age.ConclusionsThe diaphragm is prone to pseudo-hypertrophy in the youngest DMD, and to progressive atrophy in middle-age and oldest DMD. Diaphragm impairment could be expressed as a dissociation between muscle drive and muscle developed force. Ultrasonography could be used as a noninvasive method to assess progressive diaphragmatic weakness.

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Section: Discussionmentioning

confidence: 99%

Assessment of diaphragmatic thickness by ultrasonography in Duchenne muscular dystrophy (DMD) patients

et al. 2018

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“…For these publications, the most recent one was included in the analysis. Therefore, the data from 127 original papers 6,8‐11,15,23,27‐29,37‐153 were extracted for further analysis.…”

Section: Resultsmentioning

confidence: 99%

Using MRI to quantify skeletal muscle pathology in Duchenne muscular dystrophy: A systematic mapping review

et al. 2021

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There is a great demand for accurate non-invasive measures to better define the natural history of disease progression or treatment outcome in Duchenne muscular dystrophy (DMD) and to facilitate the inclusion of a large range of participants in DMD clinical trials. This review aims to investigate which MRI sequences and analysis methods have been used and to identify future needs. Medline, Embase, Scopus, Web of Science, Inspec, and Compendex databases were searched up to 2 November 2019, using keywords "magnetic resonance imaging" and "Duchenne muscular dystrophy." The review showed the trend of using T1w and T2w MRI images for semi-qualitative inspection of structural alterations of DMD muscle using a diversity of grading scales, with increasing use of T2map, Dixon, and MR spectroscopy (MRS).High-field (>3T) MRI dominated the studies with animal models. The quantitative MRI techniques have allowed a more precise estimation of local or generalized disease severity. Longitudinal studies assessing the effect of an intervention have also become more prominent, in both clinical and animal model subjects. Quality assessment of the included longitudinal studies was performed using the Newcastle-Ottawa Quality Assessment Scale adapted to comprise bias in selection, comparability, exposure, and outcome. Additional large clinical trials are needed to consolidate research using MRI as a biomarker in DMD and to validate findings against established gold standards. This future work should use a multiparametric and quantitative MRI acquisition protocol, assess the repeatability of measurements, and correlate findings to histologic parameters.

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“…This finding differs from a study done by Thibaud et al they reported no significant difference between the size of the right and left hemidiaphragm in boys with DMD. 23 This could be explained by anatomical difference between both sides which might affect the US technique. 24…”

Section: Discussionmentioning

confidence: 99%

Diaphragmatic and Rectus Femoris Muscles Ultrasonography in Relation to Motor and Respiratory Functions in Ambulatory Boys with Duchenne Muscular Dystrophy

Hassanein,

Elagouza,

Sakr

et al. 2023

Journal of Pediatric Neurology

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Our aim was to establish correlations between GSGC (Gait, Stairs, Gower, Chair) scores and ultrasonographic (US) findings of rectus femoris muscle (RF) and to study correlation between pulmonary function tests (PFT) and diaphragmatic muscles thickness in ambulatory boys with Duchenne muscular dystrophy (DMD). Twenty-four ambulatory boys with DMD were included. Their motor functions were assessed using GSGC scale. All the participants underwent PFT. US was used to assess RF quantitatively (gray scale analysis) and semiquantitatively (modified Heckmatt score) besides assessment of diaphragmatic muscle thickness. Patients with grade IV modified Heckmatt scale had the worst functional performance compared with grade III and II evidenced by having the highest total GSGC score (p < 0.01), worst gait, stairs climbing, chair rising scores, and the longest time for rising from floor (p < 0.05). A significant positive correlation was detected between forced expiratory volume in 1s/ forced vital capacity and right diaphragmatic muscle thickness. GSGC score positively correlated with RF US findings (quantitative gray scale analysis). GSGC score is a successful tool that could be used for clinical evaluation of patients with DMD. Diaphragmatic US introduces an option for screening and monitoring of restrictive respiratory pattern in patients with DMD after determining the reference values of diaphragmatic muscle thickness in different ages.

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Anatomical and mesoscopic characterization of the dystrophic diaphragm: An in vivo nuclear magnetic resonance imaging study in the Golden retriever muscular dystrophy dog

Cited by 4 publications

References 34 publications

Assessment of diaphragmatic thickness by ultrasonography in Duchenne muscular dystrophy (DMD) patients

Assessment of diaphragmatic thickness by ultrasonography in Duchenne muscular dystrophy (DMD) patients

Using MRI to quantify skeletal muscle pathology in Duchenne muscular dystrophy: A systematic mapping review

Diaphragmatic and Rectus Femoris Muscles Ultrasonography in Relation to Motor and Respiratory Functions in Ambulatory Boys with Duchenne Muscular Dystrophy

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