Anatomical and Physiological Substrates of Event‐Related Potentials

Wood, Charles Cresson; McCarthy, Gregory; Squires, Nancy K.; Vaughan, Herbert G.; Woods, David L.; McCallum, W.C.

doi:10.1111/j.1749-6632.1984.tb23595.x

Cited by 183 publications

(38 citation statements)

References 79 publications

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“…In light of recent reports that have located the generator of the P300 in the hippocampal area of the brain (Halgren, Squires, Rohrbaugh, Babb, & Crandall, 1980;Okada, Kaufman, & Williamson, 1983;Wood et al, 1984), it is tempting to speculate that these data support our findings of a relation-…”

Section: Discussionsupporting

confidence: 89%

P300 and Long‐Term Memory: Latency Predicts Recognition Performance

1985

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Tbe study-test paradigm was used to investigate memory acquisition processes and tbe effects of repetition on long-term recognition memory. In tbis procedure, subjects are presented witb a list of words ("targets") to be memorized (Study series). Tbey are later tested for recognition on a word list comprised of tbe target words mixed randomly witb an equal number of new, distractor words (Test series). Botb reaction time and tbe P300 component of tbe event-related brain potential were used as measures of processing time. During tbe Study series, large P300s were elicited despite a word category probability of 1.0. Wben tbe words from tbe Study series were divided on tbe basis of recognition performance, words tbat were subsequently recognized elicited P300s witb sborter latencies tban unrecognized words. P300 amplitude to words in tbe Study series increased witb repetition wbile maintaining a constant latency. During tbe Test series, P300 latency and reaction time decreased witb repetition for botb target and distractor words. P300 amplitude to all words increased substantially over Test repetitions witb tai^et words eliciting larger P300s tban distractor words. Words tbat were recognized more consistently during tbe Test series elicited larger and earlier P300s tban words tbat were recognized less consistently. Tbe P300 amplitude and latency results from botb tbe Study and Test series are interpreted as reflecting tbe increased discriminability of tbe target words as tbe memory trace increases in strengtb.DESCRIPTORS: Event-related potentials, P300, Recognition memory.The P300 component of the event-related brain potential (ERP) has been found to index cognitive processing in a variety of paradigms. There are two parameters of the P300 that provide unique indices of information processing-amplitude and latency. P300 amplitude varies directly with the amount of information processing invoked by a stimulus (i.e., processing load) and varies inversely with the subjective probability of a stimulus (Duncan-Johnson

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Section: Discussionsupporting

confidence: 89%

P300 and Long‐Term Memory: Latency Predicts Recognition Performance

1985

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“…Halgren et al [52] recorded large P300 potentials from electrodes implanted in the hippocampus, parahippocampal gyrus and amygdala of epileptic patients. Okada et al [53] and Wood et al [54] found comparable results from studies using simultaneous scalp recordings. These results indicated a local origin of the P300 in the limbic system.…”

Section: Generators Of P300supporting

confidence: 65%

Neurochemical Substrates and Neuroanatomical Generators of the Event-Related P300

Frodl

Bottlender

Hegerl³

1999

Neuropsychobiology

179

108

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The present review focuses on the current knowledge of the neurochemical processes and neuronal structures involved in the generation of P300. The increasing knowledge in this area facilitates the physiological interpretation of P300 findings as well as the link between P300 research and other research findings in biological psychiatry. Concerning the question of neurochemical substrates, the glutamatergic, GABAergic, cholinergic, noradrenergic, dopaminergic and serotonergic influences on P300 are reviewed. The knowledge of the generating structures of P300 is summarized from intracranial studies, magnetoencephalographic investigations, lesion and animal studies.

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“…This finding may seem surprising in view of reports that electrical activity is generated within medial temporal lobe structures coincident with scalp-recorded P3 waves in humans (Halgren et al, 1980;Okada et al, 1983;Wood et al, 1984).…”

Section: An Animal Model Ofp3contrasting

confidence: 45%

“…The neural generators of P3 waves have been investigated in human subjects using surface and depth electrical recordings as well as magnetic recordings (see review by Wood et al, 1984). Based on such data, several investigators (Halgren et al, 1980(Halgren et al, , 1983Okada, Kaufman, & Williamson, 1983) have proposed that generators contributing to P3 are localized in the medial portion of the temporal lobe (i.e., hippocampus and amygdala).…”

mentioning

confidence: 99%

P3-like brain waves in normal monkeys and in monkeys with medial temporal lesions.

Paller

Zola‐Morgan

Squire

et al. 1988

Behavioral Neuroscience

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The human brain produces a characteristic electrical response to relevant events that occur unexpectedly. Recent reports have suggested that a prominent part of this event-related brain potential-the P3 wave-may be related to memory functions and may arise from activity within the medial temporal lobe, especially the hippocampus. The latter idea was tested by means of epidural recordings of brain waves in monkeys. Responses to deviant auditory stimuli bore a close resemblance to P3 waves recorded from human subjects under comparable conditions. Monkeys with bilateral lesions of the medial temporal lobe still produced P3-like brain waves, which indicates that medial temporal brain structures are not critical for their generation.

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Anatomical and Physiological Substrates of Event‐Related Potentials

Cited by 183 publications

References 79 publications

P300 and Long‐Term Memory: Latency Predicts Recognition Performance

P300 and Long‐Term Memory: Latency Predicts Recognition Performance

Neurochemical Substrates and Neuroanatomical Generators of the Event-Related P300

P3-like brain waves in normal monkeys and in monkeys with medial temporal lesions.

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