Anatomical evidence for direct connections between the shell and core subregions of the rat nucleus accumbens

Dongen, Yvette C. van; Deniau, Jean-Michel; Pennartz, Cyriel M. A.; Graaf, Yvon Galis-de; Voorn, Pieter; Thierry, Anne‐Marie; Groenewegen, Henk J.

doi:10.1016/j.neuroscience.2005.08.050

Cited by 105 publications

(102 citation statements)

References 52 publications

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“…We do not believe that this is likely to be a major confounding factor in our results, given that there is evidence that BDA uptake into fibers of passage is minimal from iontophoretic application sites (Alipour et al, 1997;Power and Mitrofanis, 2002;van Dongen et al, 2005). Nonetheless, it appears that the uptake of BDA by fibers of passage can occur in axons damaged by the pipet or microsyringe used to make the injection (Reiner et al, 2000), which will occur for any injection method.…”

Section: Discussionmentioning

confidence: 84%

Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala

Halberstadt

Balaban

2008

Journal of Chemical Neuroanatomy

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The dorsal raphe nucleus (DRN) contains both serotonergic and non-serotonergic projection neurons. Retrograde tracing studies have demonstrated that components of the basal forebrain and extended amygdala are targeted heavily by input from nonserotonergic DRN neurons. The object of this investigation was to examine the terminal distribution of nonserotonergic DRN projections in the basal forebrain and extended amygdala, using a technique that allows selective anterograde tracing of nonserotonergic DRN projections. To trace nonserotonergic DRN projections, animals were pretreated with nomifensine, desipramine and the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), 7 days prior to placing an iontophoretic injection of biotinylated dextran amine (BDA) into the DRN. In animals treated with 5,7-DHT, numerous nonserotonergic BDA-labeled fibers ascended to the basal forebrain in the medial forebrain bundle system. Some of these labeled fibers crossed through the lateral hypothalamus, bed nucleus of the stria terminalis, and substantial innominata. These fibers entered the amygdala through the ansa peduncularis and ramified within the central and basolateral amygdaloid nuclei. Other fibers entered the diagonal band of Broca and formed a dense plexus of labeled fibers in the dorsal half of the intermediate portion of the lateral septal nucleus and the septohippocampal nucleus. These findings demonstrate that the basal forebrain and extended amygdala receive a dense projection from nonserotonergic DRN neurons. Given that the basal forebrain plays a critical role in processes such as motivation, affect, and behavioral control, these findings support the hypothesis that nonserotonergic DRN projections may exert substantial modulatory control over emotional and motivational functions. Keywords amygdala; bed nucleus; 5,7-dihydroxytryptamine; septal nuclei; biotinylated dextran amine; tyrosine hydroxylase It is well known that the dorsal raphe nucleus contains more than half of all the serotonergic neurons in the brain (Leger and Wiklund, 1982) and is a source of projections that terminate extensively throughout the central nervous system (Vertes, 1991;Sim and Joseph, 1993;Vertes and Kocsis, 1994;Morin and Meyer-Bernstein, 1999 Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. within dorsomedial (DRNdm), ventromedial (DRNvm), and lateral (DRNl) cell groups . It has been proposed that the activity of serotonergic DRN neurons plays an important role in the coordination of sensory processing and motor output with the sleep-wake-arousal cycle (Jacobs and Azmitia, 1992; Forn...

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Section: Discussionmentioning

confidence: 84%

Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala

Halberstadt

Balaban

2008

Journal of Chemical Neuroanatomy

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“…Previous studies suggest that DA transmission within this region is not important for pair bonding (Aragona et al, 2006). However, females were not studied in these previous experiments (Aragona et al 2006), and since the NAc core receives direct input from the NAc shell (van Dongen et al, 2005), it is possible that increased DA transmission in the NAc shell drives core-mediated behavior important for pair bonding in females. Studies using rats have indeed implicated the NAc core in sex differences in other motivated behavior (van Haaren and Meyer, 1991;Li et al, 2004;Wissman et al, 2011).…”

Section: Pair Bond Maintenance Is Mediated By -Opioid Receptors In Thmentioning

confidence: 85%

κ-Opioid Receptors within the Nucleus Accumbens Shell Mediate Pair Bond Maintenance

et al. 2012

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The prairie vole is a socially monogamous species in which breeder pairs typically show strong and selective pair bonds. The establishment of a pair bond is associated with a behavioral transition from general affiliation to aggressive rejection of novel conspecifics. This "selective aggression" is indicative of mate guarding that is necessary to maintain the initial pair bond. In the laboratory, the neurobiology of this behavior is studied using resident-intruder testing. Although it is well established that social behaviors in other species are mediated by endogenous opioid systems, opiate regulation of pair bond maintenance has never been studied. Here, we used resident-intruder testing to determine whether endogenous opioids within brain motivational circuitry mediate selective aggression in prairie voles. We first show that peripheral blockade of -opioid receptors with the antagonist norbinaltorphimine (nor-BNI; 100 mg/kg), but not with the preferential -opioid receptor antagonist naloxone (1, 10, or 30 mg/kg), decreased selective aggression in males. We then provide the first comprehensive characterization of -and -opioid receptors in the prairie vole brain. Finally, we demonstrate that blockade of -opioid receptors (500 ng nor-BNI) within the nucleus accumbens (NAc) shell abolishes selective aggression in both sexes, but blockade of these receptors within the NAc core enhances this behavior specifically in females. Blockade of -opioid receptors within the ventral pallidum or -opioid receptors with the specific -opioid receptor antagonist H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-PenThr-NH2 (1 ng CTAP) within the NAc shell had no effect in either sex. Thus, -opioid receptors within the NAc shell mediate aversive social motivation that is critical for pair bond maintenance.

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“…Pair bonding is an associative process and, although highly interconnected, the NAcc shell and core mediate distinct aspects of associative learning (van Dongen et al, 2005). The NAcc shell is strongly implicated in unconditioned aspects of motivated behavior through processing information related to primary reward (Di Chiara et al, 2004;Wise, 2004).…”

Section: Discussionmentioning

confidence: 99%

Opposing Regulation of Pair Bond Formation by cAMP Signaling within the Nucleus Accumbens Shell

Aragona¹,

Wang²

2007

J. Neurosci.

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The formation of monogamous pair bonds, by prairie voles, is facilitated by activation of dopamine (DA) D 2 -like, but not D 1 -like, receptors within the nucleus accumbens (NAcc) shell. Because DA exerts opposing regulation of cAMP production depending on the subtype of receptor activated, we tested the hypothesis that DA regulation of pair bond formation is mediated via the cAMP signaling cascade. Consistent with activation of D 2 -like receptors, decreasing cAMP signaling, by blocking cAMP binding sites on protein kinase A (PKA), facilitated partner preference formation. Conversely, increasing cAMP signaling, by preventing the activation of inhibitory G-proteins, activating stimulatory G-proteins, or stimulating PKA prevented the formation of mating-induced partner preferences. These manipulations were effective in the shell, but not the core, of the NAcc. Together, these data demonstrate opposing regulation over pair bond formation by cAMP signaling within the NAcc shell.

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Anatomical evidence for direct connections between the shell and core subregions of the rat nucleus accumbens

Cited by 105 publications

References 52 publications

Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala

Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala

κ-Opioid Receptors within the Nucleus Accumbens Shell Mediate Pair Bond Maintenance

Opposing Regulation of Pair Bond Formation by cAMP Signaling within the Nucleus Accumbens Shell

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