Anatomical Reconstruction of Cerebral Vessels as Numerical Grid Models Using Three-dimensional Digital Subtraction Angiography

Hassan, Tamer; Saito, Toshiki; Timofeev, E.; Ezura, Masayuki; Takahashi, Akira; Takayama, Kenji

doi:10.1177/197140090301600564

Cited by 37 publications

(50 citation statements)

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“…While the systemic hemodynamic indices are not direct measures of cerebral vascular disturbance, the fact that they significantly associated with neurocognitive and MRI abnormalities suggests that they have the potential to serve as proxy measures of cerebrovascular health. Wall thickening of the carotid artery (IMT), decreased vascular reactivity on tests of flow-mediated dilation (BAR), and, more generally, vessel stiffening provides evidence of diminished integrity of systemic vascular structure and function, including the possibility of endothelial or vascular smooth muscle dysfunction (Andresen, Shari, & Bryan, 2006;Hassan et al, 2004;Lavi, Gaitini, Milloul, & Jacob, 2006;Panza, Casino, Kilcoyne, & Quyyumi, 1993). Among people with severe CVD, the effects of these systemic abnormalities on the brain would be compounded in the context of diminished or unstable cardiac function.…”

Section: Discussionmentioning

confidence: 99%

Vascular and cognitive functions associated with cardiovascular disease in the elderly

Cohen

Poppas

Forman

et al. 2008

Journal of Clinical and Experimental Neuropsychology

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This study examines the relationship between systemic vascular function, neurocognitive performance, and structural brain abnormalities on magnetic resonance imaging (MRI) among geriatric outpatients with treated, stable cardiovascular disease and no history of neurological illness (n = 88, ages 56-85 years). Vascular function was assessed by cardiac ejection fraction and output, sequential systolic and diastolic blood pressures, flow mediated brachial artery reactivity (BAR), and carotid intima media thickness (IMT). White matter hyperintensities (WMH) on MRI were quantified and examined relative to cognitive and vascular function. Principal component analysis revealed two primary vascular components: one associated with cardiac function, the other with atherosclerotic burden/endothelial dysfunction. Both factors were significantly associated with cognitive function and WMH volume. Reduced systolic variability and increased IMT were most strongly related to reduced attention, executive function, and information-processing speed. These findings suggest the possibility that systemic vascular indices may provide proxy measures of cerebrovascular dysfunction and reinforce the importance of achieving greater understanding of interaction between systemic vascular disease and brain dysfunction among elderly people with cardiovascular disease.Address correspondence to Ronald A. Cohen, Centers for Behavioral and Preventive Medicine, The CORO Building, 5th Floor, One Hoppin Street, Providence, RI 02903, USA (RCohen@lifespan.org). Vascular cognitive impairments (VCI) occur on a continuum ranging from mild deficits among patients with vascular risk factors such as cardiovascular disease (CVD) to the severe cognitive dysfunction characteristic of vascular dementia (Bowler, Steenhuis, & Hachinski, 1999;Rockwood, 2002;Roman, Erkinjuntti, Wallin, Pantoni, & Chui, 2002). Cardiovascular disease was once thought to convey little risk to the brain given its capacity for vascular autoregulation and sustained cerebral perfusion even under adverse hemodynamic conditions (Lassen, 1964). Brain dysfunction secondary to cardiovascular disease was usually attributed to acute stroke during cardiac surgery (Newman et al., 2001), or in response to cardiac events (e.g., arrhythmia). Yet, patients with severe cardiovascular disease frequently exhibit cognitive problems in the absence of clinically identified stroke (Moser et al., 1999;Paul et al., 2005), particularly in cases of heart failure (Bennett & Sauve, 2003;Bornstein, Starling, Myerowitz, & Haas, 1995), presumably reflecting the impact of reduced cardiac function on the aging brain (Roman, 2004). We have previously shown that both cognitive dysfunction and structural brain abnormalities on magnetic resonance imaging (MRI) are associated with reduced cardiac output among patients with severe cardiovascular disease (Jefferson, Poppas, Paul, & Cohen, 2007a;Jefferson et al., 2007b) and abnormalities of systemic vascular function (Gunstad et al., 2006a;Gunstad et al., 2005;Gunstad e...

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Section: Discussionmentioning

confidence: 99%

Vascular and cognitive functions associated with cardiovascular disease in the elderly

Cohen

Poppas

Forman

et al. 2008

Journal of Clinical and Experimental Neuropsychology

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“…Aneurysms presenting a higher surface with low mean WSS were more likely to rupture [33]. Numerical simulations matched to clinical observation allowed to correlate the high fluid-induced WSS with ruptured areas [34].…”

Section: Simulation Without Stentmentioning

confidence: 85%

Methodologies to assess blood flow in cerebral aneurysms: Current state of research and perspectives

Augsburger

Reymond

Fonck

et al. 2009

Journal of Neuroradiology

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KEYWORDSCerebral aneurysms; Blood flow assessment; Particle image velocimetry; Computational fluid dynamics Summary With intracranial aneurysms disease bringing a weakened arterial wall segment to initiate, grow and potentially rupture an aneurysm, current understanding of vessel wall biology perceives the disease to follow the path of a dynamic evolution and increasingly recognizes blood flow as being one of the main stakeholders driving the process. Although currently mostly morphological information is used to decide on whether or not to treat a yet unruptured aneurysm, among other factors, knowledge of blood flow parameters may provide an advanced understanding of the mechanisms leading to further aneurismal growth and potential rupture. Flow patterns, velocities, pressure and their derived quantifications, such as shear and vorticity, are today accessible by direct measurements or can be calculated through computation. This paper reviews and puts into perspective current experimental methodologies and numerical approaches available for such purposes. In our view, the combination of current medical imaging standards, numerical simulation methods and endovascular treatment methods allow for thinking that flow conditions govern more than any other factor fate and treatment in cerebral aneurysms. Approaching aneurysms from this perspective improves understanding, and while requiring a personalized aneurysm management by flow assessment and flow correction, if indicated.

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“…This indicates that AR is a good predictive factor for predisposing rupture (29). Blood flow is turbulent and may lead to cell migration of the muscular middle layer of the vessel wall, which activates the enzyme matrix metalloproteinase (MMPs) and other proteolytic enzymes causing the degeneration and thinning the wall of the aneurysm (10,16,28). AR over 2.0 indicates a predisposition to developing thrombosis because the blood flow in the aneurysm is much slower.…”

Section: Discussionmentioning

confidence: 99%

“…Other important factors for the rupture are the sudden increase of the arterial pressure and the increase of the intracranial volume. The studies of Hassan and Cebral focused in particular on the above mentioned problem (5,6,10). It was discovered that the geometric -morphometric parameters have a great significance in the hemodynamics of the intracranial blood vessels and aneurysms, as well as their rupture.…”

Section: Introductionmentioning

confidence: 99%

Predictible morfometric parameters for ruptrue of intracranial aneurysms – series of 142 operated aneurysms

Nikolić

Tasić²,

Bogosavljevic³

et al. 2011

Turkish Neurosurgery

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AIM: Intracranial aneurysm rupture is followed by high mortality and morbidity. In order to understand the aneurysm's natural course, it is necessary to recognize the predisposing factors for the rupture. ResULTs:The ratio between the width of the aneurysm neck and diameter of the carrying blood vessel -artery in ruptured aneurysms (OR) was 1.58±0.61, and in unruptured aneurysms 1.14±0.52 (p<0.01). Aspect ratio of ruptured aneurysm was 1.89 ± 0.59, and in unruptured 1:33 ± 0.17. The angle of inclination of ruptured aneurysms was 139.22 ± 21.53, while in unruptured aneurysms it was 101.73 ± 21.26. CoNCLUsIoN:Based on the results of our research, a predictive model of morphometric characteristics of the vessel bearing the aneurysm to rupture can be identified: an irregular shape of the aneurysm, AR> 1.6, OR> 1.5 and inclination angle >135 deg. soNUÇ: Araştırmamızın sonuçları temelinde rüptüre olacak anevrizmayı taşıyan damarın morfometrik özelliklerinin prediktif bir modeli tanımlanabilir: Anevrizmada düzensiz şekil, aspekt oranı >1,6, OR >1,5 ve inklinasyon açısı >135 derece.

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Anatomical Reconstruction of Cerebral Vessels as Numerical Grid Models Using Three-dimensional Digital Subtraction Angiography

Cited by 37 publications

References 0 publications

Vascular and cognitive functions associated with cardiovascular disease in the elderly

Vascular and cognitive functions associated with cardiovascular disease in the elderly

Methodologies to assess blood flow in cerebral aneurysms: Current state of research and perspectives

Predictible morfometric parameters for ruptrue of intracranial aneurysms – series of 142 operated aneurysms

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