2018
DOI: 10.1089/jamp.2017.1403
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Anatomically Based Analysis of Radioaerosol Distribution in Pulmonary Scintigraphy: A Feasibility Study in Asthmatics

Abstract: Introduction: Manual analysis of two-dimensional (2D) scintigraphy to evaluate aerosol deposition is usually subjective and has reduced sensitivity to quantify regional differences between central and distal airways. Aims: (1) To present a method to analyze 2D scans based on three-dimensional (3D)-linked anatomically consistent regions of interest (ROIs); (2) to evaluate peripheral-to-central counts ratio (P/C 2D ) and penetration indices (PIs) for a set of 16 subjects with moderate-to-severe asthma; and (3) t… Show more

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Cited by 3 publications
(1 citation statement)
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“…Given the current spatial and temporal limitations of clinical imaging modalities for in vivo human aerosol deposition assessment [10,11] (e.g., gamma scintigraphy), numerical modeling approaches have gained tremendous traction over past decades to characterize aerosol deposition outcomes [12]; such in silico tools have been pivotal in uncovering the mechanistic underpinnings of inhaled aerosol transport and determining local deposition concentrations. Moreover, they have proven useful in evaluating existing inhalers and designing new ones, as well as exploring new inhalation delivery strategies (e.g., controlled particle condensational growth [13,14]).…”
Section: Introductionmentioning
confidence: 99%
“…Given the current spatial and temporal limitations of clinical imaging modalities for in vivo human aerosol deposition assessment [10,11] (e.g., gamma scintigraphy), numerical modeling approaches have gained tremendous traction over past decades to characterize aerosol deposition outcomes [12]; such in silico tools have been pivotal in uncovering the mechanistic underpinnings of inhaled aerosol transport and determining local deposition concentrations. Moreover, they have proven useful in evaluating existing inhalers and designing new ones, as well as exploring new inhalation delivery strategies (e.g., controlled particle condensational growth [13,14]).…”
Section: Introductionmentioning
confidence: 99%