Anatomy and Physiology of the Oral Mucosa

Johnston, Thomas P.

doi:10.1007/978-1-4899-7558-4_1

Cited by 9 publications

(15 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The oral mucosa is a mucous membrane that lines the inside of the mouth. This tissue consists of stratified squamous epithelium (outermost layer), basement membrane, and connective tissue, which is composed of the lamina propria and the submucosa . The buccal, sublingual, gingival, and palatal sites have different barrier properties due to their distinct physical, biophysical, and biochemical characteristics .…”

Section: General Considerations In the Development Of Intraoral Drug mentioning

confidence: 99%

“…Environmental factors such as saliva, mucus, and movement of the oral tissues pose challenges for successful intraoral local drug delivery. The saliva is produced in and secreted from the salivary glands (daily output of saliva in humans is 750–1000 mL) . Saliva consists of water, mucins, inorganic salts, proteins and lipids, exhibiting a pH between 5.8 and 7.6.…”

Section: General Considerations In the Development Of Intraoral Drug mentioning

confidence: 99%

“…Saliva consists of water, mucins, inorganic salts, proteins and lipids, exhibiting a pH between 5.8 and 7.6. The average rate of saliva secretion is 0.2–0.4 mL/min when resting and 2 mL/min when secretion is stimulated . The continuous production of saliva and its outflow into the gastrointestinal tract can lead to drug dilution and clearance from the site, thereby posing a formidable challenge for local drug delivery with liquid and semi‐solid formulations.…”

Section: General Considerations In the Development Of Intraoral Drug mentioning

confidence: 99%

“…The buccal, gingival, and palatal sites are more suitable for extended drug delivery systems. The mouth is coated with a 70‐µm‐thick mucus, which is constantly cleared by swallowing . The movement or friction between the delivery system and oral tissues may dislodge or remove the system/active agent from the applied site .…”

Section: General Considerations In the Development Of Intraoral Drug mentioning

confidence: 99%

“…The anatomy and physiology of the oral cavity directly influences the selection, development, and performance of delivery system intended for intraoral local drug delivery. 98 The oral cavity contains four anatomically distinct sites with unique tissue types, including palatal, gingival, sublingual, and buccal mucosae sites. [99][100][101][102][103][104][105] The oral mucosa is a mucous membrane that lines the inside of the mouth.…”

Section: Anatomical and Physiological Properties Of The Oral Cavitymentioning

confidence: 99%

See 4 more Smart Citations

Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer

Desai

2017

J Biomed Mater Res

View full text Add to dashboard Cite

Oral cancer is among the most prevalent cancers in the world. Moreover, it is one of the major health problems and causes of death in many regions of the world. The traditional treatment modalities include surgical removal, radiation therapy, systemic chemotherapy, or a combination of these methods. In recent decades, there has been significant interest in intraoral site-specific chemoprevention via local drug delivery using polymeric systems. Because of its easy accessibility and clear visibility, the oral mucosa is amenable for local drug delivery. A variety of polymeric systems-such as gels, tablets, films, patches, injectable systems (e.g., millicylindrical implants, microparticles, and in situ-forming depots), and nanosized carriers (e.g., polymeric nanoparticles, nanofibers, polymer-drug conjugates, polymeric micelles, nanoliposomes, nanoemulsions, and polymersomes)-have been developed and evaluated for the local delivery of natural and synthetic chemopreventive agents. The findings of in vitro, ex vivo, and in vivo studies and the positive outcome of clinical trials demonstrate that intraoral site-specific drug delivery is an attractive, highly effective and patient-friendly strategy for the management of oral cancer. Intraoral site-specific drug delivery provides unique therapeutic advantages when compared to systemic chemotherapy. Moreover, intraoral drug delivery systems are self-administrable and can be removed when needed, increasing patient compliance. This article covers important aspects and advances related to the design, development, and efficacy of polymeric systems for intraoral site-specific drug delivery. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1383-1413, 2018.

show abstract

Section: General Considerations In the Development Of Intraoral Drug mentioning

confidence: 99%

Section: General Considerations In the Development Of Intraoral Drug mentioning

confidence: 99%

Section: General Considerations In the Development Of Intraoral Drug mentioning

confidence: 99%

Section: General Considerations In the Development Of Intraoral Drug mentioning

confidence: 99%

Section: Anatomical and Physiological Properties Of The Oral Cavitymentioning

confidence: 99%

See 3 more Smart Citations

Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer

Desai

2017

J Biomed Mater Res

View full text Add to dashboard Cite

show abstract

Controlled Drug Delivery via the Buccal and Sublingual Routes

Morales

Vuddanda

Velaga³

2021

Fundamentals of Drug Delivery

View full text Add to dashboard Cite

Drug delivery techniques for buccal route: formulation strategies and recent advances in dosage form design

Barua

Kim

et al. 2016

Journal of Pharmaceutical Investigation

View full text Add to dashboard Cite

Anatomy and Physiology of the Oral Mucosa

Cited by 9 publications

References 19 publications

Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer

Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer

Controlled Drug Delivery via the Buccal and Sublingual Routes

Drug delivery techniques for buccal route: formulation strategies and recent advances in dosage form design

Contact Info

Product

Resources

About