Anatomy and Physiology of the Peritoneal Membrane

Background/Aims: Continuous ambulatory peritoneal dialysis (CAPD) induces structural changes in the peritoneal membrane such as fibrosis, vasculopathy and angioneogenesis with a reduction in ultrafiltration capacity. Leukotriene (LT) receptor antagonists have been found to be effective to prevent fibrosis in some nonperitoneal tissues. The aim of this study is to investigate the possible beneficial effect of montelukast, a LT receptor antagonist, on peritoneal membrane exposed to hypertonic peritoneal dialysis in uremic rats. Methods: Of the 48 male, 5/6 nephrectomized Wistar rats 29 remained alive and were included in the study. These studied rats were divided into 3 groups: Group I (n=7) was the control group, Group II (n=8) was treated with 20 ml hypertonic PDF intraperitoneally daily and Group III was treated with montelukast and similar PDF treatment protocol. The morphological and functional changes in the peritoneal membrane as well as cytokine expression were compared between groups. Results: Submesothelial thickness and the severity of the degree of hyaline vasculapathy were more prominent in group III when compared to group I. There were no significant differences between group II and other groups in terms of submesothelial thickness and the severity of the degree of hyaline vasculapathy. Increased expressions of TGF-β and VEGF in parietal peritoneal membrane were found in group II and group III when compared to group I. The amount of TGF-β and VEGF expression were similar in group II and group III. Conclusion: This study suggests that montelukast treatment does not prevent the peritoneal membrane from deleterious effects of hyperosmolar PDF in the uremic environment.

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“…The impact of TGF-β on the functional and structural properties of the peritoneal membrane was studied in previous studies [30,31,32]. …”

Section: Discussionmentioning

confidence: 99%

Cysteinyl 1 Receptor Antagonist Montelukast, Does Not Prevent Peritoneal Membrane Damage in Experimental Chronic Peritoneal Dialysis Model in Rats

Yücel

Arıkan

Tuğtepe

et al. 2014

Kidney Blood Press Res

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“…Mesothelial cells are arranged over the basal membrane in the form of a single row and there are connectors and desmosomes at intervals. In addition, there are microvilli on the apical surface of mesothelial cells (1).The mesothelium has a similar structure in all areas of the peritoneum, but there are changes in thickness in the underlying connective tissue and cells. The thinnest mesothelium is in the anterior wall (2).…”

Section: Peritoneal Cavity Morphologymentioning

confidence: 99%

Karbondioksit ile Oluşturulan Pnömoperitoneumun Periton Yapısı Üzerine Etkileri

Saricik¹,

Koca²,

Tarhan³

2017

SDÜ Sağlık Bilimleri Dergisi

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Laparoskopik ameliyatların uygulanmaya başlamasıyla beraber pnömoperiton oluşturmak için birçok gaz denenmiştir. Bunlar arasında halen en yaygın kullanımda olan karbondioksit gazıdır. Karbondioksit ile oluşturulan pnömoperiton laparoskopik ameliyatlarda cerrahlara uygun alan oluşturmasına rağmen peritoneal yapı üzerinde birtakım istenmeyen değişikliklere de sebep olmaktadır. Bu yan etkilerden bazıları kaçınılmaz olmasına rağmen bazı yan etkilerde uygulama şekline bağlı değişiklik gösterebilmektedir. Karbondioksit ile oluşturulan pnömoperitonun peritoneal yapı üzerine etkilerine ilişkin literatürdeki yapılan deneysel ve klinik çalışmalar dikkate alınarak bu derleme hazırlandı. Pnomöperiton oluşumu peritoneal çevreyi ve dolayısıyla organizmayı etkiler. Bu etkilenim intraabdominal basınç artışı, karbondioksitin lokal peritoneal destrüktif etkileri, karbondioksit emilimi ve kimyasal metabolik değişimler gibi sebeplerle olmaktadır. Özellikle ek hastalığı olan ya da obez hastalarda pnömoperitonun yaptığı etkiler hakkında farkındalığa sahip olunması önemlidir. Bu farkındalık hastaların pnömoperitonun yaptığı istenmeyen değişikliklerden etkilenimini azaltacağı kanısındayız

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“…Mesothelial cells possess several different types of intercellular junctions [26][27][28]. Accordingly, we investigated the effect of a high glucose concentration and TGF-b1 on the intercellular junctions of cultured HPMCs [16], and we demonstrated that high glucose induced TGFb1 production by these cells, with both high glucose and TGF-b1 causing damage to the intercellular junctions.…”

Section: Transforming Growth Factor B1mentioning

confidence: 99%

Peritoneal damage by peritoneal dialysis solutions

Ito

Yorioka

2008

Clin Exp Nephrol

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Continuous ambulatory peritoneal dialysis is a well-accepted treatment for end-stage renal disease, but its long-term success is limited. Peritoneal sclerosis is still one of the most important complications of long-term peritoneal dialysis and the low biocompatibility of peritoneal dialysis solutions plays a major role in the development of such sclerosis. In this review, we summarize recent experimental data about the biocompatibility of peritoneal dialysis solutions.

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Anatomy and Physiology of the Peritoneal Membrane

Cited by 14 publications

References 89 publications

Cysteinyl 1 Receptor Antagonist Montelukast, Does Not Prevent Peritoneal Membrane Damage in Experimental Chronic Peritoneal Dialysis Model in Rats

Cysteinyl 1 Receptor Antagonist Montelukast, Does Not Prevent Peritoneal Membrane Damage in Experimental Chronic Peritoneal Dialysis Model in Rats

Karbondioksit ile Oluşturulan Pnömoperitoneumun Periton Yapısı Üzerine Etkileri

Peritoneal damage by peritoneal dialysis solutions

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