Anatomy

Shabetai, Ralph

doi:10.1007/978-1-4419-9137-9_1

Cited by 8 publications

(11 citation statements)

References 41 publications

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“…Lymphatic drainage of the pericardium is then directed mainly to the mediastinal and tracheobronchial lymph nodes and, less frequently, to the prepericardial lymph nodes. [21][22][23] Neoplastic involvement of the pericardium, by direct extension or metastatic spread, can result in tumor dissemination to draining lymph nodes, lymph node enlargement, and obstruction of lymphatic drainage, culminating in pericardial effusions. [24][25][26] Therefore, it is more likely for cytology to sample neoplastic cells suspended in an effusion than it is for a biopsy, especially when there is only focal pericardial involvement by tumor.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic yield of cytopathology in evaluating pericardial effusions: Clinicopathologic analysis of 419 specimens

Saab

Hoda

Narula

et al. 2016

Cancer Cytopathology

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Cytologic examination has significant diagnostic utility in the evaluation of pericardial effusions and exhibits a lower false-negative rate compared with pericardial biopsy. Submission of pericardial biopsy alongside effusion cytology is associated with increased sensitivity for detecting malignancy and may be especially useful in the setting of low-volume pericardial effusion. Cancer Cytopathol 2017;125:128-137. © 2016 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Diagnostic yield of cytopathology in evaluating pericardial effusions: Clinicopathologic analysis of 419 specimens

Saab

Hoda

Narula

et al. 2016

Cancer Cytopathology

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“…The pericardium serves multiple purposes [11] that can be grouped in: (a) membranous, it serves as a barrier against the spread of infection [7] and (b) mechanical, it secures cardiac stability via its attachments within the thorax [12], as will be explained in the following. The mechanical properties of the pericardium itself can be found in [13].…”

Section: Mechanical Physiologymentioning

confidence: 99%

The importance of the pericardium for cardiac biomechanics: from physiology to computational modeling

Pfaller

Hörmann

Weigl

et al. 2018

Biomech Model Mechanobiol

106

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The human heart is enclosed in the pericardial cavity. The pericardium consists of a layered thin sac and is separated from the myocardium by a thin film of fluid. It provides a fixture in space and frictionless sliding of the myocardium. The influence of the pericardium is essential for predictive mechanical simulations of the heart. However, there is no consensus on physiologically correct and computationally tractable pericardial boundary conditions. Here we propose to model the pericardial influence as a parallel spring and dashpot acting in normal direction to the epicardium. Using a four-chamber geometry, we compare a model with pericardial boundary conditions to a model with fixated apex. The influence of pericardial stiffness is demonstrated in a parametric study. Comparing simulation results to measurements from cine magnetic resonance imaging reveals that adding pericardial boundary conditions yields a better approximation with respect to atrioventricular plane displacement, atrial filling, and overall spatial approximation error. We demonstrate that this simple model of pericardial-myocardial inter-M. R. Pfaller * joint last authors action can correctly predict the pumping mechanisms of the heart as previously assessed in clinical studies. Utilizing a pericardial model can not only provide much more realistic cardiac mechanics simulations but also allows new insights into pericardial-myocardial interaction which cannot be assessed in clinical measurements yet.

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“…These increases seemed to be pronounced at longer cycle lengths. The ratio ERP/ DISCUSSION It has previously been suggested that the MAP obtained with suction electrode technique may be taken as a reliable index of the shape of the intracellularly recorded A P during the entire phase of repolarization (29), and that its duration may be regarded as an expression of the refractoriness at the recording site (34, 59). In the present study, decreased cycle lengths caused a linear shortening of the MAPD,, as well as the The major metabolite of procainamide (PA) is N-acetylprocainamide (NAPA).…”

Section: Effect Of Melperonementioning

confidence: 99%

CLASSIFICATION OF CARDIOACTIVE DRUGS IN VIVO BY USING PROGRAMMED ELECTRICAL STIMULATION IN COMBINATION wITH MONOPHASIC ACTION POTENTIAL RECORDINGS AT DIFFERENT PACING RATES

Landmark

Amlie

Refsum

1981

Journal of Internal Medicine

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ABBREVIATIONS MDP = maximal diastolic potential, AP = action potential, Vmax = maximum rate of rise, ERP = effective refractory period, MAP = monophasic action potential, MAPD,, = time for 50% repolarization of MAP. ABSTRACTThe effect of antiarrhythmic drugs on myocardial refractoriness may be due to changes either in V, , , of phase 0 or the phase of repolarization of the AP or both. By using programmed electrical stimulation in combination with MAP recordings at different pacing rates in :he intact dog heart, it was possible to classify and to a certain extent to elucidate the mode of action of various cardioactive drugs in vivo.

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Anatomy

Cited by 8 publications

References 41 publications

Diagnostic yield of cytopathology in evaluating pericardial effusions: Clinicopathologic analysis of 419 specimens

Diagnostic yield of cytopathology in evaluating pericardial effusions: Clinicopathologic analysis of 419 specimens

The importance of the pericardium for cardiac biomechanics: from physiology to computational modeling

CLASSIFICATION OF CARDIOACTIVE DRUGS IN VIVO BY USING PROGRAMMED ELECTRICAL STIMULATION IN COMBINATION wITH MONOPHASIC ACTION POTENTIAL RECORDINGS AT DIFFERENT PACING RATES

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