Anatomy of coronary disease in diabetic patients: an explanation for poorer outcomes after percutaneous coronary intervention and potential target for intervention

Morgan, K.

doi:10.1136/hrt.2003.021014

Cited by 63 publications

(34 citation statements)

References 63 publications

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“…Morgan et al showed that diabetic patients have a higher incidence of multivessel disease, left main stemdisease and complex type C lesion. 4 In this study, the mean levels of lipid variables did allow the discrimination between the presence and absence of multivessel coronary artery disease. In addition, the analysis of severity of coronary artery disease using the score system 8 showed that the variable HDL, TC/HDL and LDL/HDL were also significantly correlated with the atherosclerotic lesion score.…”

Section: Discussionmentioning

confidence: 74%

“…It is scavenged bytissue macrophages creating the foam cell, a constituent ofthe atherosclerotic plaque.So, lipid status is more important in CAD of diabetic patient. 4 This cross-sectional analytical study revealed that dyslipidemia in diabetic patients were associated with higher risk of development of severe coronary atherosclerosis in terms of number of vessel involvement, type of lesions, percentage of obstruction and lesion score.…”

Section: Discussionmentioning

confidence: 86%

“…Tight glycemic control have benefit on microvascular disease but it show no benefit on macrovascular disease, such as coronary artery disease. 4 Increased incidence of hypertension, insulin resistance and adverse lipid profile in diabetic patients predisposes to coronary artery disease. An atherogenic pattern of lipoprotein changes (low HDL, high TG and small size LDL) is often present for years prior to development of fasting hyperglycemia and diagnosis of type 2 diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

“…1 Acute coronary syndrome (ACS) is one of the lifethreatening manifestations of coronary artery disease, includes from unstable angina, acute myocardial infarction (non-ST elevation and ST elevation) and sudden cardiac death. 2 Diabeticpatients presenting with an acute coronary syndrome are morelikely to have a larger culprit lesion, higher incidence of multivessel disease and left main stemdisease (Morgan et al, 2004). Dyslipidemia is an abnormal amount of lipidse.g.…”

Section: Introductionmentioning

confidence: 99%

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Role of Diabetic Dyslipidemia on Coronary Atherosclerotic Severity in Acute Coronary Syndrome

Rabbani¹,

Rahman

Khan

et al. 2017

Bangladesh Heart J

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of Diabetic Dyslipidemia on Coronary Atherosclerotic Severity in Acute Coronary Syndrome

Rabbani¹,

Rahman

Khan

et al. 2017

Bangladesh Heart J

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“…3 Some researchers are showing a diabetic pattern of CAD such as a significant number of stenosis, more spreading stenosis, and a multivessel. 4,5 Factors on DM patient that can increase ACS risk are atherosclerosis acceleration, prothrombic state, and autonomic disfunction. 6 While 20-30% of European patients with NSTE-ACS have known diabetes mellitus, a similar proportion may have undiagnosed diabetes or impaired glucose tolerance.…”

Section: Introductionmentioning

confidence: 99%

ST-Segment Depression as a Predictor of three vessel disease in Non-ST-Segment elevation Acute Coronary Syndromes with Diabetes Mellitus Patients

.¹,

Safri²,

Andra³

et al. 2018

IJPTR

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: Background: Electrocardiogram (ECG) is a simple, non-invasive modality widely used for diagnostic and prognostic tools in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Early identification of three-vessel disease (3-VD) in ECG findings in NSTE-ACS with diabetes mellitus (DM) patients is important, due to consideration of prognosis and revascularization modalities. Previous studies that compare 3-VD incidence based on ST-segment-depression were not specified for NSTE-ACS with DM patients. Especially with our current national insurance system, it can be a guide for healthcare providers in terms of management strategies so that NSTE-ACS with DM patients get optimal management and revascularization. The objective of this study was to assess the predictive value of ST-segment depression for the incidence of 3-VD in NSTE-ACS with DM patients. Methods: 67 NSTE-ACS with DM patients that hospitalized from January 2015-December 2017 in Haji Adam Malik General Hospital were analyzed retrospectively. Patients were divided into two group based on ST-segment depression on admission ECG. Bivariate and multivariate analysis was performed to study the association between ST-segment depression and 3-VD, p-value < 0.05 was considered statistically significant. Results: Bivariate analysis shows that 3-VD incidence was higher in NSTE-ACS with DM patient accompanied by STsegment depression compared to without ST-segment depression (80.6% vs 19.4 %, p <0.001). On multiple logistic regression analysis, patients with ST-segment depression had a 27.3 fold increased the risk for 3-VD compared to patients without ST-segment depression .851), p=0.000]. Conclusion: The presence of ST-segment depression on admission ECG in NSTE-ACS with DM patients was associated with a higher incidence of 3-VD and was the strongest independent predictor of 3-VD. In clinical practice, it may serve as a simple non-invasive tool for predicting 3-VD in NSTE-ACS with DM patients.

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A randomized comparison of sirolimus‐eluting versus bare metal stents in the treatment of diabetic patients with native coronary artery lesions: The DECODE study

Chan

Zambahari

Kaul

et al. 2008

Cathet Cardio Intervent

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Anatomy of coronary disease in diabetic patients: an explanation for poorer outcomes after percutaneous coronary intervention and potential target for intervention

Cited by 63 publications

References 63 publications

Role of Diabetic Dyslipidemia on Coronary Atherosclerotic Severity in Acute Coronary Syndrome

Role of Diabetic Dyslipidemia on Coronary Atherosclerotic Severity in Acute Coronary Syndrome

ST-Segment Depression as a Predictor of three vessel disease in Non-ST-Segment elevation Acute Coronary Syndromes with Diabetes Mellitus Patients

A randomized comparison of sirolimus‐eluting versus bare metal stents in the treatment of diabetic patients with native coronary artery lesions: The DECODE study

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