Anatomy of melancholia: focus on hypothalamic–pituitary–adrenal axis overactivity and the role of vasopressin

Dinan, Timothy G.; Scott, Lucinda V.

doi:10.1111/j.1469-7580.2005.00443.x

Cited by 98 publications

(67 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…70 In similar fashion, patients with major depression show glucocorticoid receptor impairment with decreased glucocorticoid sensitivity, 71 which is compatible with the hypercortisolemia described in depression. 72 It is noteworthy that deficits in the negative feedback of the HPA axis caused by impairment in glucocorticoid receptor function due to depression are resolved after treatment with antidepressants. 73 These findings indicate that disturbances at every level of the HPA axis are relevant for both obesity and depression.…”

Section: A B C D E F G Hmentioning

confidence: 99%

Approaching the shared biology of obesity and depression: the stress axis as the locus of gene–environment interactions

et al. 2006

View full text Add to dashboard Cite

Obesity and depression are serious public health problems and also constitute cardiovascular disease risk factors. Research organizations have called for efforts to explore the interrelationship between obesity and depression. A useful starting point is the fact that in both disorders there is dysregulation of stress systems. We review molecular and clinical evidence indicating that the mediators of the stress response are a key locus for geneenvironment interactions in the shared biology of depression and obesity. Scientific milestones include translational paradigms such as mice knockouts, imaging and pharmacogenomic approaches that can identify new therapeutic strategies for those burdened by these two afflictions of contemporary civilization. Perspectives for the future are promising. Our ability to dissect the underpinnings of common and complex diseases with shared substrates will be greatly enhanced by the Genes and Environment Initiative, the emerging Large Scale Studies of Genes and Environment in Common Disease, and the UK Biobank Project.

show abstract

Section: A B C D E F G Hmentioning

confidence: 99%

Approaching the shared biology of obesity and depression: the stress axis as the locus of gene–environment interactions

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Following the combination of AVP and CRH, a much greater synergistic ACTH response is seen. Monoamine neurotransmitters that play a role in depression pathophysiology also have an important effect on HPA activity (8,10). Moreover, selective serotonin re-uptake inhibitors (SSRIs) have an effect on the regulation of the HPA system (decreased DEX-CRH test response).…”

Section: Vasopressin and Depressionmentioning

confidence: 99%

Sodium and Depression: Hypothetical Associations

Özdemir¹

2013

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

View full text Add to dashboard Cite

“…Although in acute stress responses CRF is the main activator of ACTH secretion, the AVP/V 3 system seems to play a major role during the adaptation to chronic stress conditions (1,19,26). During chronic stress, it has been shown that the hypothalamic content of AVP and V 3 receptor expression in the brain increases (2) and the peptide becomes the main modulator of the HPA axis (1,13,15,19). SSR149415 is a recently characterized, highly selective, centrally acting nonpeptide antagonist of the V 3 receptor.…”

mentioning

confidence: 99%

Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats

Bradesi¹,

Martínez²,

Lao³

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

Bradesi S, Martinez V, Lao L, Larsson H, Mayer EA. Involvement of vasopressin 3 receptors in chronic psychological stressinduced visceral hyperalgesia in rats. Am J Physiol Gastrointest Liver Physiol 296: G302-G309, 2009. First published November 25, 2008 doi:10.1152/ajpgi.90557.2008.-Visceral hypersensitivity and stress have been implicated in the pathophysiology of functional gastrointestinal disorders. We used a selective vasopressin 3 (V 3) receptor antagonist SSR149415 to investigate the involvement of the vasopressin (AVP)/V 3 signaling system in the development of stress-induced visceral hyperalgesia in rats. Rats were exposed to a daily 1-h session of water avoidance stress (WAS) or sham WAS for 10 consecutive days. The visceromotor response to phasic colorectal distension (CRD, 10 -60 mmHg) was assessed before and after stress. Animals were treated daily with SSR149415 (0.3, 1, or 3 mg/kg ip 30 min before each WAS or sham WAS session), with a single dose of SSR149415 (1 mg/kg ip), or the selective corticotropin-releasing factor 1 (CRF 1) antagonist DMP-696 (30 mg/kg po) before CRD at day 11. Effects of a single dose of SSR149415 (10 mg/kg iv) on acute mechanical sensitization during repetitive CRD (12 distensions at 80 mmHg) were also assessed. In vehicle-treated rats, repeated WAS increased the response to CRD, indicating visceral hypersensitivity. Repeated administration of SSR149415 at 1 or 3 mg/kg completely prevented stress-induced visceral hyperalgesia. Similarly, a single dose of DMP-696 or SSR149415 completely blocked hyperalgesic responses during CRD. In contrast, a single dose of SSR149415 did not affect the acute hyperalgesic responses induced by repeated, noxious distension. These data support a major role for V 3 receptors in repeated psychological stress-induced visceral hyperalgesia and suggest that pharmacological manipulation of the AVP/V 3 pathway might represent an attractive alternative to the CRF/CRF 1 pathway for the treatment of chronic stress-related gastrointestinal disorders. corticotropin-releasing factor; DMP-696; functional gastrointestinal disorders; irritable bowel syndrome; SSR149415RECURRENT ABDOMINAL PAIN ASSOCIATED with altered bowel habits and increased perception of physiological and experimental colonic stimuli (visceral hypersensitivity) are characteristic findings in patients with irritable bowel syndrome (IBS) (4). Although the pathophysiological basis of IBS is incompletely understood, epidemiological and experimental data indicate an important role of altered brain-gut interactions in this disorder. For example, many studies have highlighted the importance of certain types of psychological stress in the onset, maintenance, and exacerbation of IBS symptoms (5, 6, 32, 33). Furthermore, higher levels of anxiety, symptom-related anxiety, and comorbidity with anxiety disorders or depression are common in patients with IBS (32,33,49). Recent brain imaging studies have shown greater activation of limbic and paralimbic brain regions (including the amygdala) in patient...

show abstract

Anatomy of melancholia: focus on hypothalamic–pituitary–adrenal axis overactivity and the role of vasopressin

Cited by 98 publications

References 46 publications

Approaching the shared biology of obesity and depression: the stress axis as the locus of gene–environment interactions

Approaching the shared biology of obesity and depression: the stress axis as the locus of gene–environment interactions

Sodium and Depression: Hypothetical Associations

Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats

Contact Info

Product

Resources

About