Approaching the shared biology of obesity and depression: the stress axis as the locus of gene–environment interactions

Bornstein, Stefan R.; Schuppenies, A.; Wong, Ma-Li; Licinio, Júlio

doi:10.1038/sj.mp.4001873

Cited by 237 publications

(184 citation statements)

References 105 publications

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“…Fkbp5 is a strong candidate gene for stress-related metabolic disorders on the basis that it has already been identified as a candidate gene in depression, which shares common overlapping pathways with obesity (Bornstein et al 2006). Importantly, Fkbp5 knockout (51KO) mice are less affected by CSDS and show a reduced body weight compared with WT mice .…”

Section: Discussionmentioning

confidence: 99%

Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51

Balsevich

Uribe

Wagner

et al. 2014

Journal of Endocrinology

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While it is known that stress promotes obesity, the effects of stress within an obesogenic context are not so clear and molecular targets at the interface remain elusive. The FK506-binding protein 51 (FKBP51, gene: Fkbp5) has been identified as a target gene implicated in the development of stress-related psychiatric disorders and is a possible candidate for involvement in stress and metabolic regulation. The aims of the current study are to investigate the interaction between chronic stress and an obesogenic context and to additionally examine whether FKBP51 is involved in this interaction. For this purpose, male C57BL/6 mice were exposed to a high-fat diet for 8 weeks before being challenged with chronic social defeat stress. Herein, we demonstrate that chronic stress induces hypophagia and weight loss, ultimately improving features arising from an obesogenic context, including glucose tolerance and levels of insulin and leptin. We show that Fkbp5 expression is responsive to diet and stress in the hypothalamus and hippocampus respectively. Furthermore, under basal conditions, higher levels of hypothalamic Fkbp5 expression were related to increased body weight gain. Our data indicate that Fkbp5 may represent a novel target in metabolic regulation.

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Section: Discussionmentioning

confidence: 99%

Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51

Balsevich

Uribe

Wagner

et al. 2014

Journal of Endocrinology

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“…Increased food intake and reduced physical activity are characteristic of both conditions (94). Bidirectional causation is also plausible, with suggestions that obesity may be a determinant of later depression in children (97)(98)(99) and conversely hypothesized mechanisms for depression causing obesity (93,95,(98)(99)(100). Indeed, it has more recently been suggested that these two comorbid conditions may mutually reinforce a progressive downward spiral in each other (101) and that additional insight into their longitudinal interaction may be important for intervention strategies (102).…”

Section: Psychosocial Vulnerabilitiesmentioning

confidence: 99%

“…This comorbidity may be due to common genetic and environmental etiologies (93)(94)(95)(96) or common pathways via dysregulation of the hypothalamic-pituitary-adrenal system (93,95,96). Increased food intake and reduced physical activity are characteristic of both conditions (94).…”

Section: Psychosocial Vulnerabilitiesmentioning

confidence: 99%

Biological, environmental, and social influences on childhood obesity

2015

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The prevalence of childhood obesity has increased globally over the past three decades, with evidence of recent leveling off in developed countries. Reduction in the, currently high, prevalence of obesity will require a full understanding of the biological and social pathways to obesity in order to develop appropriately targeted prevention strategies in early life. Determinants of childhood obesity include individual level factors, including biological, social, and behavioral risks, acting within the influence of the child's family environment, which is, in turn, imbedded in the context of the community environment. These influences act across childhood, with suggestions of early critical periods of biological and behavioral plasticity. There is evidence of sex and gender differences in the responses of boys and girls to their environments. The evidence that determinants of childhood obesity act at many levels and at different stages of childhood is of policy relevance to those planning early health promotion and primary prevention programs as it suggests the need to address the individual, the family, the physical environment, the social environment, and social policy. The purpose of this narrative review is to summarize current, and emerging, literature in a multilevel, life course framework. INTRODUCTIONThe prevalence of childhood obesity has increased globally over the past three decades, with more rapid increases recently occurring in low-income countries (1). In the United States, more than 30% of children are now overweight or obese (1), with evidence that the prevalence has leveled off (2). Children and adolescents are exhibiting obesity-related conditions such as type 2 diabetes, elevated blood pressure, low-density lipoprotein cholesterol, and higher fasting insulin levels (3-6). In addition, childhood obesity predicts adulthood obesity and its known health consequences (7,8). Treatment of obesity is notoriously difficult, with weight loss rarely sustained in adults (9). Therapeutic interventions in childhood are somewhat more successful, particularly if the intervention occurs prior to onset of puberty (10). However, real and sustained progress in combating the obesity epidemic will require a full understanding of the biological and social pathways to obesity in order to develop appropriately targeted prevention strategies in early life.Pathways to childhood obesity are complex. It is therefore helpful to discuss determinants of obesity within a conceptual framework. A multilevel conceptual model, Bronfenbrenner's Bioecological Systems Theory (11), has previously been applied to the conceptualization of childhood obesity by Davison and Birch (12). This framework depicts individual-level factors, including biological, social, and behavioral risks, as acting within the influence of the child's family environment, which is, in turn imbedded in the context of the community environment. It is also helpful to consider critical periods for obesity risk and, as will be further illustrated in a later section,...

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“…A global health approach is needed to tackle inequalities in health between the industrialized and developing world. 4,5 A global health strategy has to take into account political, epidemiological, environmental, infrastructural and genetic aspects. The aim is to accomplish the greatest benefit for the most people over the longest period of time and that our significant, but finite, resources are used most effectively.…”

Section: Global Healthmentioning

confidence: 99%

Global meta-analysis of the C-11377G alteration in the ADIPOQ gene indicates the presence of population-specific effects: challenge for global health initiatives

et al. 2008

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Approaching the shared biology of obesity and depression: the stress axis as the locus of gene–environment interactions

Cited by 237 publications

References 105 publications

Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51

Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51

Biological, environmental, and social influences on childhood obesity

Global meta-analysis of the C-11377G alteration in the ADIPOQ gene indicates the presence of population-specific effects: challenge for global health initiatives

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